The Faculty of Medicine, with support from affiliated hospital-based research institutes and the University of Ottawa, has successfully developed a series of cutting-edge core facilities which bring together state-of-the-art equipment, instrumentation, methodologies and expertise crucial to the success of basic and clinical research activities. These facilities are accessible to all researchers across the University of Ottawa as well as to outside communities on a fee-for-service basis. To date, 11 cores have been established. For each facility, director and user committees have been appointed to ensure accountability and optimal use for the continued commitment and success of our expanding core facilities.