MATRIX-OISB Special Seminar

Posted on Wednesday, May 12, 2021

seminar poster

Metabolomics: beyond biomarkers and towards deciphering unknown biology

J. Rafael Montenegro-Burke

Donnelly Centre for Cellular and Biomolecular Research University of Toronto

Mass spectrometry-based untargeted metabolomics is an emerging field focused on the profiling of small molecules, collectively known as the “metabolome”, in biological fluids and tissues. Over the past 15 years, innovative analytical and bioinformatics strategies have been developed, making it possible to identify metabolic fingerprints as biomarkers and prioritize dysregulated metabolites for activity screening and determine their biological function in specific phenotypes. However, many metabolites are yet to be identified, let alone reported, characterized or incorporated into libraries. These metabolites, commonly referred to as the “dark metabolome” are found dysregulated in different phenotypes and their identification represents a considerable challenge for the basic understanding of many biological processes. This seminar will focus on current progress in biological applications and chemical biology developments for metabolite identification that advance our understanding of biological processes

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