The Ottawa Institute of Systems Biology is located at the Faculty of Medicine of the University of Ottawa. The aim of the institute is to develop and apply systems biology to biological studies relevant to human diseases.
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Addicks et al. identify a role for protein acetylation in the regulation of muscle integrity by linking GCN5 acetyltransferase activity to the expression of dystrophin and other genes important for muscle structure. They find that this occurs through GCN5-directed acetylation of the transcriptional repressor YY1.
