Lisheng Wang

Biographie

Notice biographique

Le professeur Lisheng Wang est membre du Département de biochimie, microbiologie et immunologie de l’Université d’Ottawa. Membre principal de l’Institut de la biologie des systèmes d’Ottawa et chercheur affilié à l’Institut de recherche de l'Hôpital d’Ottawa, le professeur Wang a obtenu son diplôme de l’école de médecine en Chine. Il compléta ensuite sa formation clinique postdoctorale à l’Unité nationale australienne de transplantation hépatique. Le professeur Wang obtint son doctorat à l’Université de Sydney (Australie) sur l’étude des facteurs immunologiques impliqués dans la transplantation. Il poursuivit ses recherches postdoctorales en immunologie à Harvard Medical School (USA), ainsi que des recherches postdoctorales en biologie des cellules-souches et en médecine régénératrice au Robarts Research Institute (Canada).

Intérêts de recherche

En utilisant des approches de la biologie cellulaire et moléculaire ainsi que des modèles animaux, le laboratoire du professeur Wang s’intéresse à

1. Conditionner les cellules-souches embryonnaires humaines (CSEh) à devenir des progénitures de cellules circulatoires et immunitaires pour établir de nouvelles thérapies basées sur des cellules-souches et réduire le rejet de greffe ;
2. Cibler les voies de signalisation liées au développement embryonnaire dans le cancer du sein afin d’améliorer l’efficacité du traitement.

Pour plus d’informations, veuillez contacter le professeur Lisheng Wang par téléphone : 613-562-5624 ou par courriel : lwang@uottawa.ca

 

Publications sélectionnées

• Deyong Jia, Yuan Tan, Huijuan Liu, Sarah Ooi, Li Li, Kathryn Wright, Steffany Bennett, Christina L. Addison, Lisheng Wang. Cardamonin reduces chemotherapy-enriched breast cancer stem-like cells in vitro and in vivo. Oncotarget 2015 DOI: 10.18632/oncotarget.5819.
• Yuan Tan, Bodour AlKhamees1, Deyong Jia, Li Li, Jean-François Couture, Daniel Figeys, Masahisa Jinushi*, Lisheng Wang * (*corresponding authors). MFG-E8 is critical for embryonic stem cell-mediated T cell immunomodulation. Stem Cell Reports 2015; 5: 741–752.
• Deyong Jia, Weixia Yang, Li Li, Huijuan Liu, Yuan Tan, Sarah Ooi, Lingyi Chi, Lionel G. Filion, Daniel Figeys, Wang L. β-catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death and Differentiation 2015 Feb; 22(2):298-310. doi:10.1038/cdd.2014.145.Epub 2014 Sep 26
• Huang T, Li L, Moalim-Nour L, Jia D, Jian B, Yao, Z, Bennett S, Figeys D, Wang L. A regulatory network involving β-catenin, E-cadherin, PI3K/Akt, and Slug balances self-renewal and differentiation of human pluripotent stem cells in response to Wnt signaling. Stem Cells 2014 Dec 23. doi:10.1002/stem.1944 [Epub ahead of print].
• Tan Y, Ooi S, Wang L. Immunogenicity and tumorigenicity of pluripotent stem cells and their derivatives: genetic and epigenetic perspectives. Curr Stem Cell Res Ther. 2014 Jan;9(1):63-72. Review.
• Mohib K, Wang L. Differentiation and characterization of dendritic cells from human embryonic stem cells. Current Protocol in Immunology 2012; Chapter 22:Unit 22F 11
• Mohib K, AlKhamees B, Mostafa Haggag Salah Zein, Allan D, Wang L. Embryonic stem cell-derived factors inhibit T effector activation and induce T regulatory cells by modulating PKC-θ activation. PLoS ONE 2012: 7(3): e32420
• Tian R#, Wang S# (#equal contribution), Elisma F, Li L, Zhou H, Wang L*, Figeys D* (*correspondence authors). Rare Cell Proteomic Reactor Applied to Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Quantitative Proteomics Study of Human Embryonic Stem Cell Differentiation  (1.67 MB). Mol Cell Proteomics. 2011 Feb;10(2):M110.000679. Epub 2010 Jun 8
• Mohib K, Allan D, Wang L. Human embryonic stem cell-extracts inhibit the differentiation and function of monocyte-derived dendritic cells  (382 KB). (Original research article) Stem Cell Rev. 2010 Dec; 6(4):611-21
• Li L#, Wang S#, Jezierski A# (# equal contribution), Moalim-Nour L, Mohib K, Parks RJ, Francesco Retta S, Wang L. A unique interplay between Rap1 and E-cadherin in the endocytic pathway regulates self-renewal of human embryonic stem cells. Stem Cells 2010; 28: 247-257 (Top downloaded articles in Stem Cells in February 2010)
• Li L, Wang BH, Wang S, Moalim-Nour L, Mohib K, Lohnes D, Wang L. Individual cell movement, asymmetric colony expansion, Rho-associated kinase and E-cadherin impact the clonogenic assay of human embryonic stem cells  (1.05 MB). Biophysical Journal2010; 98: 2442-2551 (Featured article).
• Zhong S, Magnolo AL, Sundaram M, Zhou H, Yao EF, Leo ED, Loria P, Wang S, Bamji-Mirza M, Wang L, McKnight J, Figeys D, Wang Y, Tarugi P, and Yao Z. Nonsynonymous mutations within APOB in human hypobetalipoproteinemia: Evidence for feedback inhibition of lipogenesis and post-endoplasmic reticulum degradation of apolipoprotein B. J Biol Chem  2009; Dec 23: PMID: 20032471 (Epub ahead of print).
• Wang L. Endothelial and hematopoietic cell fate of human embryonic stem cells. Trends in Cardiovascular Medicine  (176 KB). 2006; 16:89-94.
• Menendez P, Bueno C, Wang L. Human embryonic stem cells: A journey beyond cell replacement therapies. Cytotherapy. 2006; 8(6):530-41.
• Cerdan C, Bendall SC, Wang L, Stewart M, Werbowetski T, Bhatia M. Complement targeting of nonhuman sialic acid does not mediate cell death of human ESCs. Nature Medicine 2006; 12: 1113-1114.
• Wang L*, Menendé P* (*equal contribution), Shojaei F, Li L, Mazurier F, Dick JE, Cerdan C, Levac K, Bhatia M. Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HoxB4 expression. Journal of Experimental Medicine 2005; 201: 1603-1614
• Wang L, Li L, Menendez P, Cerdan C, Goodale D, Bhatia M. Human embryonic stem cells maintained in the absence of mouse embryonic fibroblasts or conditioned media are capable of hematopoietic development. Blood 2005; 105: 4598-4603.
• Roura-Mir C*, Wang L* (* equal contribution), Cheng TC, Matsunaga I, Dascher C, Peng S, Fenton MJ, Moody DB. M. tuberculosis regulates CD1 antigen presentation pathways through TLR-2. Journal of Immunology2005; 175:1758-1766.
• Wang L, Menendez P, Cerdan C, Bhatia M. Hematopoietic cells from human embryonic stem cells. Experimental Hematology (Review) 2005; 33:987-96
• Menendez P, Bueno C, Wang L, Bhatia M. Human Embryonic Stem Cells: Potential tool towards achieving immunotolerance? Stem Cell Reviews 2005; 1: 151-158..
• Menendez P, Wang L, Bhatia M. Genetic manipulation of human embryonic stem cells: a powerful approach for studies in human development and potential therapeutic applications. Current Gene Therapy (Review) 2005; 5: 375-85.
• Wang L, Li L, Shojaei F, Levac K,Cerdan C,Menendez P, Martin T, Rouleau A, Bhatia M. Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Immunity 2004; 21: 31-41.
• Menendez P, Wang L, Chadwick K, Li L & Mickie Bhatia. Retroviral transduction of hematopoietic cells differentiated from human embryonic stem cell-derived CD45 negPFV hemogenic precursors. Molecular Therapy 2004; 10: 1109-1120.
• Chadwick K*, Wang L* (*equal contribution), Li L, Menendez P, Murdoch B, Rouleau A, Bhatia M. Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood 2003; 102: 906-915. (Comment) in Blood 2003; 102: 776.
• Kamath A, Wang L, Das H, Lin L, Reinhold VN, Bukowski JF. Tea Drinking Enhances Immunity to Microbial Antigens by Priming gd T Cells in vivo. Proc. Natl. Acad. Sci. U. S. A.2003; 100: 6009-6014.
• Wang L, Das H, Kamath A, Lin L, Bukowski JF. Human V g2V d2 T cells augment Migration-inhibitory factor secretion, and counteract the inhibitory effect of glucocorticoids on IL1- b and TNF- a production. Journal of Immunology 2002; 168: 4889-4896.
• Wang L, Kamath A, Das H, Lin L, Bukowski JF. Antibacterial effect of human V g2V d2 T cells in vivo. Journal of Clinical Investigation 2001; 108: 1349-1357.
• Wang L, Das H, Kamath A, Bukowski JF. Human V g2V d2 T cells produce IFN- g and TNF- a with an on/off/on cycling pattern in response to live bacterial products. Journal of Immunology 2001; 167: 6195-6201.
• Das H, Wang L, Kamath A and Bukowski JF. V g 2 d 2 T cell receptor–mediated recognition of aminobisphosphonate. Blood2001; 98(5): 1616-1618.