This facility contains a crystallization robot for the high throughput crystallization of biological macromolecules, including DNA, RNA and proteins. In addition, the core has a Rigaku MicroMAX 007-HF for structure resolution equipped with a RAXIS-4 Detector.
Our proteomic core facility has a complete series of state-of-the art mass spectrometers. We offer the research community a complete array of proteomic services from protein and PTM identification to super silac and single cell proteomics.
We provide advice on bioinformatics research design, conduct bioinformatics analysis, provide data warehousing services and provide support for grant proposals that involve bioinformatics (including conducting pilot studies, support/collaboration letters, methodological text and more).
LPR is a lipidomics and lipid-bioinformatics research platform that provides a complete range of services, from extraction, MS analysis, bioinformatics and visualization/network tools. This platform is unique in its combined application of LC-ESI-MS, bioinformatics, 3D visualization and hybrid representation softwares adapted for lipid representation, and super-resolution STED CW evaluation of membrane microdomains through our sister STEDCore suite to neurolipidomics.
STEDCore is the first super-resolution Stimulated Emission Depletion Continuous Wave (STED CW) research platform in Canada. The platform, both confocal and super-resolution systems, is operated by Mr. Mark Akins, who works with Dr. Steffany Bennett to provide researchers with imaging expertise, calibrate and maintain all of STEDCore's equipment, develop new super-resolution analysis protocols and, if requested, perform critical experiments for users.
This facility contains an Agilent 2 microns-resolution microarray scanner with hybridization oven and data analysis workstation; a Covaris S2 sonicator; a Stratagene Mx3000 real-time PCR cycler; and will soon include two high-throughput sequencers, the Personal Genome Machine and the Ion Proton, as well as two Ion One-Touch systems for sample preparation.
This facility contains state-of-the-art infrastructure to study protein structures, including AKTA purification systems combined with size-exclusion columns, a calorimeter for the measurement of protein-ligand thermodynamics and spectrophotomers for the study of protein secondary structures in solution. This facility also includes a crystallization robot to carry out crystallization trials with high throughput capabilities.
This facility contains a Singer ROTOR HAD, a compact benchtop robot for easy, ultra-fast manipulation of high density arrays of yeast. It also contains imaging equipment and a spectrometer for automated growth curve analysis, to allow for functional and chemical genomic yeast screening of mutant collections.