Marceline Côté

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Marceline Côté
Associate Professor

BSc, Université de Sherbrooke (2004)
PhD, McGill University (2009)
Postdoctoral Fellow, Brigham and Women's Hospital and Harvard Medical School

Room: Roger Guindon Hall, Room 4510C (office), 4501Q (lab)
Office: 613-562-5800 ext. 8215
Work E-mail: Marceline.Cote@uottawa.ca

Dr. Marceline Côté

Biography

Research Interests

The overarching goal of the Côté laboratory is to improve our understanding of host-pathogen interactions during infection by emerging viruses, towards the development of novel host- and/or viral-oriented antiviral therapeutics. In the laboratory, we combine virological, chemical biology, and genetic approaches to identify host proteins critical for viral infection that can be targeted to block virus spread. We are particularly interested in acquiring a detailed understanding of the entry pathways of filoviruses (Ebola, Marburg viruses and others), arenaviruses (Lassa fever virus), and coronaviruses (Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2, and Middle East respiratory syndrome virus).

Selected Publications

Filovirus Research
  • Ebola virus triggers receptor tyrosine kinase-dependent signaling to promote the delivery of viral particles to entry-conducive intracellular compartments. Stewart CM, Phan A, Bo Y, LeBlond ND, Smith TKT, Laroche G, Giguère PM, Fullerton MD, Pelchat M, Kobasa D, Côté M. PLoS Pathog. 2021 Jan 29;17(1):e1009275. PMID: 33513206
  • Filoviruses Use the HOPS Complex and UVRAG To Traffic to Niemann-Pick C1 Compartments during Viral Entry. Bo Y, Qiu S, Mulloy RP, Côté M. J Virol. 2020 Jul 30;94(16):e01002-20. PMID: 32493822
  • A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells. Stewart CM, Dorion SS, Ottenbrite MAF, LeBlond ND, Smith TKT, Qiu S, Fullerton MD, Kobasa D, Côté M. Viruses. 2019 Mar 1;11(3):206. PMID: 30832223
  • Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry. Qiu S, Leung A, Bo Y, Kozak RA, Anand SP, Warkentin C, Salambanga FDR, Cui J, Kobinger G, Kobasa D, Côté M. Virology. 2018 Jan 1;513:17-28. PMID: 29031163
SARS-CoV-2 Research
  • SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-week interval between doses. Chatterjee D, Tauzin A, Marchitto L, Gong SY, Boutin M, Bourassa C, Beaudoin-Bussières G, Bo Y, Ding S, Laumaea A, Vézina D, Perreault J, Gokool L, Morrisseau C, Arlotto P, Fournier É, Guilbault A, Delisle B, Levade I, Goyette G, Gendron-Lepage G, Medjahed H, De Serres G, Tremblay C, Martel-Laferrière V, Kaufmann DE, Bazin R, Prévost J, Moreira S, Richard J*, Côté M*, Finzi A*. Cell Rep. 2022 Mar 1;38(9):110429. PMID: 35216664 * Co-corresponding authors
  • Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron Benlarbi M*, Laroche G*, Fink C, Fu K, Mulloy RP, Phan A, Ariana A, Stewart CM, Prévost J, Beaudoin-Bussières G, Daniel R, Bo Y, Yockell-Lelièvre J, Stanford WL, Giguère PM, Mubareka S, Finzi A, Dekaban GA, Dikeakos JD, Côté M. bioRxiv. 2022 Feb22. doi: https://doi.org/10.1101/2022.02.19.481107. * Co-first authors

Intracellular vesicular trafficking Research

  • Proximity Interactome Map of the Vac14-Fig4 Complex Using BioID. Qiu S, Lavallée-Adam M, Côté M. J Proteome Res. 2021 Nov 5;20(11):4959-4973. PMID: 34554760
  • From hitchhiker to hijacker: pathogen exploitation of endosomal phosphoinositides. Qiu S, Côté M. Biochem Cell Biol. 2019 Feb;97(1):1-9. PMID: 29746785

For a complete list of publications

 

Fields of Interest

  • Filoviruses
  • Emerging viruses
  • Chemical biology
  • Antiviral drugs
  • Microbiology
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