Dr. Manoj M. Lalu MD, PhD, FRCPC

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Dr. Manoj M. Lalu MD, PhD, FRCPC
Lead – Blueprint Translational Research Group, Associate Scientist, Clinical Epidemiology and Regenerative Medicine Programs, OHRI and Assistant Professor of Anesthesiology and Pain Medicine, uOttawa Jr Clinical Research Chair in Innovative Translational Research

Room: Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Civic Campus, 1053 Carling Ave, Room B309, Ottawa, ON, K1Y 4E9

Dr. Manoj M. Lalu

Biography

  Credentials and Qualifications

FRCPC – uOttawa, Canada, 2014
MD - University of Alberta, 2008
PhD Pharmacology - University of Alberta, 2004

 

Appointments

2018 – present - Assistant Professor (Adjunct), Department of Cellular and Molecular Medicine, University of Ottawa

2016 – present - Assistant Professor, Anesthesiology and Pain Medicine, University of Ottawa

2016 - present - Associate Scientist, Clinical Epidemiology Program and Regenerative Medicine Program, Ottawa Hospital Research Institute

 

Academic and Clinical Interests

  • Preclinical to clinical (i.e. “bench-to-bedside”) translation (I co-lead the Blueprint Translational Research Group at the Ottawa Hospital Research Institute)
  • Cell therapy for perioperative medicine and critical illness
  • Reducing risk of bias and improving reporting in preclinical science
  • Preclinical and clinical systematic reviews
  • I am also a member of the Centre for Journalology and have a special interest in Predatory Journals
  • My group integrates patient partners throughout our research (i.e. “patient engagement”)

 

Residents, medical students, and undergraduate students with an interest in the above topics are encouraged to contact me through email (mlalu@toh.ca). I have full graduate student supervisory privileges.

 

Honours and awards

2014 - 2016 - Heart and Stroke Foundation of Canada Research Fellowship
2013 - Canadian Anesthesia Society Resident Research Award
2013 - Physician's Services Incorporated Resident Research Grant

 

Selected Studies

 

Multicenter Preclinical Studies

Mendelson AA, Lansdell C, Fox-Robichaud AE, Liaw P, Arora J, Cailhier JF, Cepinskas G, Charbonney E, Dos Santos C, Dwivedi D, Ellis CG, Fergusson D, Fiest K, Gill SE, Hendrick K, Hunniford VT, Kowalewska PM, Krewulak K, Lehmann C, Macala K, Marshall JC, Mawdsley L, McDonald B, McDonald E, Medeiros SK, Muniz VS, Osuchowski M, Presseau J, Sharma N, Sohrabipour S, Sunohara-Neilson J, Vázquez-Grande G, Veldhuizen RAW, Welsh D, Winston BW, Zarychanski R, Zhang H, Zhou J, Lalu MM; Sepsis Canada’s National Preclinical Sepsis Platform. National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Med Exp. 2021 Mar 19;9(1):14

Zhang M, Macala KF, Fox-Robichaud A, Mendelson AA, Lalu MM; Sepsis Canada National Preclinical Sepsis Platform. Sex- and Gender-Dependent Differences in Clinical and Preclinical Sepsis. Shock. 2021 Jan 4; doi: 10.1097/SHK.0000000000001717

McGinn R, Fergusson DA, Stewart DJ, Kristof AS, Barron CC, Thebaud B, McIntyre L, Stacey D, Liepmann M, Dodelet-Devillers A, Zhang H, Renlund R, Lilley E, Downey GP, Brown EG, Côté L, Dos Santos CC, Fox-Robichaud AE, Hussain SNA, Laffey JG, Liu M, MacNeil J, Orlando H, Qureshi ST, Turner PV, Winston BW, Lalu MM; Canadian Critical Care Translational Biology Group. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians. Crit Care Med. 2021 Feb 1;49(2):311-323.

 

Systematic Reviews (Methodology)

Hunniford VT, Montroy J, Fergusson DA, Avey MT, Wever KE, McCann SK, Foster M, Fox G, Lafreniere M, Ghaly M, Mannell S, Godwinska K, Gentles A, Selim S, MacNeil J, Sikora L, Sena ES, Page MJ, Macleod M, Moher D, Lalu MM. Epidemiology and reporting characteristics of preclinical systematic reviews. PLoS Biol. 2021 May 5;19(5):e3001177. doi: 10.1371/journal.pbio.3001177.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29; 372:n71

 

Perioperative Cardiovascular Complications and Cell Therapy

McIsaac DI, Montroy J, Gagne S, Johnson C, Ernst J, Halman S, Oake J, Chan J, Madden S, Feng S, Moody M, Simard CG, Taljaard M, Foster M, Fergusson DA, Lalu MM. Implementation of the Canadian Cardiovascular Society guidelines for perioperative risk assessment and management: an interrupted time series study. Can J Anaesth. 2021 May 24. English. doi: 10.1007/s12630-021-02026-x

Beattie WS, Lalu MM, Bocock M, Feng S, Wijeysundera DN, Nagele P, Fleisher LA, Kurz A, Biccard B, Leslie K, Howell S, Landoni G, Grocott H, Lamy A, Richards T, Myles P (StEP COMPAC Group) Systematic review and consensus definitions for the Standard Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes. Br J Anaesth. S0007-0912(20)30780-7; 2020

Mazzarello S, McIsaac DI, Beattie WS, Fergusson DA, Lalu MM. Risk Factors for Failure to Rescue in Myocardial Infarction after Noncardiac Surgery: A Cohort Study. Anesthesiology. 133(1):96-108; 2020

Lalu MM, Mazzarello S, Zlepnig J, Dong YY, Montroy J, McIntyre L, Devereaux PJ, Stewart DJ, Mazer CD, Barron C, McIsaac DI, Fergusson DA. Safety and efficacy of adult stem cell therapy for acute myocardial infarction and ischemic heart failure – (SafeCell Heart) a systematic review and meta-analysis. Stem Cells Translational Medicine. 7(12):857-866, 2018.

 

Predatory Journals

Grudniewicz A, Moher D, Cobey KD, Bryson GL, Cukier S, Allen K, Ardem C, Balcom L, Barros T, Berger M, Ciro JB, Cugusi L, Donaldson MR, Egger M, Graham ID, Hodgkinson M, Khan KM, Mabizela M, Manca A, Milzow K, Mouton J, Muchenje M, Olijhoek T, Ommaya A, Patwardhan B, Poff D, Proulx L, Rodger M, Severin A, Strinzel M, Sylos-Labini M, Tamblyn R, van Niekerk M, Wicherts JM, Lalu MM. Predatory journals: no definition, no defense. Nature. 546(7786): 210-212; 2019.

Moher D, Shamseer L, Cobey KD, Lalu MM, Galipeau J, Avey MT, Ahmadzai N, Alabousi M, Barbeau P, Beck A, Daniel R, Frank R, Ghannad M, Hamel C, Hersi M, Hutton B, Isupov I, McGrath TA, McInnes MDF, Page MJ, Pratt M, Pussegoda K, Shea B, Srivastava A, Stevens A, Thavorn K, van Katwyk S, Ward R, Wolfe D, Yazdi F, Yu AM, Ziai H. Stop this waste of people, animals and money. Nature. 549(7670):23-25; 2017

Lalu, MM. Shamseer L, Cobey, KD, Moher, D. How stakeholders can respond to predatory journals. Nature Human Behaviour. 1; 852-855; 2017

 

Patient Engagement

Fox G, Fergusson DA, Daham Z, Youssef M, Foster M, Poole E, Sharif A, Richards DP, Hendrick K, Mendelson AA, Macala KF, Monfaredi Z, Montroy J, Fiest KM, Presseau J, Lalu MM. Patient engagement in preclinical laboratory research: A scoping review. EBioMedicine. 2021 Jul 16;70:103484. doi: 10.1016/j.ebiom.2021.103484.

Foster M, Fergusson DA, Hawrysh T, Presseau J, Kekre N, Schwartz S, Castillo G, Asad S, Fox G, Atkins H, Thavorn K, Montroy J, Holt RA, Mondafaredi Z, Lalu MM. Partnering with patients to get better outcomes with chimeric antigen receptor T-cell therapy: towards engagement of patients in early phase trials. Res Involv Engagem. 6:61; 2020.

Fields of Interest

  • Stem cell therapy for perioperative medicine and critical illness
  • Reducing risk of bias and improving reporting in preclinical science
  • Preclinical and clinical systematic reviews
  • The effect of intermediate care units (step down units) on patient outcomes and resource utilization
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