Dr. Julian Little* PhD MA BA

E-Card

Dr. Julian Little* PhD MA BA
Professor

Canada Research Chair in Human Genome Epidemiology

Room: 600 Peter Morand (Alta Vista), Room 207G
Office: (613) 562-5800 ext. 8061
Work E-mail: jlittle@uottawa.ca

Dr. Julian Little

Biography

Dr. Little’s expertise and experience lies in epidemiology in multi-disciplinary contexts, including maternal and child health, cancer epidemiology and prevention, nutrition, public health genetics and evidence synthesis (he is Secretary of the Society for Research Synthesis Methodology).

He has been a Professor in the School of Epidemiology and Public Health (Director 2006-2016) at the University of Ottawa since 2004, and  holds a Canada Research Chair in Human Genome Epidemiology. His PhD, from Aberdeen University, was on problems of ascertainment of congenital anomalies. Subsequently, he worked for the EUROCAT Central Registry in Brussels (Belgium), as a lecturer in epidemiology in Nottingham University, as an epidemiologist in the International Agency for Research on Cancer in Lyon, and as Professor of Epidemiology at Aberdeen University, during which he spent a sabbatical year (2002-3) at the Office of Genomics and Disease Prevention, CDC, Atlanta. He is also a Visiting Professor in the Shanghai Jiao Tong University School of Medicine (China) and the Department of Biomedical Sciences and Specialist Surgery, University of Ferrara (Italy).

Selected publications

  • Khoury MJ, Bedrosian SR, Gwinn M, Higgins JPT, Ioannidis JPA, Little J. (Editors). Human Genome Epidemiology (Second Edition); Building the evidence for using genetic information to improve health and prevent disease. New York, Oxford University Press, 2010.
  • Khan MFJ, Little J, Mossey PA, Steegers-Theunissen RPM, Autelitano L, Lombardo I, Bassi Andreassi R, Rubini M. Evaluating LINE-1 methylation in cleft lip tissues and its association with early pregnancy exposures. Epigenomics 2018; 10(1): 105-113.
  • Langlois S, Johnson J, Audibert F, Gekas J, Forest JC, Caron A, Harrington K, Pastuck M, Meddour H, Tétu A, Little J, Rousseau F. Comparison of first tier cell-free DNA screening for common aneuploidies with conventional publically funded screening. Prenatal Diagnosis 2017; 37(12): 1238-4.
  • Mossey PA, Little J, Steegers-Theunissen R, Molloy A, Peterlin B, Shaw WC, Johnson C, FitzPatrick DR, Franceschelli P, Rubini M. Genetic interactions in non-syndromic orofacial clefts in Europe – EUROCRAN study.  Cleft Palate-Craniofacial Journal. 2017;54(6):623-630.
  • Liu H, Zhou G, Chen Q, Ouyang F, Little J, Zhang J, Chen D. Impact of dehydroepiandrosterone sulfate on newborn leukocyte telomere length. Sci Rep. 2017;7:42160.
  • Bhardwaj K, Locke T, Biringer A, Booth A, Darling EK, Dougan S, Harrison J, Hill S, Johnson A, Makin S, Potter B, Lacaze-Masmonteil T, Little J. Newborn bilirubin screening for preventing severe hyperbilirubinemia and bilirubin encephalopathy: a rapid review. Curr Pediatr Rev. 2017; 13(1): 67-90.
  • Wilson K, Hawken S, Murphy M, Atkinson K, Potter B, Sprague A, Walker M, Chakraborty P, Little J. Postnatal prediction of gestational age using newborn fetal hemoglobin levels. EBioMedicine. 2017 Feb;15:203-209.
  • Bennett DA, Landry D, Little J, Minelli C. Systematic review of statistical approaches to quantify, or correct for, measurement error in a continuous exposure in nutritional epidemiology. BMC Medical Research Methodology 2017; 17(1): 146.
  • Leo PJ, Madeleine MM, Wang S, Schwartz SM, Newell F, Kymmer U, Hemminki K, Hallmans G, Tiews S, Steinberg W, Rader JS, Castro F, Safaeian M, Franco EL, Coutlée F, Ohlsson C, Cortes A, Marshall M, Mukhopadhyay P, Cremin K,. Johnson LG, Garland S, Tarbrizi S, Wentzensen N, Sitas F, Little J, Cruickshank M, Frazer IH, Hildesheim A, Brown MA.  Defining the genetic susceptibility to cervical neoplasia – a genome-wide association study. PLOS Genetics 2017; 13(8): e1006866.
  • Little J, Barakat-Haddad C, Martino R, Pringsheim T, Tremlett H, McKay K, Van Lieshout P, Walsh SJ, Gomes J , Krewski D. Genetic variation associated with the occurrence and progression of neurological disorders. Neurotoxicology. 2017; 61: 243-264.
  • Foster WG, Evans JA, Little J, Arbour L, Moore A, Sauve R, León JA, Luo W. Human exposure to environmental contaminants and congenital anomalies: a critical review. Critical Reviews in Toxicology. 2017 Jan;47(1):59-84.
  • Montazeri Z, Nyiraneza C, El-Katerji H, Little J. Waterpipe smoking and cancer: systematic review and meta-analysis. Tob Control. 2017 Jan;26(1):92-97.
  • Zehbe I, Jackson R, Wood B, Weaver B, Escott N, Severini A, Krajden M, Bishop L, Morrisseau K, Ogilvie G, Burchell AN, Little J. A community-randomized controlled trial embedded in the Anishinaabek Cervical Cancer Screening Study: human papillomavirus self-sampling versus Papanicolaou cytology. BMJ Open. 2016 Oct 8;6(10):e011754.
  • Liu S, Joseph KS, Luo W, Leon JA, Lisonkova S, Van den Hof M, Evans J, Lim K, Little J, Sauve R, Kramer MS; Canadian Perinatal Surveillance System (Public Health Agency of Canada). Effect of folic acid food fortification in Canada on congenital heart disease subtypes. Circulation. 2016 Aug 30;134(9):647-55.
  • Wood B, Rogers Van Katwyk S, El-Khatib Z, McFaul S, Taljaard M, Wright E, Graham ID, Little J. Eliciting women's cervical screening preferences: A mixed methods systematic review protocol. Systematic Reviews. 2016 Aug 11;5(1):136.
  • Tagliabue E, Gandini S, García-Borrón JC, Maisonneuve P, Newton-Bishop J, Polsky D, Lazovich D, Kumar R, Ghiorzo P, Ferrucci L, Gruis NA, Puig S, Kanetsky PA, Motokawa T, Ribas G, Landi MT, Fargnoli MC, Wong TH, Stratigos A, Helsing P, Guida G, Autier P, Han J, Little J, Sera F, Raimondi S; M-SKIP Study group. Association of Melanocortin-1 Receptor Variants with Pigmentary Traits in Humans: A Pooled Analysis from the M-Skip Project. J Invest Dermatol. 2016 Sep;136(9):1914-7.1.    
  • Choi BC, Li L, Lu Y, Zhang LR, Zhu Y, Pak AW, Chen Y, Little J. Bridging the gap between science and policy: an international survey of scientists and policy makers in China and Canada. Implement Sci. 2016 Feb 6;11:16.
  • Montazeri Z, Theodoratou E, Nyiraneza C, Timofeeva M, Chen W, Svinti V, Sivakumaran S, Gresham G, Cubitt L, Carvajal-Carmona L, Bertagnolli MM, Zauber AG, Tomlinson I, Farrington SM, Dunlop MG, Campbell H, Little J. Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas. Int J Epidemiol. 2016 Feb;45(1):186-205.
  • Little J, Wilson BJ, Carter R, Walker K, Santaguida P, Tomiak E, Beyene J, Usman Ali M, Raina P. Multi-Gene Panels in Prostate Cancer Risk Assessment. A Systematic Review. Genet Med. 2016; 18(6):535-44.
  • Sharp L, Cotton S, Cruickshank M, Gray N, Smart L, Whynes D, Little J; TOMBOLA Group. Impact of post-colposcopy management on women’s long-term worries: results from the UK population-based TOMBOLA trial. J Fam Plann Reprod Health Care. 2016 Jan;42(1):43-51.
  • Potter BK, Khangura SD, Tingley K, Chakraborty P, Little J; in collaboration with the Canadian Inherited Metabolic Diseases Research Network. Translating rare disease therapies into improved care for patients and families: what are the right outcomes, designs and engagement approaches in health systems research? Genet Med. 2015 Feb;18(2):117-23.
  • Golfam M, Beall R, Brehaut J, Saeed S, Relton C, Ashbury FD, Little J. Comparing alternative design options for chronic disease prevention interventions. Eur J Clin Invest. 2015 Jan;45(1):87-99. doi: 10.1111/eci.12371.
  • Iglesias AI, Mihaescu R, Ioannidis JP, Khoury MJ, Little J, van Duijn CM, Janssens AC. Scientific reporting is suboptimal for aspects that characterize genetic risk prediction studies: a review of published articles based on the Genetic RIsk Prediction Studies statement.  J Clin Epidemiol., 2014 May;67(5):487-99.
  • Tasca GA, Lelievre JY, Qiu Q, Ritchie K, Little J, Trineer A, Barber A, Chyurlia L, Bissada H, Gruslin A.  Characterization of IGF-II isoforms in binge eating disorder and its group psychological treatment. PLoS One. 2013 Dec 30;8(12):e83019.
  • Nicholls SG, Wilson BJ, Craigie SM, Etchegary H, Castle D, Carroll JC, Potter BK, Lemyre L, Little J. Public attitudes towards genomic risk profiling as a component of routine population screening. Genome. 2013 Oct;56(10):626-33.
  • Hasanaj Q, Wilson BJ, Little J, Montazeri Z, Carroll JC on behalf of the CIHR Emerging Team in Genomics in Screening.  Family History: impact on coronary heart disease risk assessment beyond guideline-defined factors.  Public Health Genomics. 2013;16(5):208-14.
  • Botto LD, Flood T, Little J, Fluchel MN, Krikov S, Feldkamp ML, Wu Y, Goedken R, Puzhankara S, Romitti PA.  Cancer Risk in Children and Adolescents with Birth Defects: A Population-Based Cohort Study. PLoS ONE 2013; 8(7): e69077.
  • Butali A, Little J, Chevrier C, Cordier S, Steegers-Theunissen R, Jugessur A, Oladugba B, Mossey PA. Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis. Birth Defects Res A Clin Mol Teratol. 2013 Aug;97(8):509-14.
  • Aljasir B, Ioannidis JP, Yurkiewich A, Moher D, Higgins JP, Arora P, Little J. Assessment of systematic effects of methodological characteristics on candidate genetic associations. Hum Genet. 2013 Feb;132(2):167-78.
  • Theodoratou E, Montazeri Z, Hawken S, Allum G, Gong J, Tait V, Kirac I, Tazari M, Farrington SM, Demarsh A, Zgaga L, Landry D, Benson HE, Read SH, Rudan I, Tenesa A, Dunlop MG, Campbell H, Little J. Systematic meta-analyses and field synopsis of genetic association studies in colorectal cancer. J Natl Cancer Inst., 2012 Oct 3;104(19):1433-57.
  • Benamouzig R, Uzzan B, Deyra J, Martin A, Girard B, Little J, Chaussade S; Association pour la Prévention par l’Aspirine du Cancer Colorectal Study Group (APACC). Prevention by daily soluble aspirin of colorectal adenoma recurrence: 4-year results of the APACC randomised trial. Gut., 2012 Feb;61(2):255-61.
  • Dennis J, Hawken S, Krewski D, Birkett N, Gheorghe M, Frei J, McKeown-Eyssen G, Little J. Bias in the case-only design applied to studies of gene-environment and gene-gene interaction; a systematic review and meta-analysis. IJE, 2011; 40(5):1329-41.
  • Fortier I, Doiron D, Little J, Ferretti V, L’Heureux F, Stolk RP, Knoppers BM, Hudson T, Burton P. Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies. International Journal of Epidemiology, 2011; 40: 1314-1328.
  • Janssens AC, Ioannidis JP, van Duijn CM, Little J, Khoury MJ; for the GRIPS Group. Strengthening the reporting of Genetic RIsk Prediction Studies: The GRIPS Statement. J Clin Epidemiol. 2011; 64:843-7.
  • Janssens AC, Ioannidis JP, Bedrosian S, Boffetta P, Dolan SM, Dowling N, Fortier I, Freedman AN, Grimshaw JM, Gulcher J, Gwinn M, Hlatky MA, Janes H, Kraft P, Melillo S, O'Donnell CJ, Pencina MJ, Ransohoff D, Schully SD, Seminara D, Winn DM, Wright CF, van Duijn CM, Little J, Khoury MJ. Strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS): explanation and elaboration. J Clin Epidemiol. 2011; 64:e1-e22.
  • Mastroiacovo P, Maraschini A, Leoncini E, Mossey P, Bower C, Castilla EE, Feldkamp ML, Halliday J, Little J; for the IPDTOC Working Group. Prevalence at Birth of Cleft Lip With or Without Cleft Palate: Data From the International Perinatal Database of Typical Oral Clefts (IPDTOC). Cleft Palate Craniofac J., 2011;48(1):66-81.
  •  Wolfson M, Wallace SE, Masca N, Rowe G, Sheehan NA, Ferretti V, LaFlamme P, Tobin MD, Macleod J, Little J, Fortier I, Knoppers BM, Burton PR.  DataSHIELD: resolving a conflict in contemporary bioscience - performing a pooled analysis of individual-level data without sharing the data. International Journal of Epidemiology, 2010; 39:1372-82.
  • Hawken SJ, Greenwood CMT, Hudson TJ, Kustra R, McLaughlin J, Yang Q, Zanke BW, Little J. The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. Human Genetics, 2010; 128(1):89-101.
  • Langlois K, Greene-Finestone L, Little J, Hidiroglou N, Whiting S.  Vitamin D status of Canadians as measured in the 2007 to 2009 Canadian Health Measures Survey.   (Statistics Canada, Catalogue no. 82-003-XPE.) Health Reports, 2010; 21(1):47-55.
  • TOMBOLA Group  (Writing and analysis group: Little J, Sharp L, Cotton S, Cruickshank M, Duncan I, Harrild K, Jenkins D, Smart L, Waugh N, Cochran C, Gray N, Hammond R, Neal K, Thornton A, Woolley C).  Cytological surveillance compared with immediate referral for colposcopy in the management of women with low-grade cervical abnormalities: multicentre randomised controlled trial. BMJ, 2009; 339: DOI 10:1136/bmj.b2546.
  • Little J, Higgins J, Ioannidis JPA, Moher D, Gagnon F, von Elm E, Khoury MJ, Cohen B, Davey-Smith G, Grimshaw J, Scheet P, Gwinn M, Williamson RE, Zou GY, Hutchings K, Johnson CY, Tait V, Wiens M, Golding J, van Duijn C, McLaughlin J, Paterson A, Vogan KJ, Wells GA, Fortier I, Freedman M, Zecevic M, King R, Infante-Rivard C, Stewart A, Birkett N.  STrengthening the REporting of Genetic Association Studies (STREGA) – an extension of the STROBE Statement.  Annals of Internal Medicine, 2009; 150(3):206-215.
  • Lowry RB, Johnson CY, Gagnon F, Little J.  Segregation analysis of cleft lip with or without cleft palate in the First Nations (Amerindians) people of British Columbia & review of isolated cleft palate etiologies.  Birth Defects Research Part A: Clinical and Molecular Teratology, 2009; 85(6): 568-573.
  • Terry MB, Howe G, Pogoda JM, Zhang FF, Ahlbom A, Choi W, Giles GG, Little J, Lubin F, Menegoz F, Ryan P, Schlehofer B, Preston-Martin S.  An international case-control study of adult diet and brain tumor risk: a histology-specific analysis by food group.  Annals of Epidemiology, 2009;19:161–171.
  • Burton PR, Hansell AL, Fortier I, Manolio TA, Khoury MJ, Little J, Elliott P.  Size matters: just how big is BIG? Quantifying realistic sample size requirements for human genome epidemiology. International Journal of Epidemiology, 2009; 38:263-73.

Fields of Interest

  • Molecular and Human Genome Epidemiology
  • Cancer Epidemiology and Prevention
  • Epidemiology and Prevention of Congenital Anomalies
  • Health services research
  • Mental Health
Back to top