Andrée-Anne Ledoux

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Andrée-Anne Ledoux
Assistant Professor, Scientist, CHEO Research Institute

Office: 613-737-7600 ext. 4104
Work E-mail: aledoux@uottawa.ca
Work E-mail: aledoux@cheo.on.ca

Dr. Andrée-Anne Ledoux

Biography

Dr. Ledoux, earned her PhD studies in Experimental Psychology at the University of Ottawa, specializing in behavioural neuroscience and neuropsychology. She was the recipient of the Frederick Banting and Charles Best Canada Graduate Scholarships for her master and PhD studies. Her research interest includes the development of novel approaches for the assessment, treatment and understanding of concussion, and mental health. She has published in the areas of neuroimaging and schizophrenia, virtual reality paradigms, and concussion. Currently, she is investigating concussion and early return to activity, resiliency, and mental health in concussed youth.
 

Research Interests:

Andrée-Anne Ledoux and her team is interested in developing and testing management protocols that target neuronal repair in the hopes of reducing the risk of persistent post-concussive symptoms, reducing the recovery period, and promoting resiliency and neural protection in pediatric concussion. She is interested in identifying recovery neural correlates that can be used as recovery biomarkers in concussion, and investigating how behavioural treatments can modify these biomarkers. She is currently investigating the acute and subacute clinical, neuropsychological and neurophysiological recovery processes of two different behavioural management protocols: early return to physical activity and mindfulness-based intervention with MRI.  Given the extensive brain maturation and significant functional development that occurs throughout childhood in addition to the sex differences that exist throughout development, she also explores age and sex-based differences in all of her concussion related studies.  Together with multidisciplinary approach, cutting edge techniques and national/international collaborations she hopes to reduce the impact of concussion in children and adolescents and their family.   


Current Projects:

  1. Mulitcentre randomized clinical trial pediatric concussion assessment of rest and exertion (PedCARE).
  2. Pediatric concussion assessment of rest and exertion with MRI (PedCARE+MRI).
  3. Mindfulness-based intervention for pediatric concussion with MRI (MBI-4-mTBI+MRI)
  4. Pediatric concussion and subsequent mental health disorders, self-harm and suicide.

 

Experimental Approaches:

Pediatric human research, magnetic resonance imaging (MRI), arterial spin labeling, diffusion tensor imaging, resting state and task based functional MRI, spectroscopy, neuropsychological assessments, epidemiology, translational research, evidence to practice research.
 

Selected Publications:

  • Gravel, J., Ledoux, A-A., Tank, K., Yeates, K.O., Craig, W., Osmond, M., Boutis, K., Burns, E., Shangha, G., Dubrovsky, A.S., Beer, D., Zemek, R. (2019). Early vs. Delayed ED Presentation Following mTBI and the Risk of Symptom Persistence in Children. Pp.1-10. (Accepted to Emergency Medicine Journal).
  • Ledoux, A.A., Tang, K., Yeates, K.O., Pusic, M., Boutis, K., Craig, W., Gravel, J.,  Freedman, S.B., Gagnon, I., Gioia, G., Osmond, M.H. and Zemek, R. for the Pediatric Emergency Research Canada (PERC) Concussion Team (2019). Natural Progression of Symptom Change and Recovery from Concussion in a Pediatric PopulationJAMA Pediatrics, 173(1):e183820.  10.1001/jamapediatrics.2018.3820
  • Walsh, J., Barnes, J.D., Cameron, J.D., Goldfield, G.S., Chaput, J-P, Gunnell, K.E., Ledoux, A-A, Zemek, R, Tremblay, M.S. (2018). Associations between 24-hour movement behaviors and global cognition in American children. Lancet Child & Adolescent Health's, 2(11): 783-791. DOI: https://doi.org/10.1016/S2352-4642(18)30278-5 Pediatric Exercise Science chose this study as the most significant and exciting of the year 2018 and was feature in the Expert’s Choice commentary https://doi.org/10.1123/pes.2019-0010.
  • Bresee, N., Aglipay, M., Dubrovsky, A.S., Ledoux, A-A., Momoli, F., Gravel, J., Freedman, S., Barlow, K., Richer, L., Barrowman, N., and Zemek, R. (2018) Association between metoclopramide treatment in the ED and post-concussion headache, Emergency Medecine, 36(12): 2225-2231. DOI: 10.1016/j.ajem.2018.04.007
  • Ledoux, A-A., Barrowman, N., Boutis, K., Davis, A., Reid, S., Sangha, G., Farion, K.J., Belanger, K., Tremblay, M.S., Yeates, K.O., DeMatteo, C., Reed, N., Zemek, R. (2017). Multicentre, Randomized Clinical Trial of Pediatric Concussion Assessment of Rest and Exertion (PedCARE): A Study to Determine When to Resume Physical Activities Following Concussion in Children,  British Journal of Sport Medecine, 53:195. DOI:
  • Grool, A., Aglipay, M., Momoli, F., Meehan III, W., Freedman, S., Yeates, K.O., Gravel, J., Gagnon, I., Bouttis, K., Meeuwisse, W., Barrowman, N., Ledoux, A-A., Osmond, M.H. & Zemek, R. (2016).  Association Between Early Participation in Physical Activity Following Acute Concussion and Persistent Post-Concussive Symptoms in Children and Adolescents, JAMA, 316(23): 2504-2514. DOI:
  • Ledoux, A-A., Boyer, P., Phillips, J.L., Labelle, A., Smith, A., Bohbot, V.D. (2014) Structural hippocampal anomalies in a schizophrenia population correlate with navigation performance on a wayfinding task. Frontiers Behavioral Neuroscience 8(88): 1-11.
  • Ledoux, A-A., Phillips, J.L., Labelle, A., Smith, A., Bohbot, V.D., Boyer, P. (2013) Decreased fMRI activity in the hippocampus of patients with schizophrenia tested on a wayfinding task in a virtual town. Psychiatry Research: Neuroimaging, 221(1), 47-56. 

 

Fields of Interest

  • Concussion
  • Biomarkers of recovery after concussion
  • Magnetic resonance imaging
  • Perfusion
  • Default Mode Network
  • Mental health
  • Neurocongtive disorders in concussion and mental health
  • Schizophrenia
  • Pediatrics
  • Evidence to practice medicine
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