Cover Shot - the Downey Lab identifies novel targets of lysine polyphosphorylation and makes the cover of Cell Reports

Posted on Monday, April 9, 2018

graphical abstract

Graphical Abstract 

Polyphosphate are chains of inorganic phosphates found in diverse cells from bacteria to humans.  Though polyphosphates are considered  and "ancient" molecule, little is known about the global impact of polyphosphorylation on protein function.  To answer this question, the Downey lab performed a screen in yeast to identify polyphosphorylated proteins in yeast and identified 15 new yeast targets.  Importantly they characterize a role for polyphosphorylation in the regulation of translation in both yeast and human cells.  

Read the full paper at:

Cover of Cell Reports

Photo credit : Cell Reports


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