This facility contains a crystallization robot for the high throughput crystallization of biological macromolecules, including DNA, RNA and proteins. In addition, the core has a Rigaku MicroMAX 007-HF for structure resolution equipped with a RAXIS-4 Detector.
Our proteomic core facility has a complete series of state-of-the art mass spectrometers. We offer the research community a complete array of proteomic services from protein and PTM identification to super silac and single cell proteomics.
We provide advice on bioinformatics research design, conduct bioinformatics analysis, provide data warehousing services and provide support for grant proposals that involve bioinformatics (including conducting pilot studies, support/collaboration letters, methodological text and more).
LPR is a lipidomics and lipid-bioinformatics research platform that provides a complete range of services, from extraction, MS analysis, bioinformatics and visualization/network tools. This platform is unique in its combined application of LC-ESI-MS, bioinformatics, 3D visualization and hybrid representation softwares adapted for lipid representation, and super-resolution STED CW evaluation of membrane microdomains through our sister STEDCore suite to neurolipidomics.
STEDCore is the first super-resolution Stimulated Emission Depletion Continuous Wave (STED CW) research platform in Canada. The platform, both confocal and super-resolution systems, is overseen by Dr. Steffany Bennett and provides researchers with imaging expertise, calibrates and maintains all of STEDCore's equipment, development of new super-resolution analysis protocols and, if requested, perform critical experiments for users. Its now part of CBIA core.
Metabolomics Core Facility
Our Metabolomics Core Facility is part of MIRGOV, the Metabolomics Innovation Resource of the Goodman Cancer Research Centre (GCRC), the University of Ottawa and the Van Andel Research Institute (VARI). We house state-of-the-art mass spectrometers for targeted quantification of small molecules, untargeted metabolomics and stable isotope tracing analyses.
This facility contains state-of-the-art infrastructure to study protein structures, including AKTA purification systems combined with size-exclusion columns, a calorimeter for the measurement of protein-ligand thermodynamics and spectrophotomers for the study of protein secondary structures in solution. This facility also includes a crystallization robot to carry out crystallization trials with high throughput capabilities.
This facility contains a Singer ROTOR HAD, a compact benchtop robot for easy, ultra-fast manipulation of high density arrays of yeast. It also contains imaging equipment and a spectrometer for automated growth curve analysis, to allow for functional and chemical genomic yeast screening of mutant collections.
India Taylor Lipidomics Research Platform
The India Taylor Lipidomics Research Platform was established in 2015 in memory of Ms India Taylor’s fight against spinal muscular atrophy with progressive myoclonic epilepsy, a rare lipid neurodegenerative disorder. Developed with the generous support of private donations to the India Taylor Donation fund, the uOttawa Brain and Mind Institute, Partners Investing in Parkinson’s Research, and Canadian Foundation Innovation (CFI) grants (CFI#16065 and CFI#23890), the research platform is open for both collaborative investigations at cost and fee for service. The platform is directed by Dr Steffany Bennett and managed by Mr Graeme Taylor.