Research Scientist, Toxicology Research Division, Food Directorate, and Cross-Appointed Member, Associate Professor
Room: Health Canada, Ottawa
Office: (613) 957-0990
Fax: (613) 941-6959
Work E-mail: Gerard.Cooke@hc-sc.gc.ca
Research - Major activities
Many environmental chemicals that contaminate human foodstuffs and natural chemicals occurring in food that possess hormonal activity, are considered as possible endocrine disrupters with reproductive implications for human development and fertility. Investigations use in vivo and in vitro approaches to examine the mechanisms of toxicity of these chemicals.
2003 - 2006 NSERC (PI D. Cyr) A novel pharmacokinetic-gene expression model model for toxicological risk assessment of endocrine disrupting chemicals. $183,000
2004 - 2004 ISC (with D. Forsyth) Speciation of organotins in whole fetuses, fetal tissues and milk following daily oral administration of tributyltin chloride to pregnant and lactating rat dams. $14, 500
Schrader T.J.; Cooke G.M. Effect of aroclors and individual PCB congeners on activation of the human androgen receptor in vitro. Reproductive Toxicology 2003 17: 15-23
McVey M; Cooke G.M. (2003) Inhibition of rat testis microsomal 3ß-hydroxysteroid dehydrogenase activity in vitro by tributyltin. J. Seroid Biochem. Mol. Biol. 86; 99-105
Adeeko, A.; Li, D.; Forsyth DS; Casey V; Cooke, G.M.; Barthelemy J; Cyr DG; Trasler, J.M.; Hales, B.F.; Robaire, B. (2003) Effects of in utero exposure to tributyltin chloride in the rat on pregnancy outcome. Toxicological Sciences 74; 407-415
Adeeko, A.; Li, D.; Doucet, J.; Cooke, G.M.; Trasler, J.M.; Hales, B.F.; Robaire, B. (2003) Gestational Exposure to Persistent Organic Pollutants: Maternal Liver Residues, Pregnancy Outcome, and Effects on Hepatic Gene Expression Profiles in the Dam and Fetus. Toxicological Sciences 72: 242-252
Wade, M.G., Lee, Alice., McMahon, A., Cooke, G.M., Curran, I. (2003) The influence of dietary isoflavone on the uterotrophic response in juvenile rats. Food and Chemical Toxicology 41: 1517-1525.
Cooke, G.M.; Tryphonas, H.; Pulido, O.; Caldwell, D.; Bondy, G.S.; Forsyth, D. (2004) Oral (gavage), in utero and post-natal exposure of Sprague-Dawley rats to low doses of tributyltin chloride. Part 1: Toxicology, histopathology and clinical chemistry. Food and Chemical Toxicology 42: 217-226.
Tryphonas, H.; Cooke, G.M.; Caldwell, D.; Bondy, G.S.; Parenteau, M.; Hayward, S., Pulido, O. (2004): Oral (gavage), in utero and post-natal exposure of Sprague-Dawley rats to low doses of tributyltin chloride. Part II: Effects on the immune system. Food and Chemical Toxicology 42: 227-241.