Dr. Julian Little* PhD MA BA


Dr. Julian Little* PhD MA BA

Room: 600 Peter Morand (Alta Vista), Room 207G
Office: 613-562-5800 ext. 8061
Work E-mail: jlittle@uottawa.ca

Dr. Julian Little


Julian Little has been a Professor in the School of Epidemiology and Public Health (Director 2006-2016) at the University of Ottawa since 2004. He currently holds a Distinguished Research Chair in Chronic Disease Epidemiology and Control, is a Visiting Professor at Shanghai Jiao Tong University School of Medicine (2017-2020) and is an IUSS-Ferrara 1391 Copernicus Visiting Scientist, University of Ferrara (2018-2019). His PhD, from Aberdeen University, was on problems of ascertainment of congenital anomalies. Subsequently, he worked for the EUROCAT Central Registry in Brussels (Belgium), as a lecturer in epidemiology in Nottingham University, as an epidemiologist in the International Agency for Research on Cancer in Lyon, and as Professor of Epidemiology at Aberdeen University, during which he spent a sabbatical year at the Office of Genomics and Disease Prevention, CDC, Atlanta. He is currently involved in, or developing, research on:

[1] Congenital anomalies, specifically (a) the effects of B-group vitamins on congenital anomalies and other chronic diseases; (b) completeness of ascertainment; (c) maternal gene-environment effects on orofacial clefts and congenital heart disease; and (d) prenatal screening;

[2] Psychosis and affective psychosis, specifically (a) within-week variation in in-hospital outcomes for patients with psychosis and affective psychosis; (b) trajectories of hospitalizations; and (c) the development and testing of a multifaceted intervention including physical activity aimed at improving physical health and quality of life;

[3] Knowledge synthesis and public health, co-PI of the Ottawa Evidence Review and Synthesis Centre, funded by the Public Health Agency of Canada to support development of preventive healthcare guidelines by the Canadian Task Force on Preventive Health Care. There are ongoing projects on screening for cancer, depression and hypertension, tobacco cessation and interventions to reduce potentially inappropriate prescribing;

[4] Head & Neck Conditions, specifically (a) oral and genital HPV infection in female partners of men with HPV-related head and neck cancer; (b) the frequency of, and risk factors for, persistent oral oncogenic HPV infection; (c) the outcomes of different managements for sensorineural hearing loss; (d) use of remote audio-verbal therapy after cochlear implant; (e) analysis of audiometric tests using an iPad App ; and (f) risk of cataract in workers in the nuclear industry.

There are at present opportunities for student projects on (1) prenatal screening (developing an instrument analogous to the quality adjusted life year (QALY) suitable for use with pregnant women); incidental findings from non-invasive prenatal screening using genomic sequencing of circulating fetal DNA); (2) application of capture-recapture methods to investigate completeness of ascertainment of congenital anomalies); (3) patterns of anomalies associated with neural tube defects in Europe; (4) psychosis and affective psychosis; (5) analysis of audiometric tests; and (6) risk of cataract in workers in the nuclear industry.

Fields of Interest

  • Epidemiology and Prevention of Congenital Anomalies
  • Psychosis and affective psychosis
  • Cancer Epidemiology and Prevention
  • Molecular and Human Genome Epidemiology
  • Evidence synthesis related to public health
  • Health services research
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