Dr. Louise Sun MD SM FRCPC FAHA

E-Card

Dr. Louise Sun MD SM FRCPC FAHA
Anesthesiologist and Clinician Scientist, Director of Big Data & Health Bioinformatics Research, UOHI, Associate Professor of Anesthesiology and Epidemiology, Clinical Research Chair in Big Data and Cardiovascular Outcomes, uOttawa, Adjunct Scientist ICES

Room: Department of Anesthesiology and Pain Medicine, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7

Dr. Louise Sun

Biography

Appointments

2020 Associate Professor, Department of Anesthesiology and Pain Medicine, University of Ottawa, Canada, Ontario
2020 Cross Appointment, Associate Professor, School of Epidemiology and Public Health, University of Ottawa, Canada, Ontario
2016 Adjunct Scientist, Cardiovascular Research Program, Institute for Clinical Evaluative Sciences, Canada, Ontario
2016 Cross Appointment, Assistant Professor, School of Epidemiology and Public Health, University of Ottawa, Canada, Ontario
2015 Assistant Professor, Department of Anesthesiology and Pain Medicine, University of Ottawa, Canada, Ontario
2015 Staff, Division of Cardiac Anesthesiology, University of Ottawa Heart Institute

Honours and awards

2020

COVID-19 Leadership Award, University of Ottawa

2020-2024

National New Investigator Award, Heart and Stroke Foundation of Canada (declined due to COVID-19)

2020-2025

Tier 2 Clinical Research Chair in Big Data and Cardiovascular Outcomes, University of Ottawa

2020

Top 10% of reviewers for Anesthesiology (Journal) in 2019

2019

Dr. Robert Roberts Award for Research Excellence, University of Ottawa Heart Institute

2019

Fellow of the American Heart Association (FAHA)

2019

Junior Faculty Excellence Award, University of Ottawa

2019

Designated as one of the top reviewers for the Annals of Internal Medicine in 2018

2018

Vivien Thomas Young Investigator Award Finalist, American Heart Association

2018

Top 3 most-cited papers in Anesthesiology in 2017, “Association of Intraoperative Hypotension with Acute Kidney Injury after Elective Noncardiac Surgery”, Anesthesiology

2017

Top 20 cited articles in Anesthesiology in 2016, “Association of Intraoperative Hypotension with Acute Kidney Injury after Elective Noncardiac Surgery”, Anesthesiology

2016

Designated as one of the top reviewers for the Annals of Internal Medicine in 2015

2013

Finalist, Residents' Competition, Selected as one of the top six resident abstracts at the Canadian Anesthesiologists' Society Meeting, Canadian Anesthesiologists' Society

2012

Second Prize, Residents Competition, Canadian Anesthesiologists' Society

Selected Grants (Lifetime grant support $5.8M)

  1. Principal Investigator Sun L. Co-Investigators Austin PC; Beanlands R Duffett L, Lee DS, Ruel M, Tulloch HE, Wells GA. Development and Application of a Patient-Defined Outcome in Patients with Ischemic Cardiomyopathy. Canadian Institutes of Health Research. $260,101. Jan 2019 to Dec 2021.
  2. Principal Investigator Sun L. Impact of revascularization options on disability-free survival in patients with ischemic cardiomyopathy. Canadian Institutes of Health Research. $260,101. Apr 2019 to Feb 2022.
  3. Principal Investigator Tulloch HE. Co-Investigators Sun L. Psychological Profile and Needs of Patients with Spontaneous Coronary Artery Dissection (SCAD). Heart and Stroke Foundation of Canada. $50,000. Aug 2020 to Jul 2021.
  4. Principal Investigator Lee DS, Wijeysundera H. Co-Investigators Sun L. Population-estimable frailty using "big data” to predict Covid-19 infection and illness severity. Canadian Frailty Network and Canadian Institutes of Health Research. $185,459. Jul 2020 to Feb 2022.
  5. Principal Investigator Birnie DH, Goodman SG, Liu PP. Co-Investigators Chow Chi, Ezekowitz JA, Farkouh ME, Forster AJ, Healey JS, Lawler PR, Lee DS, Mcalister FA, McDonald EG, Oudit GY, Patel RV, Sharma A, So DY, Sun L, Tu K, Wells GA. Improving Outcomes in Individuals with COVID-19 with Renin-Angiotensin System Inhibition: The COVID-RASi Trial. Canadian Institutes of Health Research. $1,176,019. Jul 2020 to Jun 2021.
  6. Principal Investigator Lee DS, Mcalister FA. Co-Investigators Khan NA, Krahn AD, Lindsay MP, Nagpal S, Zieroth SR, Abdel-Qadir HM; Austin PC, Bainey KR, Bakal JA, de Mestral C, Ezekowitz JA, Goodman SG, Greiner R, Ha AC, Jackevicius CA, Kapral MK, Kaul PR, Ko D, Kwong JC, Liu PP, Rochon PA, Roifman I, Ross HJ, Sandhu R, Schull MJ, Sun L, Udell JA, van Diepen S, Wang B, Welsh RC, Wijeysundera HC, Yu AYX. Improving Canadian Outcomes Research On the Novel SARS-CoV-2 using Analytics: the CORONA Consortium. Canadian Institutes of Health Research. $409,179. Jul 2020 to Jun 2021.
  7. Principal Investigator Boet S. Co-Investigators Audette A, Brehaut JC, Burns JK, Cheung W, Etherington N, Grimshaw J, Hamilton S, McCartney C, Posner G, Roth V, Sun L, Taljaard M. Protecting healthcare workers during the COVID-19 pandemic: Improving safe usage of Personal Protective Equipment by video feedback. Ministry of Health and Long-Term Care. $100,000. Jul 2020 to Jun 2021.
  8. Principal Investigator Sun L. Co-Investigators n/a. Protecting healthcare workers during the COVID-19 pandemic: Improving safe usage of Personal Protective Equipment by video feedback. Ministry of Health and Long-Term Care. $25,000. Jul 2020 to Jun 2021.
  9. Principal Investigator Tam DY, Wijeysundera H. Co-Investigators Sun L. Consequences of delays in cardiac procedures and surgeries due to the COVID-19 pandemic. Canadian Cardiovascular Society C3I. $15,000. May 2020 to Apr 2021.
  10. Principal Investigator Tulloch HE. Co-Investigators Sun L. Psychological Profile and Needs of Patients with Spontaneous Coronary Artery Dissection (SCAD). Canadian Institutes of Health Research. $100,000. Apr 2020 to Feb 2021.
  11. Principal Investigator Rubens FD, Sun L. Co-Investigators n/a. Sex differences in outcomes after multiple arterial revascularization. Ministry of Health and Long-Term Care. $50,000. Apr 2019 to Feb 2021.
  12. Principal Investigator Lee DS, Ross HJ. Co-Investigators Sun L. Novel clinical, molecular, & -omics approaches to prediction, stratification & insights on disease mechanism in heart failure. Ted Rogers Innovation Strategic Grant. $1,000,000. Sep 2018 to Aug 2021.
  13. Principal Investigator Boet S. Co-Investigators Sun L. Does one size fit all? The implications of gender for OR team performance, teamwork interventions, and equitable patient outcomes. Canadian Institutes of Health Research. $448,848. Apr 2018 to Feb 2022.
  14. Principal Investigator Tulloch HE, Greenman PS. Co-Investigators Sun L. Healing hearts together. Canadian Institutes of Health Research. $684,675. Apr 2018 to Feb 2022.

Selected Publications

  1. Sun LY, Mielniczuk LM, Liu PP, Beanlands R, Chih S, Davies R, Coutinho T, Lee DS, Austin PC, Bader Eddeen A, Tu JV. (2020). Sex-Specific Temporal Trends in Ambulatory Heart Failure Incidence, Mortality and Hospitalization in Ontario, Canada from 1994-2013 – a Population-Based Cohort Study. BMJ Open. (In-press).

  2. Sun LY, Rodger J, Duffett L, Tulloch H, Crean AM, Chong AY, Rubens FD, MacPhee E, Mesana TG, Lee DS, van Diepen S, Beanlands RS, Ruel M, Julien AM, Bilodeau J. (2020). Derivation of Patient-Defined Adverse Cardiovascular and Noncardiovascular Events through a Modified Delphi Process. JAMA Network Open. (In-press).

  3. Hayatsu Y, Ruel M, Sun LY. (2020). Response to Comment on “Single Versus Multiple Arterial Revascularization in Patients with Reduced Renal Function Long-term Outcome Comparisons in 23,406 CABG Patients from Ontario, Canada”. Annals of Surgery. (In-press).

  4. Sun LY, Gaudino M, Ruel M. (2020). Reply to “Patients with severely reduced ejection fraction undergoing revascularization – is something missing?” JAMA Cardiology. (In-press).

  5. Ruel M, Sun LY, Farkouh M, Gaudino M. (2020). Implications of the ISCHEMIA Trial on the Practice of Surgical Myocardial Revascularization. Journal of Thoracic and Cardiovascular Surgery. S0022-5223(20)32576-9.

  6. Sun LY, Bader Eddeen A, Ruel M, MacPhee E, Mesana TG. (2020). Derivation and Validation of a Clinical Model to Predict Intensive Care Unit Length of Stay after Cardiac Surgery. JAHA. Sep 29:e017847.

  7. Etherington E, Deng M, Boet S, Johnston A, Mansour F, Said H, Zheng K, Sun LY. (2020). The impact of physician sex/gender on processes of care, and clinical outcomes in cardiac operative care: A systematic review. BMJ Open. 10(9):e037139.

  8. Tam DY, Dharma C, Rocha R, Farkouh M, Abdel-Qadir H, Sun L, Wijeysundera H, Austin P, Udell J, Gaudino M, Fremes S, Lee DS. (2020). Improved long-term survival with coronary artery bypass grafting compared to percutaneous coronary intervention in diabetics. J Am Coll Cardiol. 76(10):1153-1164. JIF: 18.6

  9. Sun, LY. (2020). Referee Report For: Validation of EuroSCORE II in patients undergoing coronary artery bypass grafting (CABG) surgery at the National Heart Institute, Kuala Lumpur: a retrospective review. F1000 Research, 7(534). https://doi.org/10.5256/f1000research.22575.r69984

  10. Mamas MA, Brown SA, Sun LY. (2020). Coronary Artery Disease in Cancer patients; It’s always the small pieces that make the bigger picture. Mayo Clinic Proceedings. 95(9):1819-1821.

  11. Mohamed W, Mohamed MO, Hirji S, Ouzounian M, Sun LY, Percy E, Mamas MA. (2020). Trends in Sex-based Differences in Outcomes following Coronary Artery Bypass Grafting in the United States between 2004 and 2015. International Journal of Cardiology. S0167-5273(20)33487-2.

  12. Boet S, Katznelson R, Castellucci L, Booth R, Gonevski M, Soibelman F, Clarke H, Etherington N, Burns J, Gagné S, Djaiani G, Moffett S, Pollock NW, Proulx L, Sun LY, Thavorn K, Wherrett C, Thompson C, Blatteau JE, Louge P, Pignel R, Roth V, MacDonald J, Taljaard M. (2020). Multicentre randomized controlled trial of hyperbaric versus normobaric oxygen therapy for COVID-19 patients. medRxiv. Access at: https://www.medrxiv.org/content/10.1101/2020.07.15.20154609v1. doi: https://doi.org/10.1101/2020.07.15.20154609

  13. Ristovic V, de Roock S, Mesana TG, van Diepen S, Sun LY. (2020). The Impact of Preoperative Risk on the Association Between Hypotension and Mortality After Cardiac Surgery. Journal of Clinical Medicine. 30;9(7):E2057

  14. Sun LY, Gaudino M, Chen RJ, Bader Eddeen A, Ruel M. (2020). Long-Term Outcomes of Patients with Severely Reduced Left Ventricular Ejection Fraction Undergoing Percutaneous Coronary Intervention versus Coronary Artery Bypass Grafting. JAMA Cardiology. Online first Apr 8:e200239. JIF: 11.9

  15. Ngu J, Jabagi H, Chung A, Boodhwani M, Ruel M, Bourke M, Sun LY. (2020). Defining an intraoperative hypotension threshold in association with de novo renal replacement therapy after cardiac surgery. Anesthesiology. 132(6):1447-1457. JIF: 6.5

  16. Sun LY, Spence S, Benton S, Beanlands R, Bader Eddeen A, Lee DS. (2020). Age, Not Sex, Modifies the Effect of Frailty on Long-term Outcomes after Cardiac Surgery. Annals of Surgery. Online first June 24. JIF: 9.5

  17. Hayatsu Y, Ruel M, Bader Eddeen A, Sun LY. (2020). Single versus Multiple Arterial Revascularization in Patients with Reduced Renal Function: Long-Term Outcome Comparisons in 23,406 CABG Patients from Ontario, Canada. Annals of Surgery. Online first June 11. JIF: 9.5

  18. Rubens FD, Coutinho T, Bader Eddeen A, Sun LY. (2020) The impact of a second arterial conduit on longterm post-discharge outcomes in women and men after coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery. S0022-5223(20)31007-2. JIF: 5.2

  19. Zelt JGE, Hossain A, Sun LY, Mehta S, Chandy G, Davies RA, Contreras-Dominguez V, Dunneb R, Doyle-Cox C, Wells G, Stewart DJ, Mielniczuk LM. (2020). Incorporation of Renal Function in Mortality Risk Assessment for Pulmonary Arterial Hypertension. Journal of Heart and Lung Transplantation. S1053-2498(20):31487 JIF: 8.0

  20. Hayatsu Y, Dryden A, Messika-Zeitoun D, Sun LY, Mesana T, Ruel M. (2020). Direct implant of a transcatheter aortic valve prosthesis for prosthetic mitral valve endocarditis. Canadian Journal of Cardiology Open. 13;2(4):303-305.

  21. Hoang-Kim A, Parpia C, Freitas C, Austin PC, Ross HJ, Wijeysundera H, Tu K, Mak S, Farkouh ME, Sun L, Schull MJ, Mason R, Lee DS, Rochon PA. (2020). Readmission Rates Following Heart Failure: A Scoping Review of Sex and Gender Based Considerations. BMC Cardiovascular Disorders. 20(1):223. JIF: 1.9

  22. Monaco F, Di Prima AL, Kim JH, Plamondon MJ, Yavorovskiy A, Likhvantsex V, Lomivorotov V, Hajjar LA, Landoni G, Riha H, Farag AMGA, Gazivoda G, Lei C, Bradic N, El-Tahan MR, Bukamal NAR, Sun LY, Wang CY. (2020). Management of Challenging Cardiopulmonary Bypass Separation. J Cardiothorac Vasc Anesth.

  23. Sun LY. (2020). Preoperative risk, blood pressure, and acute kidney injury. Anesthesiology. 132(3):416-417. JIF: 6.5

  24. Sun LY, Ruel M. (2019). Hypotension and Stroke in Cardiac Surgery. Anesthesiology. 131(1):217-218. JIF: 6.5

  25. Kandolin RM, Wiefels CC, Mesquita CT, Chong AY, Boland P, Glineur D, Sun L, Beanlands RS, Mielniczuk LM. (2019). The current role of viability imaging to guide revascularization and therapy decisions in patients with heart failure and reduced LV function. Canadian Journal of Cardiology. 35(8): 1015-1029. JIF: 5.6

  26. Jabagi H, Ruel M, Sun LY. (2019). Can Biomarkers Provide Right Ventricular-Specific Prognostication after Cardiac Surgery? Journal of Cardiac Failure. S1071-9164(19): 30516. JIF: 3.9

  27. Hayatsu Y, Ruel M, Sun LY. (2019) Renal Insufficiency and Severe Coronary Artery Disease: Should CABG, OPCAB or PCI be performed? Current Opinion in Cardiology. 34(6):645–649. JIF: 2.0

  28. Johnston A, Mesana TG, Lee DS, Bader Eddeen A, Sun LY. (2019) Sex Differences in Long-Term Survival After Major Cardiac Surgery: A Population-Based Cohort Study. JAHA, 8(17):e013260. JIF: 4.7

  29. Sun LY, Kimmoun A, Takagi K, Liu PP, Bader Eddeen A, Mebazaa A. (2019). Ethnic Differences in Acute Heart Failure Outcomes in Ontario. International Journal of Cardiology, 291:177-182.25. JIF: 4.0

  30. Jagabi H, Mielniczuk LM, Liu PP, Ruel M, Sun LY. (2019). Role of Biomarkers in the Diagnosis, Management, and Prognostication of Perioperative Right Ventricular Failure after Cardiac Surgery. J Clin Med, 8(4), 559. JIF: 5.7

  31. Jabagi H, Boodhwani M, Tran DT, Sun L, Wells G, Rubens FD. The Effect of Preoperative Anemia on Patients Undergoing Cardiac Surgery: A Propensity-Matched Analysis. Semin Thorac Cardiovasc Surg. 2019;31(2):157-163.

  32. Ruel M, Sun LY, Gaudino MF. (2019). Navigating the SYNTAX Score according to Diabetic Status: What does this mean for the patient requiring myocardial revascularization? Journal of Thoracic and Cardiovascular Surgery, pii: S0022-5223(19)31025-6. JIF: 5.2

  33. Ruel M, Sun LY. (2019). Postoperative Use of Calcium-Channels Blockers in Patients with a Radial Artery Graft: Do We Now Have a Definitive Answer? J Am Coll Cardiol, 14;73(18):2307-2309. JIF: 18.6

  34. Verma S, Southern DA, Raslan I, Norris CM, Graham MM, Bagshaw SM, Nagendran J, MacClure T, Sun LY, Chin WD, van Diepen S. (2019). Prospective validation and refinement of the APPROACH cardiovascular surgical intensive care unit readmission score. Journal of Critical Care. 54:117-121. JIF: 2.2

  35. Ngu JMC, Ruel M, Sun LY. (2018). Left Ventricular Function Recovery After Revascularization: Comparative Effects of PCI and CABG. Current Opinion in Cardiology, 33(6), 633-637. JIF: 2.0

  36. Hui SK, Sun LY, Ruel M. (2018). Genetics, coronary artery disease, and myocardial revascularization: will novel genetic risk scores bring new answers?. Indian Journal of Thoracic and Cardiovascular Surgery, 34(3), 213-221.

  37. Zelt JGE, Mielniczuk LM, Liu PP, Dupuis JY, Chih S, Akbari A, Sun LY. (2018). Utility of Novel Cardiorenal Biomarkers in the Prediction and Early Detection of Congestive Kidney Injury Following Cardiac Surgery. J. Clin. Med, 7(12), 540. JIF: 5.7

  38. Sun LY, Tu JV, Bader Eddeen A, Liu PP. (2018). Long-Term Survival After Coronary Artery Bypass Grafting in Men and Women with Heart Failure and Preserved vs Reduced Ejection Fraction. Journal of the American Heart Association, 7(12), pii: e008902. JIF: 4.7

  39. Ngu JMC, Sun LY, Ruel M. (2018). Pivotal contemporary trials of PCI vs CABG: A surgical perspective. Annals of Cardiothoracic Surgery, 7(4), 527-532.

  40. Hui SK, Lindale E, Sun L, Ruel M. (2018). Genetics of coronary artery disease: should they impact the choice of revascularization?. Current Opinion in Cardiology, 33(6), 605-612. JIF: 2.0

  41. Tran DTT, Tu JV, Dupuis JY, Bader Eddeen A, Sun LY. (2018). Association of Frailty and Long-Term Survival in Patients Undergoing Coronary Artery Bypass Grafting. JAHA, 7(15), pii: e009882. JIF: 4.7

  42. Sun LY, Tu JV, Coutinho T, Turek M, Rubens F, McDonnell L, Tulloch H, Mielniczuk LM. (2018). Sex Differences in Heart Failure Outcomes in an Ambulatory, Population-Based Cohort. CMAJ, 190(28), E848-E854. JIF: 6.9

  43. Sun LY, Tu JV, Sherrard H, Coutinho T, Turek M, Rodger N, McDonnell L, Tulloch H, Mielniczuk LM. (2018). Sex-Specific Temporal Trends in Incidence and Mortality for Urban and Rural Ambulatory Heart Failure Patients in Eastern Ontario. Journal of Cardiac Failure, pii: S1071-9164(18), 30870-4. JIF: 3.9

  44. Ngu JMC, Sun LY. (2018). Referee Report For: Significance of intra-operative blood pressure data resolution: A retrospective, observational study. F1000 Research, 7(251).

  45. Sun LY, Chung AM, Farkouh M, Van Diepen S, Weinberger J, Bourke M, Ruel M. (2018). Defining a Peri-operative Hypotension Threshold in Association with Stroke in Cardiac Surgery. Anesthesiology, 129(3), 440-447. JIF: 6.5

  46. Jagabi H, Boodhwani M, Tran DT, Sun LY, Well G, Rubens FD. (2018). The effect of preoperative anemia on patients undergoing cardiac surgery: a propensity-matched analysis. Seminars in Thoracic and Cardiovascular Surgery, S1043-0679(18), 30215-6.

  47. Sun LY, Tu JV, Lee DS, Beanlands RS, Ruel M, Austin PC, Bader Eddeen A, Liu PP. (2018). Disability-Free Survival After Coronary Artery Bypass Grafting in Women and Men with Heart Failure and Preserved versus Reduced Ejection Fraction. Open Heart, 5, e000911.

  48. Prince SA, McDonnell LM, Turek M, Visintini S, Nahwegahbow AJ, Kandasamy S, Sun LY, Coutinho T. (2017). The State of Affairs of Cardiovascular Health Research in Indigenous Women in Canada: a Scoping Review. Canadian Journal of Cardiology, 34(4), 437-449. JIF: 5.6

  49. Sun LY, Wijeysundera DN, Tait G, Beattie WS. (2015). Association of Intraoperative Hypotension with Acute Kidney Injury after Elective Noncardiac Surgery. Anesthesiology, 123(3), 515-23. JIF: 6.5

  50. Sun LY, Gershon AS, Ko DT, Thilen SR, Yun L, Beattie WS, Wijeysundera DN. (2015). Trends of Pulmonary Function Testing before Non-Cardiothoracic Surgery in a Population-Based Cohort. JAMA Internal Medicine, 175(8), 1410-2. JIF: 20.8

  51. Barra L, Ha A, Sun L, Fonseca C, Pope J. (2014). Efficacy of biologic agents in improving the Health Assessment Questionnaire (HAQ) score in established and early rheumatoid arthritis: a meta-analysis with indirect comparisons. Clin Exp Rheumatol, 32(3), 333-341.

  52. Sun L, Boodhwani M, Baer H, McDonald B. (2013). The association between tracheostomy and sternal wound infection in postoperative cardiac surgery patients. Canadian Journal of Anesthesia, 60(7), 684-691.

  53. Murphy MJ, Tichauer KM, Sun L, Chen X, Lee TY. (2011). Mean transit time as an index of cerebral perfusion pressure in experimental systemic hypotension. Physiological Measurement, 32(4), 395-405.

Selected Interviews (103 since 2015)

  1. Interviewer: Hazel Tang. (2020, June 27). “I Will Always be a Mathematician at Heart”. AIMed Magazine featured article. https://www.flipsnack.com/AIMed/ai027_aim_magazine_vol3_issue2_2020_text_v4.html

  2. Interviewer: Steve Stiles. (2020, April 15). CABG Bests PCI for Early and Late Outcomes in Evidence-Poor Arena of Severe Systolic Dysfunction.  Medscape.  https://www.medscape.com/viewarticle/928789

  3. Interviewer: Alan Neal. (2019, August 29). Women are more likely than men to die after heart surgery, CBC All in a Day. https://www.cbc.ca/listen/live-radio/1-92-all-in-a-day/clip/15733778-women-are-more-likely-than-men-to-die-after-heart-surgery?share=true

  4. Interviewer: Marcia MacMillan. (2018, September 17). Impact of trans fat ban on heart health. CTV News National. Retrieved from https://www.ctvnews.ca/video?clipId=1490682

  5. Interviewer: Bakalar, N. (2018, July 18). Heart Failure May Be More Lethal in Women. The New York Times. https://www.nytimes.com/2018/07/18/well/heart-failure-may-be-more-lethal-in-women.html?rref=collecti

Orchid ID: http://orcid.org/0000-0003-3381-3115#sthash.diuRDR79.dpuf

Fields of Interest

  • Digital health
  • Health services research
  • Sex and gender epidemiology
  • Heart failure
  • Cardiac surgery and interventions
Back to top