Bernard Thebaud

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Bernard Thebaud
Professor of Pediatrics, University of Ottawa, University of Ottawa Partnership Research Chair in Regenerative Medicine and Senior Scientist, Regenerative Medicine at Ottawa Hospital Research Institute and CHEO Research Institute

Dr. Bernard Thébaud

Biography

Dr. Thébaud is a senior scientist with the Ottawa Hospital Research Institute and a neonatologist with the Children’s Hospital of Eastern Ontario, where he provides care to critically ill newborns. He is also a Professor of Pediatrics at the University of Ottawa.

Dr. Thébaud has participated on numerous peer review committees and scientific advisory boards at the international, national and provincial level, including NIH and CIHR. His research is supported in part by a 7-year CIHR Foundation Scheme award, as well as the NIH and Canadian Stem Cell Network. He has over 100 peer-reviewed publications, and given over 50 lectures at leading international meetings and institutions over the past 5 years. He received the “Best in Current Canadian Child Health Research” Sanofi Pasteur Research Award in 2007, the “Rising Star in Perinatal Research” award from the CIHR Institute for Human Development, Child and Youth Health in 2008, and held a Canada Research Chair from 2006-2012. Dr. Thébaud currently holds the University of Ottawa Partnership Research Chair in Regenerative Medicine since 2012.

Training

Dr. Thébaud obtained his MD at the University Louis Pasteur in Strasbourg, France in 1991 and trained in pediatrics and neonatology at the University Paris V in Paris, France, where he also obtained his MSc and PhD. He then completed a postdoctoral fellowship at the University of Alberta, where he subsequently developed a research program to explore the repair potential of stem cells for neonatal lung diseases. Dr. Thébaud moved to Ottawa in 2012 to accelerate the translation of stem cells from the lab into patients.

Patient Care Philosophy

First, do no harm. When evidence does not exist, common sense and experience should prevail. Even when evidence exists, probe if this specific patient fits the evidence. Less is more.

Research Interests

Dr. Bernard Thébaud is a clinician-scientist focused on the clinical translation of stem cell-based therapies for lung diseases. He has set out an ambitious research program in order to study clinically relevant questions for translation into real-life applications. His group was the first to show that stem cells derived from human perinatal tissue (placenta, umbilical cord/cord blood) prevent/restore experimental neonatal lung damage. He is now extending his observations to other complications of prematurity.

Over the next five years, his goal is to bring safe and effective cell-based therapies for lung diseases into the clinic, and thereby create vast improvements in patient outcomes.

Selected Publications

  • Solomon I, O’Reilly, Ionescu L, Alphonse RS, Rajabali S, Zhong S, Vadivel A, Shelley WC, Yoder MC, Thébaud B. Functional differences between placental micro- and macrovascular endothelial colony-forming cells. Stem Cells Transl Med. 2016 Mar;5(3):291-300.
  • Alphonse RS, Vadivel A, Zhong S, McConaghy S, Ohls R, Yoder MC, Thébaud B. The isolation and culture of endothelial colony-forming cells from human and rat lungs. Nat Protoc. 2015 Nov;10(11):1697-708.
  • Alphonse RS, Vadivel A, Fung M, Shelley WC, Critser PJ, Ionescu L, O’Reilly M, Ohls RK, McConaghy S, Eaton F, Zhong S, Yoder M, Thébaud B. Existence, functional impairment and lung repair potential of endothelial colony forming cells in oxygen-induced arrested alveolar growth. Circulation. 2014 May 27;129(21):2144-57.
  • Pierro M, Ionescu L, Montemurro T, Vadivel A, Weissmann G, Oudit G, Emery D, Bodiga S, Eaton F, Péault B, Mosca F, Lazzari L, Thébaud B. Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia. Thorax. 2013 May;68(5):475-84. doi: 10.1136/thoraxjnl-2012- 202323. Epub 2012 Dec 4.
  • Luong C, Rey-Perra J, Vadivel A, Gilmour G, Sauve Y, Koonen D, Walker D, Todd KG, Gressens P, Kassiri Z, Nadeem K, Morgan B, Eaton F, Dyck JR, Archer SL,  Thébaud B. Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation. 2011 May 17;123(19):2120-31.
  • van Haaften T, Byrne R, Bonnet S, Rochefort GY, Akabutu J, GJ Rey-Parra, Bouchentouf M, Galipeau J, Haromy A, Eaton F, Chen M, Hashimoto K, Abley D, Korbutt G, Archer SL, Thébaud B. Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. Am J Respir Crit Care Med. 2009; 180(11):1131-42.
  • Thébaud B, Ladha F, Michelakis E, Sawika M, Thurston G, Eaton F, Hashimoto K, Harry G, Haromy A, Korbutt G, Archer SL. Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation. 2005 Oct 18;112(16):2477-86.
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