Thesis Defences - Archives

September 2020


  • Studying the Effect of Low Doses of Ionization Radiation on Senescence in Human Lung Fibroblasts.
    Usha Kabilan, MSc in Biochemistry
  • SAP102 Switches the Mechanism of D₁R-Mediated ERK1/2 Activation from a PKA-Independent to PKA-Dependent Pathway
    Bradley Mischuk, MSc in Neuroscience
  • Intraoperative Physiologic Monitoring During Endovascular Revascularization for Atherosclerotic Peripheral Arterial Disease
    Mark Rockley, MSc in Epidemiology
  • Sexually Dimorphic Effects of Prenatal Stress on Physical Growth and Stress-Related Behaviors in Prepubertal Mouse Offspring
    Natasha Osborne, MSc in Neuroscience
  • High-Throughput Screening of Kinase siRNAs and Small Molecule Compounds Identify Novel Candidates for the Development of Myotonic Dystrophy Type 1 Therapies: A Step Towards Therapeutic Advancements in DM1
    Nafisa Neault, PhD in Cellular and Molecular Medicine
  • Role of Inflammatory Cytokine Signaling in Control of Bacterial Infection
    Pallavi Saxena, MSc in Microbiology and Immunology
  • Heat Shock Factor 1 (HSF1) Modulates Inflammation and Survival Post-Myocardial Infarction
    Supriya Hota, MSc in Cellular and Molecular Medicine
  • The role of sCD127 in IL-7-Mediated T Cell Homeostasis in Vivo
    Nawaf Aloufi, MSc in Microbiology and Immunology
  • Myeloid AMPK in Atherosclerosis: Therapeutic Potential and Associated Mechanisms
    Nicholas Leblond, PhD in Biochemistry
  • Targeting CD155 on Myeloid Derived Suppressor Cells to Prevent Postoperative Immunosuppression in Cancer Patients
    André Martel, MSc in Microbiology and Immunology
  • Effect of Long-Term Exposure to Ambient Fine Particulate Matter (PM2.5) on the Incidence of Type 2 Diabetes Mellitus (T2DM): A Cohort Study in Rural China
    Cindy Yu, MSc in Epidemiology
  • Visual Impairment, Eye Disease and Their Risk of Depression and Cognitive Decline: The Canadian Longitudinal Study on Aging
    Alyssa Grant, MSc in Epidemiology
  • Analysis of the Antigenic Composition and Differential Incorporation of Host Membrane Proteins into Murine Leukemia Virus by Flow Virometry
    Mariam Maltseva, MSc in Microbiology and Immunology
  • The Role of Plasma Gelsolin in Epithelial Ovarian Cancer Chemoresistance
    Meshach Asare-Werehene, PhD in Cellular and Molecular Medicine
  • Inhibition of Hypoxia and EGFR Sensitizes TNBC to Cisplatin and Suppresses Bulk and Cancer Stem Cells
    Sarah McGarry, MSc in Biochemistry
  • Bio-Cellulose Based Composite Protein Delivery System for Spinal Cord Regeneration
    Hesham Ismail, MSc in Neuroscience
  • Impact of Parkinson’s Disease- Linked- Lrrk2 Mutation (Lrrk2G2019S) on the Innate Immune Response During Infection with Listeria Monocytogenes.
    Leila Sam, MSc in Microbiology and Immunology
  • Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota under Antibiotic Treatment
    Alexander Laskey, MSc in Microbiology and Immunology

August 2020


  • Investigating the Role of VGF and Its Associated Neuropeptides in Post-Stroke Recovery and Repair
    Hannah Gillis, MSc in Biochemistry
  • Role of Optineurin in Metabotropic Glutamate Receptor 5-regulated Autophagy
    Caitlyn McLaren, MSc in Cellular and Molecular Medicine
  • Bifluorescent Analysis of ⍺-Synuclein Aggregation In Vivo
    Kianna Mau, MSc in Biochemistry
  • The Effects of BPA and BPS on Skeletal Muscle and Adipose Tissue Metabolism
    Fozia Ahmed, MSc in Biochemistry
  • Modeling Defective Epigenetic Inheritance in Vascular Aging Using Hutchinson-Gilford Progeria Syndrome Vascular Smooth Muscle Cells
    Zhaoyi Chen, PhD in Cellular and Molecular Medicine
  • Sexual Anxiety Among Non-Monogamous Men Who Have Sex with Men: A Phenomenological Study
    Cayden Peixoto, MSc in Epidemiology
  • In Vivo Characterization of Cortical Noradrenergic Activity During Motor Learning Using an Optical Noradrenaline Sensor in Mice
    Nathaniel Jones, MSc in Neuroscience
  • Extracellular Vesicles and the Quest for Molecular Biomarkers for Amyotrophic Lateral Sclerosis
    Charlotte Manser, MSc in Biochemistry
  • Characterization of HIV-1 Proviral Latency Induced Through APOBEC3 Mutagenesis and Reverse Transcriptase Error
    Matthew Greig, MSc in Microbiology and Immunology
  • The Impact of Cerebral Microinfarction on Blood-Brain Barrier Permeability and Behaviour in Mice
    Melissa Filadelfi, PhD in Neuroscience
  • A Redox Chemistry-based Function for Parkinson Disease-linked Parkin Confers Direct, Anti-oxidant Activities in Mammalian Brain
    Daniel El Kodsi, PhD in Neuroscience

July 2020


  • Characterization of the Mutational Signature of Formaldehyde to Elucidate Its Role in Carcinogenesis
    Reena Fabros, MSc in Biochemistry
  • Analysis of Autophagy Induction through ATG16L1 Phosphorylation
    Wensheng Tian, MSc in Cellular and Molecular Medicine
  • Molecular Regulation of Satellite Cell Fate
    Peter Feige, PhD in Cellular and Molecular Medicine
  • Investigation of Novel Genetic Causes of Early Infantile Epileptic Encephalopathies Using Next Generation Sequencing and Zebrafish and Cellular Modelling
    Devon Johnstone, PhD in Biochemistry
  • A Behavioural and Neurophysiological Characterization of a Mouse Model of Perinatal Stroke
    Sarah Zhang, MSc in Neuroscience
  • TGFβ Causes Postoperative Natural Killer Cell Paralysis Through mTOR Inhibition
    Marisa Market, PhD in Microbiology and Immunology
  • Characterization of the Immune Response Induced by Rhabdovirus-Infected Leukemia Cell Vaccines
    Elena Scut, MSc in Biochemistry
  • Bioinformatics for Quantitative, Targeted Lipidomics Discovery
    Justin Chitpin, MSc in Biochemistry
  • Bioenergetic Implications of the AMPKg3 R225W Mutation in Human Muscle
    Nina Hadzimustafic, MSc in Biochemistry
  • ATG14L and ZBTB16: Critical Roles in Aggrephagy in STHdhQ7/Q7 Striatal Neurons
    Vanessa Kissner, MSc in Cellular and Molecular Medicine
  • Wnt/β-Catenin Signalling Inhibits T-Type Calcium Channels in Cardiomyocytes
    Kaya Florczak, MSc in Cellular and Molecular Medicine

June 2020


  • The Risks Associated with Blood Transfusion in Kidney Transplant Patients: A Retrospective Cohort Study Using Routinely Collected Data
    David Massicotte-Azarniouch, MSc in Epidemiology
  • Risk Factors, Mechanisms and Therapeuthic for Right Heart Failure Associated with Pulmonary Hypertension
    Jason Zelt, PhD in Cellular and Molecular Medicine
  • Structure-Function Relationship of the Sterol Transporter ABCG5/G8: Expression, Purification and Enzymatic Characterization of ABCG5/G8 Missense Loss of Function Mutations
    Aiman Zein, MSc in Biochemistry
  • TBX5 Mechanism of Action in Skeletal Muscle Cell Proliferation and Differentiation
    Massomeh Sheikh-Hassani, PhD in Biochemistry
  • Distributed Network Meta-Analysis Estimates Results from Individual-Level Analysis Using Ontario Health Administrative Data on Pediatric Inflammatory Bowel Disease Health Services Use: A Population-Based Cohort Study
    Aman Dheri, MSc in Epidemiology
  • Optimizing Protein Characterization using Machine Learning Guided Mass Spectrometry
    Alexander Pelletier, MSc in Biochemistry
  • Nuclear and Molecular Imaging Modalities for Predicting Calcific Aortic Valve Disease Progression in Animal Models
    Gedaliah Farber, MSc in Biochemistry

May 2020


  • MiR-145-5p: its roles in oligodendrocyte differentiation and its contributions to the pathophysiology of demyelinating disease
    Samantha F. Kornfeld, PhD in Cellular and Molecular Medicine
  • Identifying Comorbid Risk Factors of West Nile Neuroinvasive Disease in the Ontario Population, 2002-2012, Using Laboratory and Health Administrative Data
    Jessica Sutinen, MSc in Epidemiology
  • Cell migration is regulated by mitochondria and endoplasmic reticulum morpholog
    Redaet Daniel, MSc in Biochemistry
  • Perioperative allogenic red blood cell transfusion: available guidance and audit of appropriateness in liver resection
    Laura Baker, MSc in Epidemiology
  • The Functional Characterization of PCSK9's Binding Interactions with LDL and the LDL Receptor
    Angela Matyas, MSc in Biochemistry
  • Behaviour theory-based correlates, barriers, and enablers to organ donation registration
    John Bonnell, MSc in Epidemiology
  • Latent Tuberculosis Infection in Iqaluit, Nunavut: an Analysis of the Cascade of Care and Cost-Effectiveness of a Novel Treatment Regimen
    Christopher Pease, MSc in Epidemiology
  • Application of a whole genome approach to the high throughput discovery of novel diagnostic antigens for Brucella abortus
    Teresa Nguyen, MSc in Microbiology and Immunology
  • Deciphering the functional redundancy of USP4 and USP15
    Sarah Zachariah, MSc in Biochemistry

April 2020


  • MiR-1908 Is a Cholesterol Responsive MicroRNA Implicated In Cholesterol Regulation
    Kaitlyn Beehler, MSc in Biochemistry
  • Medical Cannabis for the Treatment of Drug-Resistant Epilepsy in Children: A Health Technology Assessment
    Jesse Elliott, PhD in Epidemiology
  • Identifying Genes Required for Saccharomyces cerevisiae Growth in Mucin
    Kevin Mercurio, MSc in Biochemistry
  • Viral Sensitizers Potentiate the Infection of Cancer Cells Via NF-kB
    Michael Phan, MSc in Microbiology and Immunology
  • Genetic Engineering of Yeast with Novel Properties Using Localized Hypermutation
    Bledar Xhialli, MSc in Biochemistry
  • Major Depression in The Canadian Armed Forces: A Study of Incidence and Mental Health Service Use
    François Thériault, PhD in Epidemiology

March 2020


  • Predictors of Non-Adherence to Positive Airway Pressure Therapy in Children
    Herietta Blinder, MSc in Epidemiology
  • Tailoring Oncolytic Viruses for the Treatment of Pancreatic Cancer
    Marie-Ève Wedge, MSc in Cellular and Molecular Medicine
  • Ubiquitination and proteasomal regulation of Pannexin 1 and Pannexin 3
    Anna Blinder, MSc in Cellular and Molecular Medicine
  • New Advances in Our Understanding of the Control and Functions of Brown Adipose Tissue Thermogenesis
    Rajaa Sebaa, PhD Biochemistry
  • Tailoring Oncolytic Viruses for the Treatment of Pancreatic Cancer
    ​​​​​​Marie-Ève Wedge, MSc in Cellular and Molecular Medicine

February 2020


  • Elucidating the roles of GATA3 and IL-10 in the development and function of Natural Killer cells during murine cytomegalovirus infection
    Alaa Ali, PhD in Microbiology and Immunology
  • Impact of storage and cryoprotectants on the function of cord blood hematopoietic stem cells
    Suria Jahan, PhD in Microbiology and Immunology
  • Economic Evaluation of Rapid HIV testing approaches
    Olanrewaju Ayodeji Medu, PhD in Epidemiology
  • An Evaluation of Cell Transfection Strategies to Package Rna in Small Extracellular Vesicles
    Jenna McCann, MSc in Cellular and Molecular Medicine

January 2020


  • Selective Induction of Apoptosis in HIV-infected Macrophages
    Simon Xin Min Dong, PhD in Microbiology and Immunology
  • The Functional Role of Enhancing the Survival and Activity of Progenitor Cells During Stroke Recovery
    Sébastien Denizé, MSc in Neuroscience
  • Neuronal and Electrophysiological Markers of Glioma
    Cristina Diana Ghinda, PhD in Neuroscience
  • Preliminary Evaluation of Matrix Metalloproteinase-13 Selective Radiotracers for Imaging
    Rami Al Haddad, PhD in Biochemistry
  • The Association Between Environmental Factors and the Risk of Paediatric Inflammatory Bowel Disease
    Michael Elten, MSc in Epidemiology
  • Collagen Hydrogels for Regenerative Medicine
    Justina Pupkaite, PhD in Cellular and Molecular Medicine
  • Necrosome Activation and Degradation in Macrophages
    Norah Alturki, PhD in Microbiology and Immunology
  • Characterizing PD-L1-Targeting Extracellular Vesicles Produced by Oncolytic Vaccinia Virus Infection
    Ashley Chen, MSc in Biochemistry
  • Characterizing Suicidal Ideation in Treatment-Resistant Depression Using Neuroimaging
    Patricia Burhunduli, MSc in Neuroscience
  • Dementia in the Population: Investigation Using Population-level Administrative Health Data in Ontario, Canada
    Stacey Fisher, PhD in Epidemiology
  • Spinal Muscular Atrophy : Evidence of a Multi-system Disease
    Marc-Olivier Deguise, PhD in Cellular and Molecular Medicine

December 2019


  • Mapping the Neural Circuits that Modulates the Molecular Switch Between Alternative Interval Timing Behaviours in Drosophila Melanogaster
    Kyle Wong, MSc in Neuroscience
  • Long-Term Mortality, Healthcare Use, and Costs Associated with Sepsis: A Population-Based Retrospective Cohort Study
    Kelly Farrah, MSc in Epidemiology
  • Assessing Obstetrical and Perinatal Outcomes Associated with Maternal Tdap Immunization
    Romina Fakhraei, MSc in Epidemiology
  • Association Between Maternal Pertussis Vaccination During Pregnancy and Early Childhood Health Outcomes
    Meghan Laverty, MSc in Epidemiology
  • Uncovering the Complexity of a Simple Retrovirus:A Study of Glycosylated Gag and Flow
    Tyler Renner, PhD in Microbiology and Immunology
  • Personal Goals Among Women with Breast Cancer: a Scoping Review and Cohort Study
    Andrea Chow, MSc in Epidemiology
  • Dynamics of Super-Enhancers Throughout Myogenesis
    Basma Abdelkarim, MSc in Cellular and Molecular Medicine
  • Neurosafety and Oncotropism of the Oncolytic Farmington Virus in the Treatment of Glioblastoma Multiforme
    Robyn Skillings, MSc in Microbiology and Immunology
  • Investigating the Potential Role of Serotonin-2B Receptor Antagonism in the Antidepressant Response of Adjunctive Aripirazole
    Rami Hamati, MSc in Neuroscience
  • Catecholaminergic Axonal Remodeling in Motor Cortex of Mice Following Stroke
    Aida Said, MSc in Neuroscience
  • The Role of the Circadian Clock in Hippocampal Aging and as a Therapeutic Target in Alzheimer’s Disease
    Paula Adler, PhD in Biochemistry

November 2019


  • The Role of Neuronal Dystonin in Sensory Neuron Survival
    Anisha Lynch-Godrei
  • The Combined and Differential Effects of Monophasic and Biphasic Repetitive Transcranial Magnetic Stimulation on ERP-indexed Attentional Processing in Treatment-resistant Depression
    Molly Hyde, MSc in Neuroscience
  • Bioengineering Vaccinia Viruses for Increased Oncolytic Potential
    Adrian Pelin, PhD in Biochemistry
  • Characterizing the Role of α-Synuclein in Innate Defenses
    Christopher Rousso, MSc in Neuroscience
  • A Battle Against the Opioid Crisis: Deciphering the Molecular Control of Opioid Receptors in an Effort to Design Safer Analgesics
    Abdulhamid Mohamud, MSc in Biochemistry
  • Developing an Oncolytic Prime-boost Vaccine Targeting the Tumour Associated Antigen Mesothelin for the Treatment of Pancreatic Cancer
    Katherine Baxter, MSc in Cellular and Molecular Medicine

October 2019

  • The Identification of MTF2-specific Synthetic Lethal Interactions in Refractory Acute Myeloid Leukemia Using CRISPR
    Christopher Cafariello, MSc in Cellular and Molecular Medicine
  • Investigation of the Mechanisms of Action of Ketamine on the Glutamate and Monoamine Systems
    Chidiebere Michael Iro, MSc in Neuroscience
  • Modeling and Therapeutic Development for the Tuberous Sclerosis Related Neoplasm Lymphangioleiomyomatosis
    Sean Delaney, PhD in Cellular and Molecular Medicine
  • Gene Expression Analysis of the Perinatal Heart and the Identification of Mir-205 as a Regulator of Cardiomyocyte Maturation
    Jonathan Weldrick, PhD in Cellular and Molecular Medicine

September 2019

  • Examining Lifestyle Behaviours and Weight Status of Primary Schoolchildren: Using Mozambique to Explore the Data Gaps in Low- and Middle-Income Countries
    Taru Manyana, PhD in Epidemiology
  • Mechanistic and Therapeutic Insights of Macrophage MicroRNA in Atherosclerosis
    My-Anh Nguyen, PhD in Biochemistry

August 2019

  • Improving our Ability to Define and Predict Hematoma Expansion in Intracerebral Hemorrhage: A Detailed Analysis of Prospective Intracerebral Hemorrhage Cohorts
    Vignan Yogendrakumar, MSc in Epidemiology
  • Identification and Validation of Small Molecules Inhibiting Human Adenovirus Replication
    Bratati Saha, PhD in Biochemistry
  • Policy and Regulatory Interventions to Reduce Antimicrobial Resistance: Evidence and Analytic Strategies
    Susan Rogers Van Katwyk, PhD in Epidemiology
  • The Impact of Parkinson’s Disease on Mammalian Adult Neurogenesis
    Joseph Bastasic, MSc in Neuroscience
  • Discovery and Application of Neoepitopes in an Oncolytic Rhabdovirus Vaccine Approach to Treat Glioblastoma Multiforme
    Zachary Jilesen, MSc in Microbiology and Immunology
  • Role of BDNF in Cardiac Remodeling and Dysfunction in Rats After Myocardial Infarction
    Heow Won Lee, PhD in Cellular and Molecular Medicine
  • Pointillism in Plant Systems Biology: I. Proteomic Analysis of Plant Exosome-Like Particles Ii. Amyloplast-Binding Puroindoline Fusion Proteins for Recombinant Protein Expression
    Trevor Greenham, PhD in Biochemistry

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