Selected Publications

Mads Kaern

Bouchard-Cannon P, Mendoza-Viveros L, Yuen A, Kærn M, Cheng HY. The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit. Cell Rep. 2013 Nov 27;5(4):961-73. doi:10.1016/j.celrep.2013.10.037. Epub 2013 Nov 21.

Phenix H, Perkins T, Kærn M. Identifiability and inference of pathway motifs by epistasis analysis. Chaos. 2013 Jun;23(2):025103. doi: 10.1063/1.4807483.

Le Bœuf F, Batenchuk C, Vähä-Koskela M, Breton S, Roy D, Lemay C, Cox J, Abdelbary H, Falls T, Waghray G, Atkins H, Stojdl D, Diallo JS, Kærn M, Bell JC. Model-based rational design of an oncolytic virus with improved therapeutic potential. Nat Commun. 2013;4:1974. doi: 10.1038/ncomms2974.

Charlebois DA, Abdennur N, Kaern M. Gene expression noise facilitates adaptation and drug resistance independently of mutation. Phys Rev Lett. 2011 Nov 18;107(21):218101. Epub 2011 Nov 14.

Phenix H, Morin K, Batenchuk C, Parker J, Abedi V, Yang L, Tepliakova L, Perkins TJ, Kærn M. Quantitative epistasis analysis and pathway inference from genetic interaction data. PLoS Comput Biol. 2011 May;7(5):e1002048. doi:10.1371/journal.pcbi.1002048. Epub 2011 May 12.

Batenchuk C, St-Pierre S, Tepliakova L, Adiga S, Szuto A, Kabbani N, Bell JC, Baetz K, Kærn M. Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size. Biophys J. 2011 May 18;100(10):L56-8. doi: 10.1016/j.bpj.2011.04.021.

Batenchuk C, Tepliakova L, Kaern M. Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis. BMC Genomics. 2010 Sep 10;11:493. doi: 10.1186/1471-2164-11-493.

Zhuravel D, Fraser D, St-Pierre S, Tepliakova L, Pang WL, Hasty J, Kærn M. Phenotypic impact of regulatory noise in cellular stress-response pathways. Syst Synth Biol. 2010 Jun;4(2):105-16. doi: 10.1007/s11693-010-9055-2. Epub 2010 Apr 22.

Song C, Phenix H, Abedi V, Scott M, Ingalls BP, Kaern M, Perkins TJ. Estimating the stochastic bifurcation structure of cellular networks. PLoS Comput Biol. 2010 Mar 5;6(3):e1000699. doi: 10.1371/journal.pcbi.1000699. Erratum in: PLoS Comput Biol. 2010;6(3). doi:10.1371/annotation/9a35fa58-f81c-41b4-9fa9-c1aeedbf0fff.

Fraser D, Kaern M. A chance at survival: gene expression noise and phenotypic diversification strategies. Mol Microbiol. 2009 Mar;71(6):1333-40. doi:10.1111/j.1365-2958.2009.06605.x. Epub 2009 Feb 10. Review.

Kaern M, Elston TC, Blake WJ, Collins JJ. Stochasticity in gene expression: from theories to phenotypes. Nat Rev Genet. 2005 Jun;6(6):451-64. Review.

Kobayashi H, Kaern M, Araki M, Chung K, Gardner TS, Cantor CR, Collins JJ. Programmable cells: interfacing natural and engineered gene networks. Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8414-9. Epub 2004 May 24.

Blake WJ, Kaern M, Cantor CR, Collins JJ. Noise in eukaryotic gene expression. Nature. 2003 Apr 10;422(6932):633-7.

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