The Ottawa Hospital Research Institute (OHRI) is one of the lead sites in Canada for the study of human reproductive health. Its research addresses important women's and infant health issues and cuts across institute programs including Chronic Disease, Cancer Therapeutics Program and Clinical Epidemiology. It is one of the Institute's best examples of "bench to bedside to community and back" research efforts.
Through their basic and translational research sited at the OHRI, scientists within the Department of Obstetrics and Gynecology, University of Ottawa cover a broad range of reproductive issues. Supported by the Canadian Institutes of Health Research, their research focuses on cell fate regulation in women’s reproductive health (Tsang, Benjamin), mammalian oocyte growth and maturation and early embryo development (Baltz, Jay), the molecular mechanisms of sperm-egg interaction (Tanphaichitr, Nongnuj), development of non-hormonal contraceptives and biomarkers of gamete fertilizing ability (Tanphaichitr, Nongnuj), progenitor cells in the ovarian surface epithelium (Vanderhyden, Barbara) and chromatin remodeling proteins in cellular differentiation (Vanderhyden, Barbara), transmission mechanisms of HIV-1 and other microbes through vaginal and cervical epithelial cells (Tanphaichitr, Nongnuj), mechanisms of polar body formation during animal oocyte maturation, and putrescine supplementation to improve advanced maternal-age infertility( Liu, Johné), polycystic ovarian syndrome (Tsang, Benjamin), animal model for ovarian cancer (Vanderhyden, Barbara), molecular basis of chemoresistance in ovarian cancers (Tsang, Benjamin).
In addition, through the established graduate programs of the Department of Cellular and Molecular Medicine and the Department of Biochemistry, Microbiology and Immunology, graduate students and postdoctoral fellows are enjoying cutting-edge research training in reproductive health under the mentorship of scientists in the Department of Obstetrics and Gynecology.