Check out the OISB2019 Scientific Conference

Posted on Thursday, May 2, 2019


L’institut de la Biologie des Systèmes d’Ottawa                                            Ottawa Institute of Systems Biology


2019 Ottawa Institute for Systems Biology Symposium

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May 6 – 7, 2019





Address:       1950 Montreal Rd,

 Cornwall, ON

 K6H 6L2

Need a ride?  Have space in your vehicle?  Register at:

Talks begin at 10:00am on May 6.

Accommodations Check-in:      2:00pm

Accommodations Checkout:    12:00pm

There is luggage storage in the lobby area.

  • All talks will take place in the Plenary D214.
  • Poster session will take place in the De Havilland Room

Posters should be 36” x 48”

  • All meals will take place in the Propeller Restaurant

Schedule for May 6, 2019




Opening Address by Kristin Baetz


Metabolism: Getting going and keepin’ it running    Chair: Mireille Khacho


Elizabeth Walden

Baetz Lab

What is the skinny on the fat KAT? - Defining the role of the yeast lysine acetyltransferase NuA4, and its human homolog Tip60, in metabolism

10:30- 10:45

Jens Halling

Visiting scientist

Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in aged mice

10:50 - 11:05

Rajaa Sebaa

Harper Lab

SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1

11:10 - 11:25

Nicole Baker

Khacho Lab

The role of mitochondrial Opa1 in satellite stem cell function and skeletal muscle regeneration



Keynote Lecture: Dr. Oliver Fiehn UC Davis


12:30 – 13:30

Lunch – Roundtable discussion


Proteins and PTMs – Charged up and out of site!   Chair: Mike Downey

13:35 – 13:50

Paula Adler

Figeys Lab

Therapeutic targeting of casein kinase 1δ/ε in an Alzheimer's disease mouse model

13:55 – 14:10

Amanda Bentley-DeSousa

Downey Lab

Investigating the regulation of polyphosphate metabolism by the conserved AP3 complex

14:15 – 14:30

Natasha Trzaskalski

Mulvihill Lab

Identification of Cardioactive Dipeptidyl Peptidase 4 Substrates

14:35 – 14:50

Laurence Langlois-LeMay

D’Amours Lab

Investigating the role of the polo-like kinase Cdc5 in the adaptation response to DNA damage





Imaging metabolic pathways  Chair: Laura Trinkle-Mulcahy

15:10 – 15:25

Terry Suk

Rousseaux Lab

Systems based approach to uncover regulatory mechanisms of TDP-43 mislocalization in ALS

15:30 – 15:45

Danny Salem

Kaern Lab

Using the Tandem Fluorescent Timer as a Reporter of Dynamic Gene Regulation


15:50– 16:05

Alexia Kirby

Shuhendler Lab

Molecular imaging of aldehydes as bio-markers of injury and disease

16:10 –16:25

Adam Pietrobon

Stanford Lab

High throughput small molecule screening with 3D lung-mimetic hydrogels in a rare lung disease Lymphangioleiomyomatosis



Posters + Cocktail Reception





SOCIAL  - Jet Set Pub


Schedule for May 7, 2019

7:00 – 9:00



 Bioinformatics - Making sense of “META” Data  Chair: Steffany Bennett

9:00 – 9:15

Reyhaneh Hosseini

Bickel Lab

Comparing the methods of combination for the local false discovery rate estimates of gene expression data

9:20 – 9:35

Justin Chitpin

Bennett/Perkins Labs

Bioinformatics for quantitative lipidomics discovery: Identifying lipids from precursor ion scan and multiple reaction monitoring mass spectrometry using structure-retention time relationships

9:40 – 9:55

Janice Ou

Jeff Xia Lab (McGill)

mGWAS-Explorer: a comprehensive knowledgebase and analytical platform to study genetically influenced metabotypes

10:00 – 10:15

Xuhua Xia

Xuhua Xia Lab

RNA-Seq approach for accurate characterization of splicing efficiency of yeast introns


10:20 – 10:40

Coffee break


The Future Is Here! New technologies for understanding metabolism   Chair: Mary-Ellen Harper

10:45 – 11:00

Mary-Ellen Harper

Harper Lab

Racehorse vs Workhorse, and other considerations in cellular and mitochondrial respirometry

11:05 – 11:20

Meir Menzies

Menzies Lab

The better mouse model: using genetic diversity to investigate complex diseases


11:25 – 11:40

David Patten

Metabolomics Core - St Pierre/Bennett

The New uOttawa Metabolomics Core Facility: Integrating Targeted, Untargeted and Stable Isotope Tracing Analyses to Your Projects

11:45 – 12:00

Hongbin Xu

Metabolomics Core - St Pierre/Bennett

Mass spectrometry-based lipidomics for interrogating metabolism


12:30 – 13:30



Genome biology: Transcription and repair   Chair: Damien D’Amours


13:30 – 13:45

Yidai Yang

Couture Lab

A monovalent zinc binding site stabilizes the integration of Cfp1 into SET1 complexes

13:50 – 14:05

Carmen Palii

Brand Lab

TAL1 subverts the function of the T-cell regulator BCL11B to induce and maintain T-ALL

14:10 – 14:25

Jamie Whitcomb

Nemer Lab

Identification of GATA4 Pathways for Transcriptional Regulation of Angiogenesis


Daniel Robinson

Dilworth Lab

Promoter-proximal stalling of RNA-Polymerase II is required for repopulation of the satellite cell niche after muscle injury


14:50 – 15:00

Closing remarks and poster awards


15:00 – 15:40

PI meeting



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