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Category: Laboratory Research

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Research Associate - Bioinformatics

Contact/Scientist: Dr. Jeffrey Dilworth
Program: Regenerative Medicine

The Ottawa Hospital Research Institute (OHRI) is an Affiliated Research Institute of the University of Ottawa and the research arm of The Ottawa Hospital. The OHRI has grown rapidly to become one of the largest and most important hospital-based research institutes in Canada.

The OHRI has an opening for a full-time Research Associate to support the labs of Dr. Jeff Dilworth and Dr. Lynn Megeney located at the General Campus of The Ottawa Hospital.

http://www.ohri.ca/profile/F_Jeffrey_Dilworth

http://www.ohri.ca/profile/lmegeney

Project description and responsibilities:

Our labs are continuously generating large datasets from high throughput genomic experiments (RNA sequencing, Chromatin immunoprecipitation sequencing), proteomic experiments (mass spectrometry), three-dimensional nuclear organization experiments (HiC, Hi ChIP, CaptureC) as well as single cell RNA sequencing and single cell mass cytometry (CyTOF). We are looking for a candidate with a background in bioinformatics, computer science, biology, mathematics and/or physics, as well as some previous experience and interest in biological questions (particularly genomics) regarding the regulation of gene expression. The labs use human and mouse muscle regeneration and heart muscle cells as model systems.

The successful candidate will work with postdoctoral fellows and graduate students in the planning and analyzes of large datasets to address specific biological questions. The successful candidate will be responsible for maintaining and upgrading analyses pipelines that have been previously established according to the lab’s needs. There will also be a number of exciting opportunities to establish new pipelines and analyses methods to address specific biological questions. The postholder will also collaborate in the preparation of research publications and participate in relevant collaborative projects with colleagues in partner institutions. Furthermore, the postholder will provide guidance/supervision and training to junior members of the research group. The postholder will maintain excellent data records.

 

We are looking for an enthusiastic and pro-active individual, with superior organization and communication skills who enjoys working with biologists, students and postdoctoral fellows. We offer exciting projects and opportunities for further training and education.

Basic Requirements:

  • Master or PhD degree in bioinformatics, computer science, molecular biology, biochemistry, mathematics and/or physics
  • Previous experience in biological data analysis
  • Previous experience in the analysis of genomics data would be an advantage

Benefits and Opportunities:

This is a full-time, 2-year position with the possibility of renewal. This position offers an excellent benefits package and HOOPP pension.

Salary Range:
Min: $27.413/hr Max: $37.187/hr

Please send a single pdf file of your cover letter, complete CV with description of research experience and contact information for 3 references to Sandy Martino at smartino@ohri.ca
 

 

Postdoctoral fellowship position in Bioinformatics in the Stintzi and Lavallée-Adam Laboratories

Start Date: As soon as possible

Salary: $50,000 CAD/year with benefits

Project description: The focus of the project is on the large-scale analysis of multi-omics datasets from human gut microbiome in the context of pediatric inflammatory bowel diseases. The goal of the project is to integrate the results of metagenomics, metatranscriptomics and metaproteomics datasets in a machine learning framework to identify predictive signatures of treatment responses in inflammatory bowel disease patients and classify them accordingly.

This research will take place at the Faculty of Medicine of the University of Ottawa. Ottawa is considered to be one of the best livable cities on the globe.

The ideal candidate should:

  • Have a Ph.D. in Bioinformatics, Computational Biology, Machine Learning, Biostatistics, Genomics, or a related field
  • Have experience with omics data analysis from next-generation sequencing technologies
  • Have knowledge and experience with large-scale biological data analysis
  • Have experience in analyzing clinical datasets
  • Have experience in the computational analysis of large biological datasets such as ENCODE and TCGA.
  • Be experienced with machine learning techniques applied to large biological datasets
  • Have proficiency in a programming language such as Java, C, C++, Python, R or Matlab.
  • Be comfortable in a Linux environment.
  • Be a team player
  • Have the ability to work independently
  • Have strong written and verbal communication skills and a good ability to communicate with colleagues in biological sciences
  • Have a strong publication record.

Additional assets considered for this position:

  • Have experience in proteomics data analysis
  • Have a working knowledge of annotation databases such as Gene Ontology, GeneCards, Ensembl, and Reactome
  • Have experience working in a collaborative and multidisciplinary team environment

 

To apply for this position:

 

Please submit a complete CV, a cover letter and the names and contact information of three references to Dr. Mathieu Lavallée-Adam at this address: mathieu.lavallee@uottawa.ca

 


 

Postdoctoral Fellow at the Institute for Systems Biology in Seattle

Department:

Ranish Lab

Location:

Seattle, WA

 

 

The Ranish Group at the Institute for Systems Biology is seeking a highly motivated scientist to conduct research investigating how hematopoietic stem cells differentiate into mature red blood cells. To accomplish this goal, the lab is developing mass spectrometry-based technology to quantify the transcription factor proteome as cells differentiate. The data will be used to model the transcriptional regulatory networks underlying this process.  The models will guide future experiments to understand how specific transcription factors drive cell fate decisions. The successful applicant will be expected to design, execute, analyze, and troubleshoot experiments.

Lab website:

https://isbscience.org/people/labs/ranish-lab/

Key responsibilities include 

  • Development and application of mass spectrometry-based proteomics technologies
  • Recombinant protein expression and purification
  • Discuss and present research at internal meetings
  • Manuscript preparation

Qualifications:

  • PhD in analytical chemistry or biomedical sciences (i.e., molecular/cellular biology or biochemistry)
  • Strong interest in mass spectrometry-based proteomics and gene regulation
  • Ability to organize and prioritize work, work efficiently and independently
  • Strong verbal and written communication skills


  •  
InformationThe Trinkle lab (http://trinklelab.com) is currently recruiting a graduate student and lab technician.  Interested candidates should send their CV to ltrinkle@uottawa.ca

 

The D’Amours laboratory is currently recruiting graduate students and post-doctoral fellows. Please send your CV to: damien.damours@uottawa.ca
Information.

 

 

Note
InformationOISB Principal Investigators are always looking for undergraduates, graduate students and post-doctoral fellows who want to join our competitive multi-disciplinary research programs. Please contact our Principal Investigators directly.

 

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