Dr. Lisheng Wang

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Dr. Lisheng Wang
Associate Professor, Department of Biochemistry, Microbiology and Immunology

Ph.D., University of Sydney (1999)

Roger Guindon Hall, Room 4104 (office), 4105 (lab)

Office: 613-562-5624
Lab: 613-562-5800 ext. 8208
Fax: 613-562-5452

Work E-mail: lwang@uottawa.ca

Dr. Lisheng Wang

Biography

Biographical Sketch

Dr. Lisheng WANG is an Associate Professor in the Department of Biochemistry, Microbiology, and Immunology at University of Ottawa, a Core Member at the Ottawa Institute of Systems Biology, and an Affiliated Investigator at the Ottawa Health Research Institute. He graduated from Medical School in China and received his clinical training as a Fellow in Australian National Liver Transplantation Unit. Dr. Wang completed a PhD at the University of Sydney (Australia) studying the transplantation immunology. He then pursued postdoctoral research in immunology at Harvard Medical School, USA, and further postdoctoral research in stem cell biology and regenerative medicine at Robarts Research Institute, Canada.

Research Interests

Using cellular and molecular approaches and in vivo animal models, Dr. Wang’s laboratory is interested in:

  1. Nurturing human embryonic stem cells (hESCs) into mothers of circulatory cells and immune cells, generating transplantable cells for stem cell-based clinic therapy and reducing transplantation rejection;

  2. Targeting embryonic signaling pathways in cancer for more effective treatment.

hESCs can theoretically divide without limit (termed self-renewal) and grow into almost any type of cell (termed pluripotency), raising attractive prospect of cell replacement therapy to treat or even cure many diseases. Maintenance and differentiation of hESCs are challenging. Using rigorous criteria, Dr. Wang's laboratory has established and improved the techniques to expand, freeze-thaw, maintain, evaluate and differentiate hESCs. Dr. Wang and his colleagues have defined mother cells of endothelium (lining cells in circulatory vessels) and blood during differentiation of hESCs. These mother cells can give rise to either endothelium or blood under different biochemical signals. Further studies have shown that hESC-derived blood cells have repopulating capacity in immunodeficient mice (blood stem cell property). These findings have set up a foundation for future studies.

Note: Dr. Wang is actively recruiting graduate students, postdoctoral fellows and research staff for his lab.

For further information, please contact Dr. Lisheng Wang at 613-562-5624 or lwang@uottawa.ca

Selected Publications

Fields of Interest

  • Embryonic stem cells
  • Regenerative medicine
  • Immune cells
  • Cancer stem cells
  • Microbiology
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