Dr. Adolfo J. De Bold

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Dr. Adolfo J. De Bold
Emeritus Professor

telephone: 613-761-4265
Work E-mail: adebold@ottawaheart.ca

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Biography

Dr. A.J. de Bold is Professor of Pathology and Physiology and Director of the Cardiovascular Endocrinology Laboratory at the University of Ottawa Heart Institute. This laboratory is located in modern facilities within the Research Centre of the Heart Institute, a 100,000 sq ft facilities complete with conference and animal facilities.

Dr. de Bold's research developed from his discovery of the endocrine function of the heart and the cardiac hormone ANF. The laboratory provides opportunities to work in daily contact with three senior scientists, graduate and post-doctoral students as well as with other students from the various research groups. Laboratory journal clubs are held weekly and scientific as well as clinical conferences are held several times a week through the different activities of the Heart Institute. Our general approach to scientific problems aims at maintaining an integrated view of cardiovascular physiology and pathophysiology even in those areas where we investigate at the molecular level.

Current fields of interest include: 1. Transcriptional and posttranscriptional control of natriuretic peptide production (ANF, BNP) by the endocrine heart, protein trafficking and sorting of cardiac polypeptide hormones. 2. Endocrinology of congestive heart failure with special reference to cytokines. 3. Aldosterone production by the heart and, 4. Development of monoclonal antibodies and other activities related to the production of tests for diagnosis of cardiac disease.

Technically, the Laboratory is proficient in a broad spectrum of many modern and classical techniques including light and electron microscopy, immunohistochemistry, various biochemical and molecular biology techniques and both in vivo and in vitro preparations as well as cell culture systems. Our students receive a well rounded technical training, often beyond the requirements of their specific projects.

Current research is funded by three grants from CIHR and one grant from the OHSF.

Recent Publications

  • PLC signaling tonically represses basal atrial natriuretic factor (ANF) secretion from the atria of the heart. Chang, A.I.  and deBold, A.J. Submitted for publication, 2009.
  • The Cardiac Hormones ANF and BNP Modulate Proliferation in the Unidirectional Mixed Lymphocyte Reaction. Kuroski deBold, M.L., Etchepare, A.,  Martinuk, A. and deBold, A.J. J. Heart Lung. Transplant.  Accepted for publication, 2009.
  • Invited Editorial: Cardiac natriuretic peptides: gaining further insights into structure-function relationships. deBold, A.J.J. Am. Coll. Cardiol., In press, 2009. 
  • Transcriptional Analysis of the Heart with Special Reference to its Endocrine Function. McGrath, M.F., Kuroski deBold, M.L. and deBold, A.J. BMC Genomics 10:254, 2009
  • Role of potassium channels in stretch-promoted atrial natriuretic factor (ANF) secretion. Ogawa, T., Forero, M., Burgon, P.G., Kuroski deBold, M.L., Georgalis,T. and deBold, A.J. J.Am.Soc.Hyperten. 3: 9-18,  2009
  • Cardiac Natriuretic Peptides Gene Expression and Secretion in Inflammation. deBold, A.J. Invest. Med.  2009 57: 29-32, 2009 
  • Angiotensin II Receptor Antagonism Reverts Cardiac BNP Upregulation and Secretion Observed in Myocarditis. Ogawa, T, Veinot, J. P., Georgalis, T. and deBold, A. J. Am.J.Physiol. 294: H5296, 2008
  • Relationship between Natriuretic Peptides and Inflammation. Proteomic Evidence Obtained during Acute Cardiac Allograft Rejection in Humans. Meirovich, Y. F.,  Veinot, J. P., Kuroski deBold, M. L.,  Haddad, H., Davies, R.A., Masters, R. G., Hendry, P. J. and deBold, A.J. J.Heart Lung Transplant. 27:31-7. 2008
  • Determinants of Brain Natriuretic Peptide (BNP) Gene Expression and Secretion in Acute Cardiac Allograft Rejection. deBold, A.J.  Current Opinions in Cardiology 22: 146-150, 2007
  • Gene Expression, Processing and Secretion of Natriuretic Peptides.  Physiological and Diagnostic Implications. Ramos, H. and deBold, A.J. Clinics of North America, Heart Failure Clinics 2 (3): 255, 2006

Fields of Interest

  • Synthesis & Mechanism of action of ANF and BNP and their relation to hypertension and congestive heart failure
  • Light and electron microscopy
  • Dosage of polypeptide hormones
  • Molecular Biology
  • in vitro models of disease
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