Candidatures et postes

Description:

The lab of Derrick Gibbings at the University of Ottawa is hiring scientists or research technicians with a background in cellular, molecular or disease biology. The successful candidate(s) will join a substantial team of other scientists and graduate students with a focus on understanding fundamental mechanisms of disease and developing new classes of therapeutics. In particular, the successful candidate(s) will be primarily involved in working with a subgroup working on delivery of therapeutics by extracellular vesicles. Expertise in cell biology, RNA biology, molecular biology, extracellular vesicles or animal models would be valuable.

Duration: One year contract with indefinite renewals. Six month probationary period.

Schedule: Flexible schedules can be arranged with the supervisor.

Requirements

Minimum Qualifications

• B.Sc. or advanced diploma in biological sciences
• Independent and highly motivated
• Self-organized
• Works productively in a team
• Creativity and critical analysis

To apply:

Please send your application, including a curriculum vitae and a cover letter to gibbings@uottawa.ca

Description:

A postdoctoral fellow position is available in the laboratory of Dr. Nongnuj Tanphaichitr, Ottawa Hospital Research Institute (OHRI), to carry out a new research project. In this study, the candidate will develop dosage formulation (delivery system) of antimicrobial peptides (AMPs) to be administered intravaginally. We will focus on the cathelicidin AMP, LL-37, and its derived peptide, 17BIPHE2, which possess both spermicidal and microbicidal activity (Kiattiburut et al., Human Reprod 2018, 33:2175-2183). As Multipurpose Prevention Technology (MPT) agents, these AMPs will provide women with empowerment to protect themselves against unwanted pregnancies and sexually transmitted infections. This study is funded by Canadian Institutes of Health Research (CIHR) and is being carried out in both mouse (in vitro and in vivo) and human (in vitro and ex vivo) systems.

Requirements

Candidates must have a Ph.D. in biochemistry, cell biology/physiology or related biomedical fields with ability to communicate well at both oral and written levels. Knowledge and lab experience in the female reproductive physiology, sperm biology, and hydrogel and/or nanoparticles-based drug delivery to the vagina will give priorities in the recruitment. Self-motivation to progress in his/her career as an independent investigator will also be favorably considered.

Salary:

Salary and benefits will be commensurate with the candidate’s experience, following the guideline of OHRI. The term of employment can be up to 4 years. OHRI is one of the foremost Canadian hospital-based research institutes with investigators performing research focusing on answering important health questions and translating their findings into benefits for mankind. A sizable group of researchers in the field of reproductive biology are members of OHRI and also other academic institutes in Ottawa.

To apply:

Please send your CV with description of research experience and names of three references to ntanphaichitr@ohri.ca

General Information:

An MSc position is open in the Tóth lab to conduct structure-function studies on a newly discovered cellular organelle (Anastasia et al. Cell Reports, 2021). The candidate will learn to use state-of-the-art imaging methodologies such as electron tomography to reconstruct the various compartments of the cell in 3D. In addition, they will learn how to design, test, and analyze quantitative electron microscopy data and present them to both scientific and external audiences. Through this research program, the candidate will learn to recognize, evaluate, and solve any complex problem using the scientific method. The student will be part of a highly dynamic and collaborative project.

Please, send your CV to ktoth@uottawa.ca

Description:

The focus of the project is on the large-scale analysis of multi-omics datasets from human gut microbiome in the context of pediatric inflammatory bowel diseases. The goal of the project is to integrate the results of metagenomics, metatranscriptomics and metaproteomics datasets in a machine learning framework to identify predictive signatures of treatment responses in inflammatory bowel disease patients and classify them accordingly.

This research will take place at the Faculty of Medicine of the University of Ottawa. Ottawa is considered to be one of the best livable cities on the globe.

Basic Requirements:

Basic Requirements (Education/Experience):

The ideal candidate should:

• Have a Ph.D. in Bioinformatics, Computational Biology, Machine Learning, Biostatistics, Genomics, or a related field
• Have experience with omics data analysis from next-generation sequencing technologies
• Have knowledge and experience with large-scale biological data analysis
• Have experience in analyzing clinical datasets
• Have experience in the computational analysis of large biological datasets such as ENCODE and TCGA.
• Be experienced with machine learning techniques applied to large biological datasets
• Have proficiency in a programming language such as Java, C, C++, Python, R or Matlab.
• Be comfortable in a Linux environment.
• Be a team player
• Have the ability to work independently
• Have strong written and verbal communication skills and a good ability to communicate with colleagues in biological sciences
• Have a strong publication record.Additional assets considered for this position:
• Have experience in proteomics data analysis
• Have a working knowledge of annotation databases such as Gene Ontology, GeneCards, Ensembl, and Reactome
• Have experience working in a collaborative and multidisciplinary team environment

Start date and Salary:

Start Date: As soon as possible

Salary: $50,000 CAD/year with benefits

To apply:

Please submit a complete CV, a cover letter and the names and contact information of three references to Dr. Mathieu Lavallée-Adam at this address: mathieu.lavallee@uottawa.ca

General Information:

Postdoctoral positions are available in the laboratory of Dr. Xiaohui Zha at Ottawa Hospital Research Institute/University of Ottawa*, Canada (http://www.ohri.ca/profile/Zha).

Project Description:

The project is to study the mechanisms by which cholesterol regulates macrophage inflammation, a key event in atherosclerosis. Cholesterol, a major component of the plasma membrane in mammalian cells, predominantly regulates membrane physical properties. Most likely through its modulation of cellular membranes, cholesterol impacts numerous signal transduction pathways and cellular processes. Particularly, cholesterol levels in macrophages determine the nature of the inflammation response, for example, pro-inflammatory response (M1), anti-inflammatory (M2) or anything in between. The mechanism is largely unknown. In recent years, it is increasingly apparent that macrophages can respond to environmental cues to establish an epigenetically “poised” state. This allows macrophages to rapidly launch a large-scale gene expression program upon stimulation (i.e. LPS). The project will use biochemistry and genomic techniques, such as RNA-seq and ChIP-seq, to understand how cholesterol establishes epigenetically “poised” states in the genome of the macrophages to regulate gene expression for inflammatory responses.

Basic Requirements:

Candidates should be a fresh PhD (less than two years since graduation) in physical science or biological science with good publication record. Knowledge/experience in genomic system biology is a plus, but not necessary. If interested, please send curriculum vitae and brief statement of research interest to xzha@ohri.ca .

Contact info:

Xiaohui Zha, Senior Scientist
Chronic Disease Program
Ottawa Hospital Research Institute
501 Smyth Road, Ottawa, ON K1H 8L6
 

*The Ottawa Hospital Research Institute is the research arm of The Ottawa Hospital and an affiliated institute of the University of Ottawa. With more than 1,700 scientists, clinician investigators, trainees and staff, and total revenues of more than $100 million, it is one of the foremost Canadian hospital-based research institutes. Researcher are investigating virtually every major disease and condition, with a focus on answering important health questions and translating our findings into benefits for patients and society.