William Staines

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William Staines
Professor | Member of the Faculty Council for the Faculty of Medicine

BSc Biochemistry, University of Alberta
PhD Neurological Sciences, University of British Columbia
Postdoctoral Fellow, Histology, Karolinska Institute, Sweden
Postdoctoral Fellow, Physiology, University of Manitoba

Room: RGN 3220C
Office: 613-562-5800 ext. 8188
Work E-mail: wstaines@uottawa.ca

Dr. William Staines

Biography

Overview of Interests

Past work in Dr. Staines’ lab has involved the study of normal function-pathophysiology of brain regions associated with movement disorders. More recently he has turned his attention to the study of Rett Syndrome. The biological basis of Rett Syndrome is related to the inability of neurons in a network to properly modify their communication in response to environmental input. In most cases of Rett Syndrome, disruption of a single gene (mecp2) is responsible for these complex downstream consequences. One of the downstream consequences of greatest current interest is in the suppression of levels of brain derived neurotrophic factor. Tissue culture experiments on both brain and gut neurons will evaluate means of reversing this blunted neurotrophic factor response and to normalize neuronal network function.

Research Achievements

Dr. Staines has over 100 research publications, including 16 with more than 100 citations. 

Grant Support

Dr. Staines’ research is presently funded by the CHEO Foundation (Jessica Carr Fund for Rett Syndrome research).

Fields of Interest

  • Neurological Disease
  • Digestive System
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