Dr. Ilona S. Skerjanc' Research Group

Posted on Monday, May 2, 2011

The research group led by Dr. Ilona S. Skerjanc, a professor at the Department of BMI, has identified the first kinase that regulates the expression of two important muscle factors (namely MyoD and Myf5) in embryonic stem cells and muscle progenitor stem cells. In a recent publication at EMBO Journal (http://www.ncbi.nlm.nih.gov/pubmed/21556048), Dr. Al-Madhoun and his colleagues delineated the importance of MEF2C phosphorylation and the recruitment of histone acetyltransferases in the lineage specification of skeletal muscle. They further found a non-myosin phosphorylation substrate for the skeletal muscle myosin light chain kinase (skMLCK), which may control the replenishment of muscle stem cells. Their findings provide new insights into skeletal muscle development and have important impact on the clinical treatment.

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