Dr. Dimitrios Mitsouras


Dr. Dimitrios Mitsouras
Associate Professor, Department of Biochemistry, Microbiology and Immunology

B.Sc. Computer Science, Brown University
M.Sc. Electrical Engineering and Computer Science, MIT
Ph.D. Electrical Engineering and Computer Science, MIT

Room: 501 Smyth Road, CPCR Bldg, L2107
Office: 613-798-5555 ext. 73662
Work E-mail: d.mitsouras@uottawa.ca

Dr. Dimitrios Mitsouras



Dr. Mitsouras joined the University of Ottawa in July 2017 as an Associate Professor in the Faculty of Medicine. Prior to his current position, Dr. Mitsouras was an Assistant Professor at the Harvard Medical School where he co-founded and later directed the internationally-recognized Applied Imaging Science Lab at Brigham and Women’s Hospital. Dr. Mitsouras has published >70 peer-reviewed articles and has been awarded >$1M USD of extramural funding from the U.S. National Institutes of Health, the American Heart Association, and commercial entities in support of his research.

Research Interests

Dr. Mitsouras’ research focuses on developing novel biomedical imaging technologies that empower physicians to better detect, quantify, and visualize disease toward improving the quality of life of their patients. He has formed and led collaborative multi-disciplinary teams that have developed diverse methods now incorporated in clinical magnetic resonance and computed tomography systems. These include the precursor to the 3D SPACE magnetic resonance (MR) imaging sequence used to perform high resolution selective three-dimensional (3D) imaging throughout the body in clinically-viable scan times, the introduction of wide-area volume computed tomography (CT) in clinical practice and the subsequent discovery of flow information embedded in arterial contrast enhancement patterns in CT angiography images which has led to improved techniques to assess the hemodynamic significance of coronary artery disease using computational fluid dynamics (so-called CT-FFR techniques), and 3D printing technologies to guide patient-specific precision surgery.

Dr. Mitsouras’ lab is currently working to (a) establish optimal computational physiologic models to non-invasively assess the hemodynamic significance of coronary artery disease and predict the risk of plaque rupture which can lead to myocardial infarction and death, and (b) accelerate personalized precision medicine via 3D virtual and printed models to enable optimal therapy planning and delivery for cardiac, vascular, oncologic, and orthopedic surgery patients.

Select Publications

  • George E, Liacouras P, Lee TC, Mitsouras D. 3D-Printed Patient-Specific Models for CT- and MRI-Guided Procedure Planning. AJNR Am J Neuroradiol. 2017;in press
  • Porras D, Mitsouras D, Steigner ML, Giannopoulos AA, Kelil T, Marshall AC, Menard MT. Transcatheter Mustard Revision using Endovascular Graft Prostheses. Ann Thorac Surg. 2017;103(6):e509-12
  • George E, Liacouras P, Rybicki FJ, Mitsouras D. Measuring and Establishing the Accuracy & Reproducibility of 3D-Printed Medical Models. RadioGraphics 2017;in press
  • George E, Barile M, Tang A, Wiesel O, Coppolino A, Giannopoulos AA, Mentzer S, Jaklitsch M, Hunsaker A, Mitsouras D. 3-Dimensional Printed Models in Pre-Operative Planning for Superior Sulcus Tumor Surgeries: Utility and Reproducibility. J Surg Oncol. 2017;in press
  • Mitsouras D, Lee TC, Liacouras P, Ionita CN, Pietilla T, Maier SE, Mulkern RV. 3D Printing of MRI-Visible Phantoms and MR Image-Guided Therapy Simulation. Magn Reson Med. 2017; 77(2):613-22
  • Cai T, Giannopoulos A, Sheng Y, Ripley BA, Kelil T, Kumamaru KK, Rybicki FJ, Mitsouras D. Natural Language Processing Technologies in Radiology Research and Clinical Practice. RadioGraphics. 2016;36(1):179-91
  • Giannopoulos A, Mitsouras D, Yoo S-J, Liu P, Chatzisisis YS, Rybicki FJ. Applications of 3D Printing in Cardiovascular Diseases. Nature Reviews Cardiology. 2016;13(12):701-18
  • Giannopoulos A, Steigner ML, George E, Barile M, Hunsaker A, Rybicki FJ, Mitsouras D. Cardiothoracic Applications of 3D Printing. J Thorac Imaging 2016;31(5):253-272
  • Giannopoulos AA, Chatzisisis YS, Maurovich-Horvat P, Antoniadis AP, Hoffmann U, Steigner ML, Rybicki FJ, Mitsouras D, Quantifying the Effect of Side Branches in Endothelial Shear Stress Estimates. Atherosclerosis. 2016;251:213-8
  • George E, Giannopoulos AA, Agayev A, Rohatgi S, Imanzadeh A, Antoniadis AP, Kumamru KK, Chatzisis YS, Dunne R, Steigner ML, Hanley M, Graveraux EC, Rybicki FJ, Mitsouras D. Contrast Inhomogeneity in CT Angiography of the Abdominal Aortic Aneurysm. J Cardiovasc Comput Tomogr. 2015; 2016;10(2):179-83
  • Mitsouras D, Liacouras P, Imanzadeh A, Giannopoulos A, Cai T, Kumamaru KK, George E, Wake N, Caterson EJ, Pomahac B, Ho VB, Grant GT, Rybicki FJ. Medical 3D Printing for the Radiologist. RadioGraphics. 2015;35(7):1965-1988

Fields of Interest

  • Biomedical 3D Printing
  • Cardiovascular imaging
  • Biochemistry
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