New Evidence Suggests Obesity is Caused by Inflammation, Heart Institute Scientists Say

Posted on Monday, September 28, 2020

Scientists at the University of Ottawa Heart Institute have demonstrated that elevated levels of the RIPK1 gene (Receptor-Interacting serine/threonine Protein Kinase 1), a central regulator of inflammation, is a genetic risk factor for obesity in humans.

Dr. Katey Rayner, the study’s principal investigator, and director of the Cardiometabolic MicroRNA Laboratory at the UOHI, says that by therapeutically silencing “mutant” copies of RIPK1 in a cohort of obese mice, studies have proven to dramatically reduce the fat mass and body weight of the animals and improve their insulin sensitivity, while simultaneously promoting the accumulation of natural killer T-cells that fight inflammation in fat tissue.

To read the full article, and view Dr. Rayner’s video discussing her findings, please click here.

Back to top