D'Amours lab show that microtubules are both brawn and brain.

Posted on Monday, March 18, 2019

Graphical abstract

Photo credit : https://www.sciencedirect.com/science/article/pii/S221112471930230X

Microtubules are both Brawn and Brain!

DNA replication stress is detected in S phase by a dedicated checkpoint machinery that ensures cells do not enter mitosis with damaged chromosomes. The D'Amours lab found that microtubules limit the effects of replication stress to S phase by modulating the levels of tension at sister kinetochores of replciated chromatids.  

Read the full article at:  https://www.sciencedirect.com/science/article/pii/S221112471930230X

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