Career Opportunities

Description:

Position available: Graduate (MS.c./Ph.D.) student position

Description of the position: Our research focuses on delineating molecular mechanisms that regulate neural stem cell reprograming and differentiation, with the ultimate goal of defining ways to recruit the stem cells that are resident in the brains or are derived from non-neuronal cells, and to thereby potentially promote neural repair. We are currently using stroke, Alzheimer’s disease, multiple sclerosis and autism as brain disease models to explore underlying molecular mechanisms. A variety of molecular, cellular, biochemical and behavioral techniques are used in the laboratory, including transgenic mouse models, in vivo neurodegenerative disease model, primary cell culture, co-IP and ChIP, and single cell RNA-seq approaches and etc.

Requirements:

Eligibility Requirements:

• Experience in Molecular Biology (cloning, mutagenesis, PCR), Cell Biology (cell line or primary cell culture, immunohistochemistry and immunocytochemistry) or in vivo animal model study.
• Excellence at the academic level and in research
• Excellent written and oral communication skills

Deadline: Until the position is filled.
 

To apply:

Individuals who are interested in the position should submit curriculum vitae, a copy of official transcripts, statement of research interest and names of three references to:

jiwang@ohri.ca

Dr. Jing Wang, Ph.D.
Senior Scientist,
Sprott Centre for Stem Cell Research,
Ottawa Hospital Research Institute
Associate Professor, 
Department of Cellular & Molecular Medicine
University of Ottawa
Ottawa Hospital, 501 Smyth Rd, Box 411
Ottawa, ON K1H 8L6 CANADA

We thank all applicants for their interest. However, only those invited for an interview will be contacted

Description:

A postdoctoral fellow position is available in the laboratory of Dr. Nongnuj Tanphaichitr, Ottawa Hospital Research Institute (OHRI), to carry out a new research project. In this study, the candidate will develop dosage formulation (delivery system) of antimicrobial peptides (AMPs) to be administered intravaginally. We will focus on the cathelicidin AMP, LL-37, and its derived peptide, 17BIPHE2, which possess both spermicidal and microbicidal activity (Kiattiburut et al., Human Reprod 2018, 33:2175-2183). As Multipurpose Prevention Technology (MPT) agents, these AMPs will provide women with empowerment to protect themselves against unwanted pregnancies and sexually transmitted infections. This study is funded by Canadian Institutes of Health Research (CIHR) and is being carried out in both mouse (in vitro and in vivo) and human (in vitro and ex vivo) systems.

Requirements:

Candidates must have a Ph.D. in biochemistry, cell biology/physiology or related biomedical fields with ability to communicate well at both oral and written levels. Knowledge and lab experience in the female reproductive physiology, sperm biology, and hydrogel and/or nanoparticles-based drug delivery to the vagina will give priorities in the recruitment. Self-motivation to progress in his/her career as an independent investigator will also be favorably considered.

Salary:

Salary and benefits will be commensurate with the candidate’s experience, following the guideline of OHRI. The term of employment can be up to 4 years. OHRI is one of the foremost Canadian hospital-based research institutes with investigators performing research focusing on answering important health questions and translating their findings into benefits for mankind. A sizable group of researchers in the field of reproductive biology are members of OHRI and also other academic institutes in Ottawa.

To apply:

Please send your CV with description of research experience and names of three references to ntanphaichitr@ohri.ca

General Information:

An MSc position is open in the Tóth lab to conduct structure-function studies on a newly discovered cellular organelle (Anastasia et al. Cell Reports, 2021). The candidate will learn to use state-of-the-art imaging methodologies such as electron tomography to reconstruct the various compartments of the cell in 3D. In addition, they will learn how to design, test, and analyze quantitative electron microscopy data and present them to both scientific and external audiences. Through this research program, the candidate will learn to recognize, evaluate, and solve any complex problem using the scientific method. The student will be part of a highly dynamic and collaborative project.

Please, send your CV to ktoth@uottawa.ca

General Information:

Postdoctoral positions are available in the laboratory of Dr. Xiaohui Zha at Ottawa Hospital Research Institute/University of Ottawa*, Canada (http://www.ohri.ca/profile/Zha).

Project Description:

The project is to study the mechanisms by which cholesterol regulates macrophage inflammation, a key event in atherosclerosis. Cholesterol, a major component of the plasma membrane in mammalian cells, predominantly regulates membrane physical properties. Most likely through its modulation of cellular membranes, cholesterol impacts numerous signal transduction pathways and cellular processes.  Particularly, cholesterol levels in macrophages determine the nature of the inflammation response, for example, pro-inflammatory response (M1), anti-inflammatory (M2) or anything in between. The mechanism is largely unknown.  In recent years, it is increasingly apparent that macrophages can respond to environmental cues to establish an epigenetically “poised” state.  This allows macrophages to rapidly launch a large-scale gene expression program upon stimulation (i.e. LPS). The project will use biochemistry and genomic techniques, such as RNA-seq and ChIP-seq, to understand how cholesterol establishes epigenetically “poised” states in the genome of the macrophages to regulate gene expression for inflammatory responses.

Basic Requirements:

Candidates should be a fresh PhD (less than two years since graduation) in physical science or biological science with good publication record.  Knowledge/experience in genomic system biology is a plus, but not necessary.  If interested, please send curriculum vitae and brief statement of research interest to xzha@ohri.ca .

Contact info:

Xiaohui Zha, Senior Scientist
Chronic Disease Program
Ottawa Hospital Research Institute
501 Smyth Road, Ottawa, ON K1H 8L6
 

*The Ottawa Hospital Research Institute is the research arm of The Ottawa Hospital and an affiliated institute of the University of Ottawa. With more than 1,700 scientists, clinician investigators, trainees and staff, and total revenues of more than $100 million, it is one of the foremost Canadian hospital-based research institutes. Researcher are investigating virtually every major disease and condition, with a focus on answering important health questions and translating our findings into benefits for patients and society.