Polyphosphate are chains of inorganic phosphates found in diverse cells from bacteria to humans. Though polyphosphates are considered and "ancient" molecule, little is known about the global impact of polyphosphorylation on protein function. To answer this question, the Downey lab performed a screen in yeast to identify polyphosphorylated proteins in yeast and identified 15 new yeast targets. Importantly they characterize a role for polyphosphorylation in the regulation of translation in both yeast and human cells.
Read the full paper at: http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30314-0