Research Associate - Bioinformatics
Contact/Scientist: Dr. Marjorie Brand
The Ottawa Hospital Research Institute (OHRI) is an Affiliated Research Institute of the University of Ottawa and the research arm of The Ottawa Hospital. The OHRI has grown rapidly to become one of the largest and most important hospital-based research institutes in Canada.
The OHRI has an opening for a full-time Research Associate in the lab of Dr. Marjorie Brand located at the General Campus of The Ottawa Hospital. http://www.ohri.ca/profile/Brand_Lab/brand-lab
Project description and responsibilities:
Our lab is continuously generating large datasets from high throughput genomic experiments (RNA sequencing, Chromatin immunoprecipitation sequencing), proteomic experiments (mass spectrometry), three-dimensional nuclear organization experiments (HiC, Hi ChIP, CaptureC) as well as single cell RNA sequencing and single cell mass cytometry (CyTOF). We are looking for a candidate with a background in bioinformatics, computer science, biology, mathematics and/or physics, as well as some previous experience and interest in biological questions (particularly genomics) regarding the regulation of gene expression. The lab uses human and mouse blood development and leukemia as model systems.
The successful candidate will work with postdoctoral fellows and graduate students in the planning and analyzes of large datasets to address specific biological questions. The successful candidate will be responsible for maintaining and upgrading analyses pipelines that have been previously established according to the lab’s needs. There will also be a number of exciting opportunities to establish new pipelines and analyses methods to address specific biological questions. The postholder will also collaborate in the preparation of research publications and participate in relevant collaborative projects with colleagues in partner institutions. Furthermore, the postholder will provide guidance/supervision and training to junior members of the research group. The postholder will maintain excellent data records.
We are looking for an enthusiastic and pro-active individual, with superior organization and communication skills who enjoys working with biologists, students and postdoctoral fellows. We offer exciting projects and opportunities for further training and education.
Benefits and Opportunities:
This is a full-time, 2-year position with the possibility of renewal. This position offers an excellent benefits package and HOOPP pension.
Postdoctoral fellowship position in Bioinformatics in the Stintzi and Lavallée-Adam Laboratories
Start Date: As soon as possible
Salary: $50,000 CAD/year with benefits
Project description: The focus of the project is on the large-scale analysis of multi-omics datasets from human gut microbiome in the context of pediatric inflammatory bowel diseases. The goal of the project is to integrate the results of metagenomics, metatranscriptomics and metaproteomics datasets in a machine learning framework to identify predictive signatures of treatment responses in inflammatory bowel disease patients and classify them accordingly.
This research will take place at the Faculty of Medicine of the University of Ottawa. Ottawa is considered to be one of the best livable cities on the globe.
The ideal candidate should:
- Have a Ph.D. in Bioinformatics, Computational Biology, Machine Learning, Biostatistics, Genomics, or a related field
- Have experience with omics data analysis from next-generation sequencing technologies
- Have knowledge and experience with large-scale biological data analysis
- Have experience in analyzing clinical datasets
- Have experience in the computational analysis of large biological datasets such as ENCODE and TCGA.
- Be experienced with machine learning techniques applied to large biological datasets
- Have proficiency in a programming language such as Java, C, C++, Python, R or Matlab.
- Be comfortable in a Linux environment.
- Be a team player
- Have the ability to work independently
- Have strong written and verbal communication skills and a good ability to communicate with colleagues in biological sciences
- Have a strong publication record.
Additional assets considered for this position:
- Have experience in proteomics data analysis
- Have a working knowledge of annotation databases such as Gene Ontology, GeneCards, Ensembl, and Reactome
- Have experience working in a collaborative and multidisciplinary team environment
To apply for this position:
Please submit a complete CV, a cover letter and the names and contact information of three references to Dr. Mathieu Lavallée-Adam at this address: email@example.com
RESEARCH ASSOCIATE – BAETZ LAB
The Baetz lab is looking for a scientifically strong, self-motivated and enthusiastic Research Associate to work in the area of stress biology, cellular metabolism and cancer research. You are a highly innovative scientist with a proven track-record in biochemistry and molecular biology, ideally with a background in yeast genetics and /or functional genomics. The successful candidate will be required to plan experiments, analyze and interpret data, and effectively communicate results. The candidate should be able to demonstrate a record of a strong work ethic, successful supervision of trainees, while being in a cooperative and fast-paced work environment.
PhD in Molecular Biology or Biochemistry (or closely related field) and Postdoctoral or work experience in an intensive research environment. Preference will be given to candidates with experience in Saccharomyces cerevisiae research and/or cell cycle or metabolism research.
- Expertise in a variety of basic and specialized laboratory techniques and procedures, including advanced microscopy, qPCR, protein purification, CRISPR and cloning. Preference will be given to candidates with yeast genetics or functional genomics expertise.
- Experience microbiological techniques
- Skills and/or experience supervising and training students
- Ability to prioritize tasks, meet deadlines and manage multiple projects simultaneously
- Ability to learn and integrate new techniques & methodologies
- Strong analytical, problem solving and critical thinking skills
- Outstanding interpersonal and organizational skills.
- Strong communications skills required, including demonstrated ability to prepare publications independently.
- Statistical experience is an asset, but not essential
Additionally you will:
- In collaboration with Dr Baetz, you will design, develop, and execute laboratory experiments leading your own research project (50%)
- Supervise and train new graduate and undergraduate students (20%)
- General Laboratory management: ordering, maintaining financial records, supervises all aspects of the laboratory including implementation and adherence to all applicable safety regulations and maintaining laboratory equipment (20%)
- Preparation of figures using computer software and writing/editing documents (10%)
If this job is right for you and you are ready for the next stage in your career -please send your cover letter, CV and names of three references to firstname.lastname@example.org
The Baetz lab is seeking a postdoctoral fellow and PhD student
The Baetz lab is looking for highly motivated and creative researchers to join our team. The focus of the work will be understanding how cellular metabolism is remodelled through lysine acetylation upon various stresses. In this study yeast functional genomics along with high throughput microscopy will be exploited to identify novel pathways regulated by the highly conserved lysine acetyltransferase NuA4. Once characterized in yeast, you will seek to determine if the same events are regulated by Tip60 in mammalian cells. This is a great opportunity to learn yeast systems biology and "connect the unconnected".
If you are interested in this opportunity, send your CV, along with contact information for three references to email@example.com. Only qualified candidates will be contacted. We are a member of the Ottawa Institute of Systems Biology at the University of Ottawa, in Ottawa, Canada.
OISB Principal Investigators are always looking for undergraduates, graduate students and post-doctoral fellows who want to join our competitive multi-disciplinary research programs. Please contact our Principal Investigators directly.