Mary-Ellen Harper


Mary-Ellen Harper
Professor, University Research Chair in Mitochondrial Bionergetics, Director, Ottawa Institute of Systems Biology and Director of MATRIX (NSERC-Create) (See biography below)

BSc, University of Guelph
PhD, University of Ottawa
Postdoc Cambridge University, UK

Room: Roger Guindon Hall, Room 3510B (office), 3522 (lab)
Office: 613-562-5800 ext. 8458
Lab: 613-562-5800 ext. 8459
Work E-mail:

Dr. Mary-Ellen Harper


Dr. Mary-Ellen Harper is a University Research Chair in Mitochondrial Bionergetics. She is also Director, Metabolomics Advanced Training and International Exchange (Matrix), an NSERC-CREATE program; as well as, Interim Director, Ottawa Institute of Systems Biology


Research Interests

Mammalian Bioenergetics: Metabolic Significance and Control of Uncoupling Proteins

Energy conversion processes in mammalian cells are far from perfect. The research conducted in Dr Harper's laboratory focuses specifically on the metabolic pathways that affect efficiency of energy transduction processes within different cells of the body. The cellular organelle 'charged' with the responsibility of energy conversion is the mitochondrion. It is there that the oxidation of various energy substrates converges for the production of the universal energy currency of cells, ATP. The efficiency of mitochondrial ATP synthesis, or oxidative phosphorylation, varies between different tissues of the body; between different metabolic states; and between different disease states (e.g., thyroid disorders).

The overall aim of the research projects conducted in the Harper lab is to better understand the control of cellular energy transduction processes in health and disease.

In particular, Dr. Harper's laboratory investigates the metabolic significance and control of uncoupling proteins (UCPs). UCPs are a subfamily of the mitochondrial carrier protein family and are located in the mitochondrial inner membrane. They have been hypothesized to cause a mitochondrial proton leak, and thereby allow protons to return to the mitochondrial matrix, bypassing ATP synthase. Thus energy substrates are oxidized, and the energy is released (or "wasted") as heat, instead of being converted to ATP. The function of such seemingly wasteful processes is a major interest of the lab. The role of uncoupling proteins in protection from reactive oxygen species, and cell death, is an expanding research interest of the laboratory group, and has implications for an improved understanding of cell death and aging processes.

Dr. Harper's research group uses integrative approaches spanning from bioenergetic studies of isolated mitochondria, to transfected cell cultures, to transgenic mice, and to clinical investigations. Clinical projects are conducted in collaboration with Dr. Robert Dent (Ottawa Hospital), and Dr. Ruth McPherson (University of Ottawa Heart Institute). Experimental techniques include: gene transfection, transgenics and knockouts, self-referencing microelectrode technologies, metabolic control analysis, oxygen and ion-selective electrodes, real-time PCR, Western blotting, and various forms of fluorescence microscopy.

Graduate Student and Postdoctoral Fellow Supervisions


13 M.Sc. Shadi MONEMDJOU, 1998; Manon GAGNÉ, 1999; Andreas ANTONIOU, 2001; Darcy MacLELLAN 2007; Sean CRAWFORD, 2009; Carmen ESTEY 2009; Adrienne GOWING, 2010; Cynthia MOFFAT, 2010; Rui ZHANG, 2012; Cyril ADJEITEY, 2013, Skye McBRIDE, 2014; Lucien NADEAU, 2017(co-supervised with Dr. Céline Aguer); Awa LIAGHATI, 2017.

8 Ph.D. Shadi MONEMDJOU, 2002; Tia MOFFAT, 2007 (co-supervised with Steffany Bennett); Lisa BEVILACQUA, 2007, Sheila COSTFORD, 2008; Brittany BEAUCHAMP, 2015; Ghadi ANTOUN, 2017 (MD-PhD); Abi RAJKUMAR, 2018 (co-supervised with Dr. Frédérique Tesson); Georges KANAAN, 2018.

10 PDF. Dr. Céline AGUER; Dr. Véronic BEZAIRE; Dr. Martin GERRITS; Dr. Ryan MAILLOUX; Dr. Fiona McMURRAY; Dr. Erin SEIFERT; Dr. Brianne THRUSH; Dr. Neoma BOARDMAN; Dr. Denis BLONDIN; Dr. David PATTEN; Dr. Jens Frey HALLING (visiting for 6 mo from University of Copenhagen)

Current (In progress):

4 PhD.; Rajaa SEBAA; Nidhi KUKSAL; Michel KANAAN; Alessandra GENTILE (visiting from University of Naples)


1 PDF. Dr. Chantal PILEGGI

Undergraduate Research Thesis Student Supervision:

2016-17: Megan MacFarlane; Karan Gandhi; 2015-2016: Bianca ICHIM; Kijoo KIM; Cecile LE; 2014-15: Kris KOMM; Alyssa PEIXOTO; Jessica QUIZI; 2013-14: Olivier CHARETTE; 2012-13: Dhiya HASSAN, William CHEN, 2011-12: Melissa PASQUA, Aline PFEFFERLE; 2010-11: Naveen VENAYAK; 2009-10: Mark BASTIENELLI; Cyril ADJEITEY; Daniela GAMBAROTTA; 2008-9: Marisa ROSSI; Brittany BEAUCHAMP; 2007-8: Sean CRAWFORD, Samantha PREVOST, Benny HILL, Neha SARNA; 2006-7: Carmen ESTEY, Anastasia TOUR; 2005-6: Mitra ABAIEAN, Dimitre RANEV; 2004-5: Basil HUBBARD, Shehla CHAUDHRY; 2003-4: Matthew NIEDZWIECKI, Julie BEAULIEU; 2002-3: Nausheen SIDDIQUI, Marianne McGEE; 2001-2: Audrey NUK, Lorenne DOUCET; 2000-1: Lisa BEVILACQUA; 1999-2000: Veronic BEZAIRE; 1998-9: Andreas ANTONIOU, 1997-8: Shirin LAL; 1996-7: Manon GAGNE, 1995-6: Shadi MONEMDJOU

Current Research Funding

Canadian Institutes of Health Research (CIHR),Natural Sciences and Engineering Research Council (NSERC)  


  • University Research Chair in Mitochondrial Bioenergetics. 2016-2021
  • College of Reviewers, Canadian Institutes of Health Research (CIHR) 2014 -
  • Visiting Research Scholar, Joslin Diabetes Research Center, Harvard Medical School. Boston, MA. Jan. – Dec. 2014
  • Elected as the Canadian Representative on the (North American) Obesity Society Council. 2012-2015
  • Elected to the Board of Governors, Canadian Obesity Network, 2012-
  • Canadian Society for Nutritional Sciences Centrum Award, 2003
  • Laura and Arthur Colwin Endowed Summer Research Fellowship, and HB Steinbach Fellowship in Physiology, Marine Biological Laboratory, Woods Hole, Massachusetts. 2002.
  • Premier's Research Excellence Award, 2000.
  • Canadian Foundation for Innovation Researcher, New Opportunities Award, 1998.
  • John Charles Polanyi Prize - Physiology and Medicine. 1995.
  • Research Associateship, Girton College, University of Cambridge. 1992.
  • Natural Sciences and Engineering Research Council Postdoctoral Fellowship, 1991-3. 

Selected Publications

  • Fiona McMurray*, Megan MacFarlane*, Kijoo Kim*, David A. Patten*, Lan Wei-LaPierre, Morgan D. Fullerton, and Mary-Ellen Harper (2019). Maternal diet induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. FASEB J. In Press.
  • Dmitry Grapov, Oliver Fiehn, Caitlin Campbell, Carol Chandler, Dustin Burnett, Elaine Souza, Gretchen Casazza, Nancy Keim, John Newman, Gary Hunter, Jose Fernandez, W.Timothy Garvey, Charles Hoppel, Mary-Ellen Harper, and Sean H. Adams. Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: impact of a fitness and weight loss intervention. Am J Physiol: Endo Met. In Press.              
  • David A. Patten*, Mathieu Ouelet, David S. Allan, Marc Germain, Stephen Baird, Mary-Ellen Harper+ and Richard B. Richardson+(2019). Mitochondrial adaptation in human mesenchymal stem cells following ionizing radiation.  FASEB J. +Co-senior authors. In Press.
  • Rajaa Sebaa*, Jeff Johnson, Chantal Pileggi*, Michaela Norgren*, Jian Xuan*, Yuka Sai, Qiang Tong, Irena Krystkowiak, Emma Bondy-Chorney, Norman Davey, Nevan Krogan, Michael Downey+ and Mary-Ellen Harper+ (2019). SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1. Molecular Metabolism. 25:35-49 + Co-senior authors. In Press.
  • Chae Young Han; David A Patten*, Se Ik Kim, Jung Jin Lim, David W Chan, Michelle KY Siu, Youngjin Han; Euridice Carmona, Robin J Parks, Cheol Lee, Karen K Chan, Ja-Lok Ku, Elizabeth A Macdonald; Barbara C Vanderhyden, Anne-Marie Mes-Masson, Hextan Y Ngan, Annie N Cheung, Yong Sang Song, Mary-Ellen Harper, and Benjamin K Tsang. (2019) p53 promotes chemoresponsiveness by regulating Hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer, (MS# MC-19-0325). Molecular Carcinogenesis. In Press.
  • Melanie Villanueva, Connor Michie, Georges N Kanaan*, Ghazaleh Rafatian, Pushpinder Kanda, Bin Ye, Wenbin Liang, Mary-Ellen Harper and Darryl R Davis. Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction. Theranostics. (Impact factor 8.1) In press.
  • Skye McBride*, Lan Wei-LaPierre, Fiona McMurray*, Megan MacFarlane*, Xing Qiu, David A. Patten, Robert T. Dirksen RT, Mary-Ellen Harper (2019). Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys. 663:239-248.
  • Sean Delaney, Lisa Julien, Adam Pietrobon, Julien Yockell-Leleievre, Carole Doré, Ting Wang, Valerin Doyon, Angela Raymond, David A. Patten*, Mary-Ellen Harper, Hongyu Sun and William L. Stanford (2019). TSC2-deficiency potentiates a catabolic signaling switch that differentiates neural and neural crest lineage development and progressive disease manifestations. BioRxIV. Published (not peer-reviewed). Preparing for submission at a peer-reviewed journal.
  • Armand Valesia, QP Wang, N Gheldof, J Carayol, H Ruffieux, T Clark, V Shenton, LJ Oyston, G Lefebvre, S Metairon, C Chabert, O Walter, P Mironova, Paulina Lau, P Descombes, N Viguerie, Dominique Langin, Mary-Ellen Harper, Arne Astrup, Wim H Saris, Robert Dent, G Gregory Neely, Jorg Hager. (2019) Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism. Nat Commun. Feb 1;10(1):540. doi: 10.1038/s41467-019-08492-8. PMID: 30710084
  • Majid Nikpay, Kaitlyn Beehler, Armand Valsesia, Jorg Hager, Mary-Ellen Harper, Robert Dent, and Ruth McPherson (2019). Genome-wide identification of circulating-miRNA expression quantitative trait loci reveals the role of several miRNAs in the regulation of cardiometabolic phenotypes. Cardiovascular Research. In Press.
  • Qiao-Ping Wang, Nele Gheldof, Jerome Carayo, Hélène Ruffieux, Teleri Clark, Lisa Oyston, Victoria Shenton, Gregory Lefebvre, Sylviane Metairon, Christian Chabert, Ondine Walter, Polina Mironova, Paulina Lau, Patrick Descombes, Nathalie Viguerie, Dominique Langin, Mary-Ellen Harper, Arne Astrup, Wim Saris, Robert Dent, Greg Neely, and Jorg Hager (2019). Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism. Nature Communications. In Press.
  • Lucien Nadeau*, David Patten*, Audrey Caron, Léa Garneau, Marc Foretz, Pascal Haddad, Barbara G Andersen, Quinn LeBris, Mary-Ellen Harper, and Céline Aguer. (2019) IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation. BBA General Subjects. 1863(2):395-407.
  • Georges Kanaan*, David Patten*, Calum Redpath and Mary-Ellen Harper. (2019) Atrial fibrillation is associated with impaired atrial mitochondrial energetics and supercomplex formation in type 2 diabetes.  Canadian Journal of Diabetes. 43(1):67-75.
  • Zeina Salloum, Eric Lehoux, Mary-Ellen Harper and Isabelle Catalas (2018). Effects of cobalt and chromium ions on oxidative stress and cellular energetics in macrophages in vitro. Journal of Orthopaedic Research. 36(12):3178-3187.
  • Chae Young Han, David A Patten*, Richard Richardson, Mary-Ellen Harper, and Benjamin K. Tsang (2018). Tumor metabolism regulating chemosensitivity in ovarian cancer. Genes and Cancer. 9(5-6):155-175
  • Cominetti O, Núñez Galindo A, Corthésy J, Valsesia A, Irincheeva I, Kussmann M, Saris WHM, Astrup A, McPherson R, Harper ME, Dent R, Hager J, Dayon L (2018). Obesity shows preserved plasma proteome in large independent clinical cohorts. Sci Rep. 8(1):16981. PMID: 30451909
  • Abi Rajkumar*, Awa Liaghati*, Jessica Chan, Gilles Lamothe, Robert Dent, Éric Doucet, Remi Rabasa-Lhoret, Denis Prud’homme, Mary-Ellen Harper** and Frédérique Tesson** (2018). Influence of ACSL5 genotype on fatty acid oxidation and mitochondrial bioenergetics -an in vitro, ex vivo and in vivo analysis. Metabolism Clinical and Experimental. 83:271-279.
  • A. Brianne Thrush*, Ghadi Antoun*, Majid Nikpay, Jean-François Mauger, David Patten*, Brittany L. Beauchamp*, Paulina Lau, Éric Doucet, Pascal Imbeault, Robert Boushel, Jorg Hager, Armand Valsesia, Ruth Slack, Osama Y. Al-Dirbashi, Robert Dent**, Ruth McPherson** and Mary-Ellen Harper. (2018) Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism, Int J Obesity. 42(3):353-362
  • Georges N. Kanaan*, Bianca Ichim*, Lara Gharibeh, Wael Maharsy, David Patten*, Jian Ying Xuan*, Arkadiy Reunov, Philip Marshall, John Veinot, Keir Menzies, Mona Nemer and Mary-Ellen Harper (2018). Glutaredoxin-2 Controls Cardiac Mitochondrial Dynamics and Energetics in Mice, and Protects Against Human Cardiac Pathologies. Redox Biol. 14:509-521.
  • Georges N. Kanaan* and Mary-Ellen Harper (2017) Cellular redox dysfunction in the development of cardiovascular diseases. BBA: General Subjects. 1861: 2822-9.
  • Ghadi Antoun*, Majid Nikpay, Ruth McPherson, Mary-Ellen Harper, and Robert Dent. (2018) Is type 2 diabetes associated with impaired capacity for weight loss? Can J Diabetes. 42(3):313-16.
  • Lisa M. Julian, Sean P. Delaney, Ying Wang, Alex Goldberg, Carole Doré, Julien Yockell-Lelièvre, Roger Y. Tam, Krinio Giannikou, Fiona McMurray*, Molly S. Shoichet, Mary-Ellen Harper, Elizabeth P. Henske, David J. Kwiatkowski, Thomas N. Darling, Joel Moss, Arnold S. Kristof, and William L. Stanford (2017) Human pluripotent stem cell-derived TSC2-haploinsufficient smooth muscle cells recapitulate features of Lymphangioleiomyomatosis. Cancer Research. 77(20):5491-502.
  • Céline Aguer*, Brian Piccolo, Oliver Fiehn, Sean Adams and Mary-Ellen Harper (2017) A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3. FASEB J. 31(2):814-27.
  • Jie Zhang, Alan R Light, Charles Hoppel, Caitlin Campbell, Carol C. Chandler, Dustin Burnett, Elaine Souza, Gretchen Casazza, Ronald Hughen, Nancy Keim, John W. Newman, Gary R. Hunter, Jose Fernandez, W. Timothy Garvey, Mary-Ellen Harper, Oliver Fiehn, and Sean H. Adams. (2017) Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons. Exp. Physiol. 102(1):48-69.
  • Sparks LM, Redman LM, Conley KE, Harper ME, Yi F, Hodges A, Eroshkin A, Costford SR, Gabriel ME, Shook C, Cornnell HH, Ravussin E, Smith SR. (2017) Effects of 12 Months of Caloric Restriction on Muscle Mitochondrial Function in Healthy Individuals. J Clin Endocrinol Metab. 102(1):111-21
  • Mary-Ellen Harper (2016) Drugs and bugs: Turning on the heat through UCP1 and UCP3   J. Physiol. 594(24):7151-2.
  • Fiona McMurray*, David A. Patten* and Mary-Ellen Harper (2016) Reactive Oxygen Species and Oxidative Stress in Obesity – Recent Findings and Empirical Approaches. Obesity. In press. 016-0678.
  • Abi Rajkumar*, Gilles Lamothe, Pierette Bolongo, Mary-Ellen Harper, Kristi Adamo, Eric Doucet, Remi Rabasa-Lhoret, Denis Prud'homme, Frederique Tesson. (2016) Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Team, and Complications Associated with Obesity. BMC Med Genet. Aug 11 2016;17(1):56.
  • Kyle Scott, Maria Benkhalti Jandu, Nicholas D. Calvert, Mathieu Paquette, Li Zhen, Mary-Ellen Harper, Osama Y. Al-Dirbashi, and Jean-Marc Renaud. (2016) KATP channel deficiency in mouse FDB causes an impairment of energy metabolism during fatigue. Am. J. Physiol: Cell. In press. C-00137-2015R3.
  • Amanda Smith, Skye McBride*, Julien L. Marcadier, Jean Michaud, Osama Y. Al-Dirbashi, Jeremy Schwartzentruber, Chandree L. Beaulieu, Sherri L. Katz, FORGE Canada Consortium, Jacek Majewski, Dennis E. Bulman, Michael T. Geraghty, Mary-Ellen Harper, Pranesh Chakraborty , Matthew A. Lines (2016) Severe Neonatal Presentation of Mitochondrial Citrate Carrier (SLC25A1) Deficiency. J. Inher. Metab. Diseases 27: 1-7. June 16, 2016. In press.
  • Mireille Khacho, Alysen Clark, Devon S. Svoboda, Joelle Azzi, Jason G. MacLaurin, Cynthia Meghaizel, Hiromi Sesaki, Diane C. Lagace, Marc Germain, Mary-Ellen Harper, David S. Park, Ruth S. Slack. (2016) Mitochondrial dynamics impacts stem cell identity and fate decisions by regulating a nuclear transcriptional program. Cell Stem Cell. 19(2):232-47.
  • Richard B Richardson and Mary-Ellen Harper. (2016)  Mitochondrial stress controls the radiosensitivity of the oxygen effect: Implications for radiotherapy. Oncotarget. 7(16):21469-83.
  • Brittany Beauchamp* and Mary-Ellen Harper. (2016) In utero undernutrition programs skeletal and cardiac muscle metabolism.  Frontiers in Physiology, 6:401. doi: 10.3389/fphys.2015.00401. PMID: 26779032.
  • Michael A. Kennedy, Tia C. Moffat, Kenneth Gable, Karolina Niewola-Staszkowska, Anne Johnston, Corey Nislow, Linda J. Harris, Robbie Loewith, Mary-Ellen Harper, Teresa Dunn, Steffany Bennett and Kristin Baetz. (2016)  A signaling lipid associated with Alzheimer’s disease causes mitochondrial dysfunction. Scientific Reports. 6:19332. doi: 10.1038/srep19332.
  • Ghadi Antoun*, Skye McBride*, Jason R. Vanstone, Turaya Naas, Jean Michaud, Hugh McMillan, Stephanie Redpath, Dennis Bulman, Jason Brophy, FORGE Canada Consortium, Kym M. Boycott, David Dyment, Martin Holcik, Alex Mackenzie, Mary-Ellen Harper§, and Matthew A. Lines§ (2016)  Detailed Clinical and Bioenergetic Characterization of Mitochondrial Encephalopathy, Cardiomyopathy, and Immunodeficiency due to FBXL4 deficiency. Journal of Inherited Metabolic Diseases. (Co-senior authors). 27:1-9.
  • Mirna Azar, Majid Nikpay, Mary-Ellen Harper, Ruth McPherson, and Robert Dent. (2016) Can response to dietary restriction predict weight loss after Roux-en-Y Gastroplasty?  Obesity.  24(4):805-11.
  • Hussein Daoud, Fiona McMurray*, Andrea Yu, Stephanie Luco, Jason Vanstone, Olga Jarinova, Nancy Carson, Kym M Boycott, Christopher Schofield, Mary-Ellen Harper, David A Dyment, Christine M Armour. (2016) Identification of a Pathogenic FTO Mutation by Next-Generation Sequencing in a Newborn with Growth Retardation and Developmental Delay. Journal of Medical Genetics. 53(3):200-7.
  • Mirna Azar, Majid Nikpay, Mary-Ellen Harper, Ruth McPherson, and Robert Dent. (2015) Adverse Effects of Beta-Blocker Therapy on Weight Loss in Response to a Controlled Dietary Regimen. Can. J. Cardiol. Accepted Oct. 19, 2015. PMID: 26897181.
  • Ghadi Antoun*, Fiona McMurray*, A Brianne Thrush*, David A Patten, Alyssa Christine Peixoto*, Ruth S Slack, Ruth McPherson, Robert Dent, and Mary-Ellen Harper. (2015) Impaired Mitochondrial Oxidative Phosphorylation and Supercomplex Assembly in Rectus Abdominis of Diabetic Obese Individuals. Diabetologia. 58(12):2861-6.
  • Jason Vanstone, Amanda Smith, Skye McBride*, Turaya Naas, Martin Holcik, Ghadi Antoun, Mary-Ellen Harper, Jean Michaud, Erick Sell, Pranesh Chakraborty, Martine Tetreault, Jacek Majewski, Stephen Baird, Kym Boycott, David Dyment, and Alex MacKenzie and Matthew Lines*. (2015) DNM1L-related mitochondrial fission defect presenting as refractory epilepsy.  Eur. J. Human Genetics Accepted Oct. 14, 2015. [Paper #449-15-EJHGRR]
  • Denuja Karunakaran, Laura Richards, Michele Geoffrion, Danyk Barrette, Ryan Gotfrit, Mary-Ellen Harper, and Katey Rayner. (2015) Therapeutic Inhibition of miR-33 Promotes Fatty Acid Oxidation but Does Not Ameliorate Metabolic Dysfunction in Diet-Induced Obesity. Arteriosclerosis, Thrombosis, and Vascular Biology. 35(12):2536-43.
  • Denuja Karunakaran, A. Brianne Thrush*, MA Nguyen, L Richards, Michelle Geoffrion, R Singaravelu, E Ramphos, P Shangari, Michelle Ouimet, John P Pezacki,  Katherine J Moore, L Perisic, L Maegdefessel, U Hedin, Mary-Ellen Harper, Katey J Rayner. (2015) Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and is Enhanced by Anti-miR33 in Atherosclerosis. Circ Res. 117(3):266-78.
  • Brittany Beauchamp*, A. Brianne Thrush*, Jessica Quizi*, Ghadi Antoun*, Nathan McIntosh*, Osama Y. Al-Dirbashi, Mary-Elizabeth Patti, and Mary-Ellen Harper. (2015) Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Biosci Rep. Apr 10;35(3). pii: e00200.
  • Aguer C, McCoin CS, Knotts TA, Thrush AB, Ono-Moore K, McPherson R, Dent R, Hwang DH, Adams SH, Harper ME. Acylcarnitines: potential implications for skeletal muscle insulin resistance. <> FASEB J. 2015 Jan;29(1):336-45. doi: 10.1096/fj.14-255901. Epub 2014 Oct 23.
  • Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS. OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. <> EMBO J. 2014 Nov 18;33(22):2676-91. doi: 10.15252/embj.201488349. Epub 2014 Oct 8.
  • Thrush AB, Zhang R, Chen W, Seifert EL, Quizi JK, McPherson R, Dent R, Harper ME. Lower mitochondrial proton leak and decreased glutathione redox in primary muscle cells of obese diet-resistant versus diet-sensitive humans. <> J Clin Endocrinol Metab. 2014 Nov;99(11):4223-30. doi: 10.1210/jc.2014-1726. Epub 2014 Aug 22.
  • Beauchamp B, Ghosh S, Dysart MW, Kanaan GN, Chu A, Blais A, Rajamanickam K, Tsai EC, Patti ME, Harper ME. Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice. <> Int J Obes (Lond). 2014 Jul 11. doi: 10.1038/ijo.2014.120. [Epub ahead of print]
  • Almontashiri NA, Chen HH, Mailloux RJ, Tatsuta T, Teng AC, Mahmoud AB, Ho T, Stewart NA, Rippstein P, Harper ME, Roberts R, Willenborg C, Erdmann J; CARDIoGRAM Consortium, Pastore A, McBride HM, Langer T, Stewart AF. SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes. <> Cell Rep. 2014 May 8;7(3):834-47. doi: 10.1016/j.celrep.2014.03.051. Epub 2014 Apr 24.
  • Mailloux RJ, Xuan JY, McBride S, Maharsy W, Thorn S, Holterman CE, Kennedy CR, Rippstein P, deKemp R, da Silva J, Nemer M, Lou M, Harper ME. Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions. <> J Biol Chem. 2014 May 23;289(21):14812-28. doi: 10.1074/jbc.M114.550574. Epub 2014 Apr 12.
  • Khacho M, Tarabay M, Patten D, Khacho P, MacLaurin JG, Guadagno J, Bergeron R, Cregan SP, Harper ME, Park DS, Slack RS. Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival. <> Nat Commun. 2014 Apr 1;5:3550. doi: 10.1038/ncomms4550.
  • Campbell C, Grapov D, Fiehn O, Chandler CJ, Burnett DJ, Souza EC, Casazza GA, Gustafson MB, Keim NL, Newman JW, Hunter GR, Fernandez JR, Garvey WT, Harper ME, Hoppel CL, Meissen JK, Take K, Adams SH. Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin. <> PLoS One. 2014 Jan 8;9(1):e84260. doi: 10.1371/journal.pone.0084260. eCollection 2014.
  • Caron AZ, He X, Mottawea W, Seifert EL, Jardine K, Dewar-Darch D, Cron GO, Harper ME, Stintzi A, McBurney MW. The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome. <> FASEB J. 2014 Mar;28(3):1306-16. doi: 10.1096/fj.13-243568. Epub 2013 Dec 2.
  • Mailloux RJ, McBride SL, Harper ME. Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics. <> Trends Biochem Sci. 2013 Dec;38(12):592-602. doi: 10.1016/j.tibs.2013.09.001. Epub 2013 Oct 10. Review.
  • Ryan J. Mailloux*, Skye L. McBride* and Mary-Ellen Harper. (2013)  Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics. Trends in Biochemical Sciences. In Press. MS#: TIBS1017.
  • Cyril Nii-Klu Adjeitey*, Ryan J. Mailloux*, Robert A. Dekemp, Mary-Ellen Harper. (2013) Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production. Am J Physiol Endocrinol Metab. 305(3):E405-15.
  • Céline Aguer*, Oliver Fiehn, Erin L. Seifert*, Véronic Bézaire*, John K. Meissen, Amanda Daniels*, Kyle Scott, Jean-Marc Renaud, Marta Padilla, David R. Bickel, Michael Dysart*, Sean H. Adams, and Mary-Ellen Harper. (2013) Muscle UCP3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete beta-oxidation. FASEB J.  2013/234302.
  • Stephanie Thorn, Michael H Gollob, Mary-Ellen Harper, Rob S Beanlands, Robert A deKemp and Jean N DaSilva (2013) Chronic AMPK Activity Dysregulation Produces Myocardial Insulin Resistance in the Human Arg302Gln-PRKAG2 Glycogen Storage Disease Mouse Model. Eur J Nucl Med Molec Imaging Research.
  • A. Brianne Thrush*, Robert Dent, Ruth McPherson, and Mary-Ellen Harper. (2013) Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity. FEBS J. 2013 Jun 20. In Press. PMID: 23786211.
  • Celine Aguer*, Melissa Pasqua*, Cynthia Moffat*, Michael McBurney, Karen Jardine, Renny Zhang*, Brittany Beauchamp*, Robert Dent, Ruth McPherson, and Mary-Ellen Harper. Increased antioxidant defenses in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes. BBA- Molecular Basis of Disease. Accepted May 5, 2013. In Press. BBADIS-12-441.
  • Anne C. Harasym, A. Brianne Thrush*, Mary-Ellen Harper, David C. Wright, Catherin B. Chan (2013) Enhanced glucose homeostasis in BHE/cdb rats with mutated ATP synthase. Mitochondrion. 13(4):320-329.
  • Robert Davies, Paulina Lau, Thet Naing, Majid Nikpay, Heather Doelle, Mary-Ellen Harper, Robert Dent and Ruth McPherson (2013) A 680 kb duplication at the FTO locus in a kindred with obesity and a distinct body fat distribution. Eur. J. Genetics. doi:10.1038/ejhg.2013.63.
  • Ryan J. Mailloux*, Jian Ying Xuan*, Brittany Beauchamp*, Linda Jui*, Marjorie Lou, and Mary-Ellen Harper Glutaredoxin-2 is required to control proton leak through uncoupling protein-3. J. Biol. Chem.288(12):8365-79.
  • Hang Yin, Alessandra Pasut, Vahab D. Soleimani, C. Florian Bentzinger, Ghadi Antoun*, Stephanie Thorn, Patrick Seale, Pasan Fernando, Wilfred van IJcken, Frank Grosveld, Robert A. Dekemp, Robert Boushel, Mary-Ellen Harper and Michael A. Rudnicki. MicroRNA-133 Controls Brown Adipose Determination by Targeting Prdm16. Cell Metabolism. D-12-00823. Accepted Jan 2, 2013.
  • Ryan J. Mailloux*, Accalia Fu, Christine Robson-Doucette, Emma Allister, Michael B. Wheeler, Robert Screaton, Mary-Ellen Harper. (2012) Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion. J Biol Chem. 2012 Oct 3. [Epub ahead of print] PMID: 23035124.
  • Aline Pfefferle*, Ryan J. Mailloux*, Mary-Ellen Harper. (2012) Glutathionylation of UCP2 sensitizes drug resistant leukemia cells to chemotherapeutics. BBA- Molecular Cell Research. BBAMCR-12-373. In Press. PMID: 23069211.
  • Ryan J. Mailloux* and Mary-Ellen Harper. (2012) Mitochondrial proticity and ROS signaling: Lessons from the uncoupling proteins. Trends in Endo and Metab. 23(9):451-8.
  • Céline Aguer*, and Mary-Ellen Harper. (2012) Skeletal Muscle Mitochondrial Energetics in Obesity and Type 2 Diabetes Mellitus: Endocrine Aspects. Clinical Endocrinology and Metabolism. PMID: 23168281.
  • Michael P. Siegel, T Wilbur, M Mathis, E Shankland, A Trieu, Mary-Ellen Harper, Marcinek DJ. (2012) Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle. Mech Ageing Dev.  Aug 19. PMID: 22935551.
  • Erin L. Seifert*, Mark Bastianelli*, Celine Aguer*, Cynthia Moffat*, Carmen Estey*, Lauren G. Koch, Steven L. Britton, Mary-Ellen Harper. (2012) Intrinsic aerobic capacity correlates with inherent mitochondrial oxidative and H2O2 emission capacities without major shifts in myosin heavy chain isoform. J Appl Physiol. Sep 20. PMID: 22995392
  • Narudee Kashemsant, Septimiu Bucurescu, Mary-Ellen Harper, and Catherine B. Chan. (2012) Impairment of Proinsulin Processing in ß-cells Exposed to Saturated Free Fatty Acid is Dependent on Uncoupling Protein-2 Expression. Canadian Journal of Diabetes.
  • Carmen Estey*, Erin L. Seifert*, Céline Aguer*, Cynthia Moffat* and Mary-Ellen Harper. (2012) Calorie restriction in mice overexpressing UCP3: evidence that prior mitochondrial uncoupling alters response. Experimental Gerontol.  47(5):361-71.
  • Erin L. Seifert*, Annabelle Z. Caron, Katy Morin, Josée Coulombe, Xiao Hong He, Karen Jardine, Danielle Dewar-Darch, Kim Boekelheide, Mary-Ellen Harper, Michael W. McBurney. (2012) SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. FASEB J. 26(2):555-66.
  • Ryan J Mailloux* Cyril Adjeitey*, Jian Xuan* and Mary-Ellen Harper. (2012) Crucial yet divergent roles of mitochondrial redox state in skeletal muscle versus brown adipose tissue energetics. FASEB J. 26(1):363-75.
  • Xun Zhou, Marianna Gomez-Smith, Zhaohong Qin, Philippe Duquette, Arturo Cardenas-Blanco, PS Rai, Mary-Ellen Harper, Eve C Tsai, Hymie Anisman, Hsiao-Huei Chen HH. (2012) Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism. Cell Mol Life Sci. 69(5):819-28.
  • Céline Aguer*, Daniela Gambarotta*, Ryan J. Mailloux*, Cynthia Moffat*, Robert Dent, Ruth McPherson and Mary-Ellen Harper. (2011) Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells. PLoS ONE. 6(12):e28536. I.F.4.1.
  • Ryan J Mailloux* and Mary-Ellen Harper. (2011) Uncoupling proteins and the control of mitochondrial reactive oxygen species production. Free Radical Biology and Medicine. 51(6): 1106-15.
  • James Thackery, Jerry Radziuk, Mary-Ellen Harper, Katherine Ascah, Robert Beanlands, Jean DaSilva. (2011) Sympathetic nervous dysregulation in the absence of left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia. Cardiovascular Diabetology 10(1): 75. PubMed ID: 21831292.
  • Ryan Mailloux*, Erin Seifert*, Frederic Bouillaud, Celine Aguer*, Sheila Collins, Mary-Ellen Harper (2011) Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3. J Biol Chem. 286(24): 21865-75.
  • Mailloux RJ, Dumouchel T, Aguer C, Dekemp R, Beanlands R, Harper ME. Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration. Biochem J. 2011 437 (2): 301-11 PMID: 21554247. Free Article.
  • Mailloux RJ, Seifert EL, Bouillaud F, Aguer C, Collins S, Harper ME. Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3. J Biol Chem. 2011 Jun 17;286(24):21865-75. Epub 2011 Apr 22. PMID: 21515686.
  • Lidell ME, Seifert EL, Westergren R, Heglind M, Gowing A, Sukonina V, Arani Z, Itkonen P, Wallin S, Westberg F, Fernandez-Rodriguez J, Laakso M, Nilsson T, Peng XR, Harper ME, Enerbäck S. The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function. Diabetes. 2011 Feb;60(2):427-35. PMID: 21270254.
  • Ghosh S, Dent R, Harper ME, Gorman SA, Stuart JS, McPherson R. Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity. BMC Med Genomics. 2010 Dec 1;3:56. PMID: 21122113.
  • Mailloux RJ, Adjeitey CN, Harper ME. Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents. PLoS One. 2010 Oct 13;5(10):e13289. PMID: 20967268.
  • Ghosh S, Dent R, Harper ME, Stuart J, McPherson R. Blood gene expression reveal pathway differences between diet-sensitive and resistant obese subjects prior to caloric restriction. Obesity (Silver Spring). 2011 Feb;19(2):457-63. PMID: 20885385.
  • Scimè A, Soleimani VD, Bentzinger CF, Gillespie MA, Le Grand F, Grenier G, Bevilacqua L, Harper ME, Rudnicki MA. Oxidative status of muscle is determined by p107 regulation of PGC-1alpha. J Cell Biol. 2010 Aug 23;190(4):651-62. PMID: 20713602.
  • Gerrits MF, Ghosh S, Kavaslar N, Hill B, Tour A, Seifert EL, Beauchamp B, Gorman S, Stuart J, Dent R, McPherson R, Harper ME. Distinct skeletal muscle fiber characteristics and gene expression in diet-sensitive versus diet-resistant obesity. J Lipid Res. 2010 Aug;51(8):2394-404. PMID: 20332421.
  • Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS. Hum Mol Genet. 2010 Oct 1;19(19):3734-46.  PMID: 20639397.
  • Crawford SA, Costford SR, Aguer C, Thomas SC, deKemp RA, DaSilva JN, Lafontaine D, Kendall M, Dent R, Beanlands RS, McPherson R, Harper ME. Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes. Diabetologia. 2010 Sep;53(9):1986-97. PMID: 20473479.
  • Mailloux RJ, Harper ME. Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase. FASEB J. 2010 Jul;24(7):2495-506.  PMID: 20228249.
  • Erin Seifert*, Carmen Estey*, Jian Xuan* and Mary-Ellen Harper. Electron transport chain-dependent and independent mechanisms of mitochondrial H202 emission during long-chain fatty acid oxidation. J. Biol. Chem. 2010 Feb. 19, 285(8):5748-58. E pub Accepted Dec 23, 2009. PMID: 20032466.
  • Sheila Costford*, Sean Crawford*, Robert Dent, Ruth McPherson, and Mary-Ellen Harper. (2009) Increased Susceptibility to Oxidative Damage in Post-Diabetic Human Myotubes.  Diabetologia52:2405-2415.
  • Graham Holloway, Swati Jain, Veronic Bezaire*, Xiao-Xia Han, Jan Glatz, Joost Luiken, Mary-Ellen Harper, and Arend Bonen. (2009) FAT/CD36 null mice reveal that mitochondrial FAT/CD36 is required to up-regulate mitochondrial fatty acid oxidation in contracting muscle. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 297(4):R960-967.
  • Michael Greene, James T. Thackeray, Miran Kenk, Stephanie L. Thorn, Lisa Bevilacqua*, Mary-Ellen Harper, Robert S. Beanlands, and Jean DaSilva (2009) Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats. Can J Physiol and Pharmacol.87: 196-202.
  • Sheila Costford*, Shehla Chaudhry*, Mahmoud Salkhordeh* and Mary-Ellen Harper (2008). Long-Term High Fat Feeding Induces Greater Fat Storage in Mice Lacking UCP3.  Am J. Physiol: Endo & Met.295(5):E1018-24.
  • Erin Seifert*, Veronic Bezaire* Carmen Estey* and Mary-Ellen Harper (2008). Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export.  J Biol Chem. 283(37): 25124-31.
  • Gino Boily, Erin L. Seifert*, Lisa Bevilacqua*, Xiao Hong He, Guillaume Sabourin, Carmen Estey*, Cynthia Moffat*, Sean Crawford*, Sarah Saliba*, Karen Jardine*, Jian Xuan*, Meredith Evans*, Mary-Ellen Harper and Michael W. McBurney. (2008) SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS ONE. Mar 12;3(3):e1759. PMID: 18335035.
  • Erin L. Seifert* and Mary-Ellen Harper. (2008) Thyroid effects on mitochondrial function. Thyroid.  18(2):145-56.
  • Mary-Ellen Harper, Katherine Green and Martin D. Brand. (2008) The efficiency of cellular energy transduction and its implications for obesity. Ann Rev Nutrition. 28:13-33.
  • Monique C. Saleh, Zahra Fatehi-Hassanabad, Rennian Wang, Rodolpho Nino-Fong, Dorota W. Wadowska, Glenda M. Wright, Mary-Ellen Harper and Catherine B Chan. (2008) Mutated ATP synthase induces oxidative stress and impaired insulin secretion in ß-cells of female BHE/cdb rats.  Diabetes/Metabolism Research and Reviews. 24(5):392-403.
  • Sheila Costford*, Nihan Kavaslar, Nadav Ahituv, Shehla N. Chaudhry*, Wendy S. Schackwitz, Robert Dent, Len A. Pennacchio, Ruth McPherson and Mary-Ellen Harper. (2007) Gain-of-Function R225W Mutation in Human AMPKγ3 Causing Increased Glycogen and Decreased Triglyceride in Skeletal Muscle. PLoS ONE. Sep 19; 2(9):e9032007.
  • Sheila Costford*, Adrienne Gowing* and Mary-Ellen Harper. (2007) Mitochondrial uncoupling as a target in the treatment of obesity.  Current Opinion in Clinical Nutrition and Metabolic Care. 10(6):671-678.
  • Andrew N. Carley, Laura Atkinson, Arend Bonen, Mary-Ellen Harper, Stanley Kunnathu, Gary D. Lopaschuk and David L. Severson. (2007) Mechanisms responsible for enhanced fatty acid utilization by perfused hearts from type 2 diabetic db/db.Archives of Physiology and Biochemistry. 113 (2): 65-75.
  • Sheila Costford, Erin L. Seifert, Veronic Bezaire, Martin Gerrits, Lisa Bevilacqua, Adrienne Gowing and Mary-Ellen Harper. (2007) The energetic implications of uncoupling protein-3 in skeletal muscle. J. Appl. Physiol. Nutr. Metab.
  • Kristi Adamo, Robert Dent, Carl Langefeld, Cox M, Williams K, Carrick KM, Joan S Stuart, Scott S. Sundseth, Mary-Ellen Harper, Ruth McPherson, and Frederique Tesson. (2007) Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response. Obesity Res. 15(5):1068-75.
  • Veronic Bezaire, Erin Seifert and Mary-Ellen Harper. Uncoupling protein-3: Clues in a mitochondrial mystery. FASEB J. 21(2):312-24.
  • Sheila Costford*, Shehla N. Chaudhry*, Mahmoud Salkhordeh*, Mary-Ellen Harper. (2006) Effects of the Presence, Absence and Overexpression of Uncoupling Protein-3 on Adiposit and Fuel Metabolism in Congenic Mice. Am J. Physiol Endocrinol Metab. 290(6):E1304-12.
  • Cathy B. Chan and Mary-Ellen Harper (2006) Uncoupling proteins: Roles in insulin resistance and insulin insufficiency. Current Diabetes Reviews. 2(3):271-283.
  • Anthony Scime, Guillaume Grenier, Michael S. Huh, Mark A. Gillespsie, Lisa Bevilacqua, Mary-Ellen Harper and Michael A. Rudnicki (2005) Rb and p107 Regulate Preadipocyte Differentiation into White versus Brown Fat through Repression of PGC-1alpha. Cell Metaolism 2(5): 283-95.
  • Jagdeep Sandhu, Caroline Sodja, Kevan McRae, Yan Li, Peter Ripstein, Yau-Huei Wei, Boleslaw Lach, Fay Lee, Septimiu Bucurescu*, Mary-Ellen Harper, and Marianna Sikorska, (2005) Effects of nitric oxide donors on cybrids harboring the mitochondrial myopathy, encephalopathy, lacticacidosis and stroke like episodes (MELAS) A324G mitochondrial mutation. Biochem J. 391(2): 191-202.
  • Darcy McLellan*, Adrienne Gowing*, Martin Gerrits*, Peter Smith, Michael Wheeler and Mary-Ellen Harper (2005). Physiological increases in uncoupling protein-3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.Diabetes. Aug; 54(8): 2343-50.
  • Lisa Bevilacqua*, Jon J. Ramsey, Kevork Hagopian, Richard Weindruch and Mary-Ellen Harper. (2005) Muscle mitochondrial proton leak and reactive oxygen species production in muscle mitochondria after long-term caloric restriction. Am J Physiol: Endo & Met. 289(3): E429-438.
  • Veronic Bezaire*, Lawrence Spriet, Shannon Campbell, Nicole Sabet*, Martin Gerrits* Arend Bonen and Mary-Ellen Harper. (2005) Constitutive overexpression of UCP3 at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation. FASEB J.  19(8):977-979.
  • Daniel E Rusyniak, Stephany L.Tandy, S. K. Hekmatyar, Edward Mills, David J. Smith, Navin Bansal, Darcy MacLellan*, Mary-Ellen Harper, and Jon E. Sprague. (2005) The role of mitochondrial uncoupling in 3,4-methylene­dioxy­meth­amphetamine mediated skeletal muscle hyperthermia and rhabdomyolysis. J. Pharmacol Exp Therapeut. 313(2): 629-639.
  • Marc Riachi*, Jean Himms-Hagen, Mary-Ellen Harper (2004) Percent relative cumulative frequency (PRCF) analysis in indirect calorimetry: Application to studies of transgenic mice Can J Physiol Pharmacol. 82(12):1075-83.
  • Mary-Ellen Harper, Lisa Bevilacqua*, Kevork Hagopian, Richard Weindruch, Jon J Ramsey. (2004) Aging, oxidative stress and mitochondrial uncoupling. Acta Physiol Scand. 182:321-331.
  • Lisa Bevilacqua*, Jon Ramsey, Kevork Hagopian, Richard Weindruch, and Mary-Ellen Harper (2004) Effects of short-and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. AJP: Endo Metab. 286(5):E852-61.
  • Éric Doucet, Marjorie Pomerleau and Mary-Ellen Harper. (2004) Effects of a short-term energy restricted diet on fasting and postprandial ghrelin. J. Clin Endocrinol Metab 89(4):1727-32.
  • Pascal Imbeault, Marjorie Pomerleau, Mary-Ellen Harper and Éric Doucet. (2004) Unchanged fasting and postprandial adiponectin levels following a 4-day caloric restriction in young healthy men. Clin Endocrinol (Oxf). 60(4):429-33.
  • Jon J Ramsey, Kevork Hagopian, Teresa M. Kenny, Edward K Koomson, Lisa Bevilacqua*, Richard Weindruch, and Mary-Ellen Harper. (2004) Proton leak and hydrogen peroxide production in liver mitochondria from energy restricted rats. AJP: Reg Integr. 286: E31-40.
  • Xiaotuan Liu, Martin Rossmeisel, Jennifer McClaine, Marc Riachi*, Mary-Ellen Harper and Leslie P. Kozak. (2003) Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J. Clin. Invest. 111:399-407. Erratum: 111:759.
  • Mary-Ellen Harper, Andreas Antoniou* Elizabeth Villalobos-Menuey, Alicia Russo, Richard Trauger, Minda Vendemelio, Azhar Shaikh* Jami Kupperman, Evan W. Newell, Ivan A. Bespalov, Susan S. Wallace, Ye Liu, Jeffrey Rogers, Gregory Gibbs, Sandra Berry-Lowe, Jack L. Leahy, Robert Melamede, and M. Karen Newell (2002).  Characterization of a Novel Metabolic Strategy Used by Drug Resistant Tumor Cells. FASEB J. 16:1550-1557.
  • Mary-Ellen Harper, Robert Dent, Shadi Monemdjou*, Véronic Bézaire*, Lloyd VanWyck, George Wells, Gul Nihan Kavaslar, Andre Gauthier, Frédérique Tesson and Ruth McPherson (2002)  Decreased mitochondrial proton leak and reduced expression of Ucp3 in skeletal muscle of obese diet-resistant women.  Diabetes. 51: 2459-2466.
  • George Argyropoulos and Mary-Ellen Harper (2002)  Uncoupling proteins and thermoregulation, J. Appl. Physiol. 92: 2187-2198.
  • Veronic Bezaire*, Wolfgang Hofmann, John K.G.Kramer, Leslie P. Kozak and Mary-Ellen Harper. (2001) Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3 -/- and wild-type mice Am. J. Physiol,. 281(5):E975-82.
  • Mary-Ellen Harper and Jean Himms-Hagen (2001) Mitochondrial efficiency: Lessons learned from transgenic mice. Biochim. Biophys. Acta: Bioenergetics. 1504: 159-172.
  • Jean Himms-Hagen and Mary-Ellen Harper (2001) Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates. Exp. Biol. Med. 226:78-84.
  • Kyoko Tsukiyama-Kohara, Francis Poulin, Michinori Kohara, Christine DeMaria, Alan Cheng, Anne-Claude Gingras, Asao Katsume, Mounib Elchebly, Mary-Ellen Harper, Michel Tremblay and Nahum Sonenburg (2001) Decreased adipose tissue and increased metabolism in mice lacking the translational inhibitor 4EBP1. Nature Medicine. 7:1-5.
  • Wolfgang E. Hofmann, Xiaotuan Liu, Christie M. Bearden, Mary-Ellen Harper, and Leslie P. Kozak (2001) Effects of genetic background on thermoregulation and fatty acid induced uncoupling of mitochondria in UCP1-deficient mice. J. Biol. Chem. 276(15):12460-12465.
  • Shadi Monemdjou*, Wolfgang E. Hofmann, Leslie P. Kozak and Mary-Ellen Harper (2000) Increased mitochondrial proton leak in skeletal muscle mitochondria of UCP1-deficient mice. Am. J. Physiol.: Endocrinol. Metab. 279:E941-E946.

Fields of Interest

  • Mitochondrial energetics
  • Uncoupling proteins
  • Reactive oxygen species
  • Glutathione redox
  • Oxidative stress
  • Metabolic disease
  • Obesity
  • Diabetes
  • Biochemistry
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