Barbara Vanderhyden


Barbara Vanderhyden
Professor, Cellular and Molecular Medicine and Senior Scientist, Cancer Therapeutics Program

Dr. Barbara Vanderhyden


Barbara Vanderhyden completed her Ph.D. in Reproductive Physiology at the University of Western Ontario in 1988.  She then did postdoctoral studies at The Jackson Laboratory in Maine, where she learned to climb mountains, both literally and scientifically.  In 1991, she joined the Cancer Research Group at the University of Ottawa, which has evolved into the Cancer Therapeutics Program at the Ottawa Hospital Research Institute, where she is a Senior Scientist.  Dr. Vanderhyden is also a Professor at the University of Ottawa and has held the inaugural Corinne Boyer Chair in Ovarian Cancer Research since 2000.  She established and ran the university’s transgenic mouse facility for 14 years.  In her spare time, she established and oversees two science outreach programs, Let’s Talk Science / Parlons sciences, which makes science fun for students in local schools, and Science Travels / La science voyage, which sends teams of grad students to deliver science workshops in remote First Nations and Inuit communities in the far north.

Selected Publications

  • Al-Hujaily EM, Y Tang, D-S Yao, E Carmona, K Garson and BC Vanderhyden (2015). Divergent roles of PAX2 in the etiology and progression of ovarian cancer.  Cancer Prev. Res. 8: 1163-1173.
  • McCloskey CW, Goldberg RL, Carter LE, Gamwell LF, Al-Hujaily EM, Collins O, Macdonald EA, Garson K, Daneshmand M, Carmona E and Vanderhyden BC (2014). A new spontaneously transformed syngeneic model of high-grade serous ovarian cancer with a tumor-initiating cell population. Front Oncol. 4: 53.
  • Laviolette LA, Hodgkinson KM, Minhas N, Perez-Iratxeta C, Vanderhyden BC (2014). 17β-estradiol upregulates GREB1 and accelerates ovarian tumour progression in vivo.  Int. J. Cancer. Jan 27. doi: 10.1002/ijc.28741. 
  • Gamwell LF, M Merziotis, K Gambaro, SL Arcand, V Snoulten, C Davis, JA Squire, DL Huntsman, PN Tonin and BC Vanderhyden (2013). Characterization of a small cell ovarian cancer cell line:  Genomic anomalies and responsiveness to therapeutics. Orphanet Journal of Rare Diseases 8: 33. 
  • Gamwell LF, O Collins and BC Vanderhyden (2012). The mouse ovarian surface epithelium contains a population of LY6A (SCA-1) expressing progenitor cells that are regulated by ovulation-associated factors.   Biol. Reprod. 87: 80.

Fields of Interest

  • Mouse Models of Ovarian Cancer
  • Progenitor cells in the ovarian surface epithelium
  • Chromatin remodelling proteins involved in cellular differentiation
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